Reference on EC 3.6.5.2 - small monomeric GTPase and Organism(s) Homo sapiens and UniProt Accession P60763
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
topREF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sauvage, C.; Rumigny, J.F.; Maitre, M.
Purification and characterization of G proteins from human brain: modification of GTPase activity upon phosphorylation
Mol. Cell. Biochem.
107
65-77
1991
Homo sapiens
Haberland, J.; Gerke, V.
Conserved charged residues in the leucin-rich repeat domain of the Ran GTPase activating protein are required for Ran binding and GTPase activation
Biochem. J.
343
653-662
1999
Saccharomyces cerevisiae, Homo sapiens
Illenberger, D.; Schwald, F.; Pimmer, D.; Binder, W.; Maier, G.; Dietrich, A.; Gierschik, P.
Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1
EMBO J.
17
6241-6249
1998
Bos taurus, Homo sapiens
Gamblin S.J.; Smerdon, S.J.
GTPase-activating proteins and their complexes
Curr. Opin. Struct. Biol.
8
195-201
1998
Homo sapiens
Hall, A.
Rho GTPases and the actin cytoskeleton
Science
279
509-514
1998
Saccharomyces cerevisiae, Homo sapiens
Vitale, N.; Moss, J.; Vaughan, M.
Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1)
J. Biol. Chem.
273
2553-2560
1998
Homo sapiens
Rittinger, K.; Walker, P.A.; Eccleston, J.F.; Smerdon, S.J.; Gamblin, S.J.
Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue
Nature
389
758-762
1997
Homo sapiens
Polakis, P.G.; Rubinfeld, B.; Evans, T.; McCormick, F.
Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krec-1 from HL60 cells
Proc. Natl. Acad. Sci. USA
88
239-243
1991
Homo sapiens
Janoueix-Lerosey, I.; Polakis, P.; Tavitian, A.; de Gunzburg, J.
Regulation of the GTPase activity of the Ras-related Rap2 protein
Biochem. Biophys. Res. Commun.
189
455-464
1992
Homo sapiens
Geyer, M.; Wittinghofer, A.
GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding protein
Curr. Opin. Struct. Biol.
7
786-792
1997
Bos taurus, Homo sapiens, Rattus sp.
Fischer, R.; Wei, Y.; Anagli, J.; Berchtold, M.W.
Calmodulin binds to and inhibits GTP binding of the Ras-like GTPase Kir/Gem
J. Biol. Chem.
271
25067-25070
1996
Homo sapiens
Li, R.; Zhang, B.; Zheng, Y.
Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain p190
J. Biol. Chem.
272
32830-32835
1997
Homo sapiens
Jones, S.; Litt, R. J.; Richardson, C.J.; Segev, N.
Requirement of nucleotide exchange factor for Ypt1 GTPase mediated protein transport
J. Cell Biol.
130
1051-1061
1995
Saccharomyces cerevisiae, Homo sapiens
Quilliam, L.A.; Der, C.J.; Clark, R.; O'Rourke, E.C.; Zhang, K.; McCormick, F.; Bokoch, G.M.
Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins
Mol. Cell. Biol.
10
2901-2908
1990
Homo sapiens
Bourne, H.R.; Sanders, D.A.; McCormick, F.
The GTPase superfamily: conserved structure and molecular mechanism
Nature
349
117-127
1991
Saccharomyces cerevisiae, Oryctolagus cuniculus, Escherichia coli, Homo sapiens, Escherichia coli EF-Tu
Zhao, J.; Wang, W.N.; Tan, Y.C.; Zheng, Y.; Wang, Z.X.
Effect of Mg2+ on the kinetics of guanine nucleotide binding and hydrolysis by Cdc42
Biochem. Biophys. Res. Commun.
297
653-658
2002
Homo sapiens
Louro, R.; Nakaya, H.I.; Paquola, A.C.; Martins, E.A.; da Silva, A.M.; Verjovski-Almeida, S.; Reis, E.M.
RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors
Biochem. Biophys. Res. Commun.
