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Literature summary for 7.6.2.3 extracted from

  • Hong, Y.; Lai, Y.; Chan, G.; Sun, H.
    Glutathione and multidrug resistance protein transporter mediate a self-propelled disposal of bismuth in human cells (2015), Proc. Natl. Acad. Sci. USA, 112, 3211-3216 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Bi3+-glutathione[side 1] Homo sapiens
-
ADP + phosphate + Bi3+-glutathione[side 2]
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HK-2 cell
-
Homo sapiens
-
ML-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Bi3+-glutathione[side 1]
-
Homo sapiens ADP + phosphate + Bi3+-glutathione[side 2]
-
?

Synonyms

Synonyms Comment Organism
MRP transporter
-
Homo sapiens
multidrug resistance protein transporter
-
Homo sapiens

General Information

General Information Comment Organism
metabolism over 90% of bismuth is passively absorbed, conjugated to glutathione, and transported into vesicles by the enzyme Homo sapiens