Literature summary for 7.6.2.3 extracted from

Raj, D.; Mu, J.; Jiang, H.; Kabat, J.; Singh, S.; Sullivan, M.; Fay, M.; McCutchan, T.; Su, X.
Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione (2009), J. Biol. Chem., 284, 7687-7696 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Plasmodium falciparum	16020	-
vesicle	-	Plasmodium falciparum	31982	-

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
gametocyte	-	Plasmodium falciparum	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + amodiaquine[side 1]	-	Plasmodium falciparum	ADP + phosphate + amodiaquine[side 2]	-	?
ATP + H2O + artemisinin[side 1]	-	Plasmodium falciparum	ADP + phosphate + artemisinin[side 2]	-	?
ATP + H2O + chloroquine[side 1]	-	Plasmodium falciparum	ADP + phosphate + chloroquine[side 2]	-	?
ATP + H2O + glutathione[side 1]	-	Plasmodium falciparum	ADP + phosphate + glutathione[side 2]	-	?
ATP + H2O + mefloquine[side 1]	-	Plasmodium falciparum	ADP + phosphate + mefloquine[side 2]	-	?
ATP + H2O + piperaquine[side 1]	-	Plasmodium falciparum	ADP + phosphate + piperaquine[side 2]	-	?
ATP + H2O + primaquine[side 1]	-	Plasmodium falciparum	ADP + phosphate + primaquine[side 2]	-	?
ATP + H2O + proguanil[side 1]	-	Plasmodium falciparum	ADP + phosphate + proguanil[side 2]	-	?
ATP + H2O + quinine[side 1]	-	Plasmodium falciparum	ADP + phosphate + quinine[side 2]	-	?

Subunits

Subunits	Comment	Organism
?	x * 214000, SDS-PAGE	Plasmodium falciparum

Synonyms

Synonyms	Comment	Organism
MRP	-	Plasmodium falciparum
multidrug resistance-associated protein	-	Plasmodium falciparum
Pgh-1	-	Plasmodium falciparum

General Information

General Information	Comment	Organism
physiological function	the enzyme plays a role in the efflux of glutathione or glutathione conjugates as well as chloroquine and quinine, and contributes to parasite responses to multiple antimalarial drugs by pumping drugs outside the parasite	Plasmodium falciparum

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Release 2023.1 (January 2023)