316
618-627
2004
Homo sapiens (Q6T310), Homo sapiens (Q6T311), Homo sapiens
Menasche, G.; Feldmann, J.; Houdusse, A.; Desaymard, C.; Fischer, A.; Goud, B.; de Saint Basile, G.
Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients
Blood
101
2736-2742
2003
Homo sapiens
Haeusler, L.C.; Blumenstein, L.; Stege, P.; Dvorsky, R.; Ahmadian, M.R.
Comparative functional analysis of the Rac GTPases
FEBS Lett.
555
556-560
2003
Homo sapiens, Homo sapiens (P60763)
Wennerberg, K.; Der, C.J.
Rho-family GTPases: It's not only Rac and Rho (and I like it)
J. Cell Sci.
117
1301-1312
2004
Homo sapiens
Simpson, J.C.; Griffiths, G.; Wessling-Resnick, M.; Fransen, J.A.; Bennett, H.; Jones, A.T.
A role for the small GTPase Rab21 in the early endocytic pathway
J. Cell Sci.
117
6297-6311
2004
Homo sapiens (Q9UL25), Homo sapiens
Yu, Y.; Chang, Y.; Li, S.; Hu, H.; Huang, Q.; Ding, J.
Expression, purification, crystallization and preliminary structural characterization of the GTPase domain of human Rheb
Acta Crystallogr. Sect. D
D60
1883-1887
2004
Homo sapiens
Yanuar, A.; Sakurai, S.; Kitano, K.; Hakoshima, T.
Expression, purification, crystallization and preliminary crystallographic analysis of human Rad GTPase
Acta Crystallogr. Sect. F
F61
978-980
2005
Homo sapiens
Paganini, S.; Guidetti, G.F.; Catricala, S.; Trionfini, P.; Panelli, S.; Balduini, C.; Torti, M.
Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins
Biochimie
88
285-295
2006
Homo sapiens
Zou, H.; Hu, L.; Li, J.; Zhan, S.; Cao, K.
Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential
Biotechnol. Lett.
28
1901-1908
2006
Homo sapiens
Huber, S.K.; Scheidig, A.J.
High resolution crystal structures of human Rab4a in its active and inactive conformations
FEBS Lett.
579
2821-2829
2005
Homo sapiens
Yanuar, A.; Sakurai, S.; Kitano, K.; Hakoshima, T.
Crystal structure of human Rad GTPase of the RGK-family
Genes Cells
11
961-968
2006
Homo sapiens
Shutes, A.; Berzat, A.C.; Chenette, E.J.; Cox, A.D.; Der, C.J.
Biochemical analyses of the Wrch atypical Rho family GTPases
Methods Enzymol.
406
11-26
2006
Homo sapiens
Yuan, J.; Shan, Y.; Chen, X.; Tang, W.; Luo, K.; Ni, J.; Wan, B.; Yu, L.
Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B
Mol. Biol. Rep.
32
205-214
2005
Homo sapiens (Q8TAI7)
Li, Y.; Inoki, K.; Guan, K.L.
Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
Mol. Cell. Biol.
24
7965-7975
2004
Homo sapiens
Hirai, F.; Nakayamada, S.; Okada, Y.; Saito, K.; Kurose, H.; Mogami, A.; Tanaka, Y.
Small GTPase Rho signaling is involved in beta1 integrin-mediated up-regulation of intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation
Biochem. Biophys. Res. Commun.
356
279-285
2007
Homo sapiens
Nikolova, E.; Mitev, V.; Zhelev, N.; Deroanne, C.F.; Poumay, Y.
The small Rho GTPase Rac1 controls normal human dermal fibroblasts proliferation with phosphorylation of the oncoprotein c-myc
Biochem. Biophys. Res. Commun.
359
834-839
2007
Homo sapiens
Liao, J.; Shima, F.; Araki, M.; Ye, M.; Muraoka, S.; Sugimoto, T.; Kawamura, M.; Yamamoto, N.; Tamura, A.; Kataoka, T.
Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics
Biochem. Biophys. Res. Commun.
