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Literature summary for 7.6.2.3 extracted from

  • Karwatsky, J.; Daoud, R.; Cai, J.; Gros, P.; Georges, E.
    Binding of a photoaffinity analogue of glutathione to MRP1 (ABCC1) within two cytoplasmic regions (L0 and L1) as well as transmembrane domains 10-11 and 16-17 (2003), Biochemistry, 42, 3286-3294 .
    View publication on PubMed
Search for more literature for 7.6.2.3

Activating Compound

Activating Compound Comment Organism Structure
verapamil
-
 Homo sapiens
vincristine
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
doxorubicin
-
 Homo sapiens
GSH
-
 Homo sapiens
GSSG
-
 Homo sapiens
leukotriene C4
-
 Homo sapiens
MK571
-
 Homo sapiens
VP-16
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + glutathione-S-conjugate[side 1] Homo sapiens
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P33527
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + (aryl-azido)-glutathione[side 1]
-
 Homo sapiens ADP + phosphate + (aryl-azido)-glutathione[side 2]
-
 ?
ATP + H2O + (iodoaryl-azido)-glutathione[side 1]
-
 Homo sapiens ADP + phosphate + (iodoaryl-azido)-glutathione[side 2]
-
 ?
ATP + H2O + glutathione-S-conjugate[side 1]
-
 Homo sapiens ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
ATP + H2O + leukotriene C4[side 1]
-
 Homo sapiens ADP + phosphate + leukotriene C4[side 2]
-
 ?
ATP + H2O + MK571[side 1]
-
 Homo sapiens ADP + phosphate + MK571[side 2]
-
 ?
ATP + H2O + S-ethylglutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-ethylglutathione[side 2]
-
 ?
ATP + H2O + S-hexylglutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-hexylglutathione[side 2]
-
 ?
ATP + H2O + S-methylglutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-methylglutathione[side 2]
-
 ?
ATP + H2O + S-octylglutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-octylglutathione[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
ABCC1
-
 Homo sapiens
MRP1
-
 Homo sapiens
multidrug resistance-associated protein 1
-
 Homo sapiens