369
327-332
2008
Homo sapiens, Mus musculus, Suberites domuncula (A1XKQ5), Suberites domuncula (A1XKQ6), Suberites domuncula (A1XKQ7), Suberites domuncula (A1XKQ8), Suberites domuncula (A1XKQ9), Suberites domuncula (A1XKR0), Suberites domuncula (A1XKR1), Suberites domuncula (A1XKR2), Suberites domuncula (A1XKR3), Suberites domuncula (A1XKR5), Suberites domuncula (A1XKR6), Suberites domuncula (A1XKR7), Suberites domuncula (A1XKR8), Suberites domuncula (A1XKR9), Suberites domuncula (A1XKS0), Suberites domuncula (A1XKS1), Suberites domuncula (A1XKS2), Suberites domuncula (A1XKS3), Suberites domuncula (A1XKS4), Suberites domuncula (A1XKS5), Suberites domuncula (A1XKS6), Suberites domuncula (A1XKS7), Suberites domuncula (A1XKS8), Suberites domuncula (A1XKS9), Suberites domuncula (A1XKT0), Suberites domuncula (A1XKT1), Suberites domuncula (A1XKT2), Suberites domuncula (A1XKT3), Suberites domuncula (A1XKT4), Suberites domuncula (A1XKT5), Suberites domuncula (A1XKT6), Suberites domuncula (A1XKT7), Suberites domuncula (A1XKT8), Suberites domuncula (A1XKT9), Suberites domuncula (A1XKU0), Suberites domuncula (A1XKU1), Suberites domuncula (A1XKU2), Suberites domuncula (A1XKU3), Suberites domuncula (A1XKU4), Suberites domuncula (A1XKU5), Suberites domuncula (O97342), Suberites domuncula (Q4H115), Suberites domuncula (Q4H116)
Fu, D.; van Dam, E.M.; Brymora, A.; Duggin, I.G.; Robinson, P.J.; Roufogalis, B.D.
The small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein
Biochim. Biophys. Acta
1773
1062-1072
2007
Homo sapiens
Miyano, K.; Sumimoto, H.
Role of the small GTPase Rac in p22phox-dependent NADPH oxidases
Biochimie
89
1133-1144
2007
Homo sapiens
de Gorter, D.J.; Reijmers, R.M.; Beuling, E.A.; Naber, H.P.; Kuil, A.; Kersten, M.J.; Pals, S.T.; Spaargaren, M.
The de Gorter, D.J.; Reijmers, R.M.; Beuling, E.A.; Naber, H.P.; Kuil, A.; Kersten, M.J.; Pals, S.T.; Spaargaren, M.: The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells
Blood
111
3364-3372
2008
Homo sapiens
Burguete, A.S.; Fenn, T.D.; Brunger, A.T.; Pfeffer, S.R.
Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185
Cell
132
286-298
2008
Homo sapiens
Crema, V.O.; Hamassaki, D.E.; Santos, M.F.
Small Rho GTPases are important for acinus formation in a human salivary gland cell line
Cell Tissue Res.
325
493-500
2006
Homo sapiens
Martinez-Salgado, C.; Rodriguez-Pena, A.B.; Lopez-Novoa, J.M.
Involvement of small Ras GTPases and their effectors in chronic renal disease
Cell. Mol. Life Sci.
65
477-492
2008
Homo sapiens, Mus musculus
Selvakumar, B.; Hess, D.T.; Goldschmidt-Clermont, P.J.; Stamler, J.S.
Co-regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac
FEBS Lett.
582
2195-2202
2008
Homo sapiens
Miyano, K.; Ueno, N.; Takeya, R.; Sumimoto, H.
Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1
J. Biol. Chem.
281
21857-21868
2006
Homo sapiens
Kawato, M.; Shirakawa, R.; Kondo, H.; Higashi, T.; Ikeda, T.; Okawa, K.; Fukai, S.; Nureki, O.; Kita, T.; Horiuchi, H.
Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway
J. Biol. Chem.
283
166-174
2008
Homo sapiens
Dada, L.A.; Novoa, E.; Lecuona, E.; Sun, H.; Sznajder, J.I.
Role of the small GTPase RhoA in the hypoxia-induced decrease of plasma membrane Na,K-ATPase in A549 cells
J. Cell Sci.
120
2214-2222
2007
Homo sapiens
Scapin, S.M.; Carneiro, F.R.; Alves, A.C.; Medrano, F.J.; Guimaraes, B.G.; Zanchin, N.I.
The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform
J. Struct. Biol.
154
260-268
2006
Homo sapiens
Koziel, H.
Rho GTPases in alveolar macrophage phagocytosis
Methods Enzymol.
439
303-313
2008
Homo sapiens
Clarke, P.R.; Zhang, C.
Spatial and temporal coordination of mitosis by Ran GTPase
Nat. Rev. Mol. Cell Biol.
9
464-477
2008
Homo sapiens, Mus musculus
Kobayashi, T.; Hori, Y.; Ueda, N.; Kajiho, H.; Muraoka, S.; Shima, F.; Kataoka, T.; Kontani, K.; Katada, T.
Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome
Biochem. Biophys. Res. Commun.
381
439-442
2009
Homo sapiens
Fenwick, R.; Prasannan, S.; Campbell, L.; Nietlispach, D.; Evetts, K.; Camonis, J.; Mott, H.; Owen, D.
Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding
Biochemistry
48
2192-2206
2009
Homo sapiens
Li, H.; Ung, C.Y.; Ma, X.H.; Li, B.W.; Low, B.C.; Cao, Z.W.; Chen, Y.Z.
Simulation of crosstalk between small GTPase RhoA and EGFR-ERK signaling pathway via MEKK1
Bioinformatics
25
358-364
2009
Homo sapiens
Carmona, G.; Goettig, S.; Orlandi, A.; Scheele, J.; Baeuerle, T.; Jugold, M.; Kiessling, F.; Henschler, R.; Zeiher, A.M.; Dimmeler, S.; Chavakis, E.
Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis
Blood
113
488-497
2009
Homo sapiens, Mus musculus
Nie, D.; Guo, Y.; Yang, D.; Tang, Y.; Chen, Y.; Wang, M.T.; Zacharek, A.; Qiao, Y.; Che, M.; Honn, K.V.
Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho
Cancer Res.
68
115-121
2008
Homo sapiens
Fueller, F.; Kubatzky, K.F.
The small GTPase RhoH is an atypical regulator of haematopoietic cells
Cell Commun. Signal.
6
6-6
2008
Homo sapiens (Q15669), Homo sapiens, Mus musculus (Q9D3G9), Mus musculus
Lu, Q.; Longo, F.M.; Zhou, H.; Massa, S.M.; Chen, Y.H.
Signaling through Rho GTPase pathway as viable drug target
Curr. Med. Chem.
16
1355-1365
2009
Homo sapiens
He, H.; Baldwin, G.S.
Rho GTPases and p21-activated kinase in the regulation of proliferation and apoptosis by gastrins
Int. J. Biochem. Cell Biol.
40
2018-2022
2008
Homo sapiens
Yin, J.; Lu, J.; Yu, F.S.
Role of small GTPase Rho in regulating corneal epithelial wound healing
Invest. Ophthalmol. Vis. Sci.
49
900-909
2008
Homo sapiens, Sus scrofa
Birukov, K.G.
Small GTPases in mechanosensitive regulation of endothelial barrier
Microvasc. Res.
77
46-52
2009
Homo sapiens
Hayes, G.L.; Brown, F.C.; Haas, A.K.; Nottingham, R.M.; Barr, F.A.; Pfeffer, S.R.
Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi
Mol. Biol. Cell
20
209-217
2009
Homo sapiens
Higashi, M.; Ishikawa, C.; Yu, J.; Toyoda, A.; Kawana, H.; Kurokawa, K.; Matsuda, M.; Kitagawa, M.; Harigaya, K.
Human Mena associates with Rac1 small GTPase in glioblastoma cell lines
PLoS ONE
4
e4765
2009
Homo sapiens
Fueller, F.; Schmidt, G.
The polybasic region of Rho GTPases defines the cleavage by Yersinia enterocolitica outer protein T (YopT)
Protein Sci.
17
1456-1462
2008
Homo sapiens
Jeyaraj, S.C.; Unger, N.T.; Chotani, M.A.
Rap1 GTPases: an emerging role in the cardiovasculature
Life Sci.
88
645-652
2011
Homo sapiens, Mus musculus
Zoppino, F.C.; Militello, R.D.; Slavin, I.; Alvarez, C.; Colombo, M.I.
Autophagosome formation depends on the small GTPase Rab1 and functional ER exit sites
Traffic
11
1246-1261
2010
Homo sapiens
Kopra, K.; Ligabue, A.; Wang, Q.; Syrjaenpaeae, M.; Blazevits, O.; Veltel, S.; van Adrichem, A.J.; Haenninen, P.; Abankwa, D.; Haermae, H.
A homogeneous quenching resonance energy transfer assay for the kinetic analysis of the GTPase nucleotide exchange reaction
Anal. Bioanal. Chem.
406
4147-4156
2014
Homo sapiens (P01112), Homo sapiens (P01116), Homo sapiens (P61586)
Lee, M.N.; Koh, A.; Park, D.; Jang, J.H.; Kwak, D.; Jeon, H.; Kim, J.; Choi, E.J.; Jeong, H.; Suh, P.G.; Ryu, S.H.
Deacetylated alphabeta-tubulin acts as a positive regulator of Rheb GTPase through increasing its GTP-loading
Cell. Signal.
25
539-551
2013
Homo sapiens (Q15382)
Hsiao, B.Y.; Chang, T.K.; Wu, I.T.; Chen, M.Y.
Rad GTPase inhibits the NFkappaB pathway through interacting with RelA/p65 to impede its DNA binding and target gene transactivation
Cell. Signal.
26
1437-1444
2014
Homo sapiens
Huelsenbeck, S.C.; Roggenkamp, D.; May, M.; Huelsenbeck, J.; Brakebusch, C.; Rottner, K.; Ladwein, M.; Just, I.; Fritz, G.; Schmidt, G.; Genth, H.
Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1
Int. J. Biochem. Cell Biol.
45
1767-1775
2013
Homo sapiens (P62745), Mus musculus (P62746), Mus musculus
Aizawa, M.; Fukuda, M.
Small GTPase Rab2B and its specific binding protein Golgi-associated Rab2B interactor-like 4 (GARI-L4) regulate Golgi morphology
J. Biol. Chem.
290
22250-22261
2015
Homo sapiens (P61006), Homo sapiens (P61019), Homo sapiens (P62820), Homo sapiens (Q8WUD1), Homo sapiens (Q9H0U4), Homo sapiens (Q9NRW1), Homo sapiens
Ferri, N.; Contini, A.; Bernini, S.K.; Corsini, A.
Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors
J. Cardiovasc. Pharmacol.
62
425-435
2013
Homo sapiens (P15153), Homo sapiens (P60763), Homo sapiens (P63000)
Shen, D.W.; Pouliot, L.M.; Gillet, J.P.; Ma, W.; Johnson, A.C.; Hall, M.D.; Gottesman, M.M.
The transcription factor GCF2 is an upstream repressor of the small GTPAse RhoA, regulating membrane protein trafficking, sensitivity to doxorubicin, and resistance to cisplatin
Mol. Pharm.
9
1822-1833
2012
Homo sapiens (P61586), Homo sapiens
Tsai, C.H.; Cheng, H.C.; Wang, Y.S.; Lin, P.; Jen, J.; Kuo, I.Y.; Chang, Y.H.; Liao, P.C.; Chen, R.H.; Yuan, W.C.; Hsu, H.S.; Yang, M.H.; Hsu, M.T.; Wu, C.Y.; Wang, Y.C.
Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis
Nat. Commun.
5
4804
2014
Homo sapiens (Q96AX2), Homo sapiens
Schaefer, A.; Reinhard, N.R.; Hordijk, P.L.
Toward understanding RhoGTPase specificity: structure, function and local activation
Small GTPases
5
6
2014
Homo sapiens (P08134), Homo sapiens (P61586), Homo sapiens (P62745)
Spuul, P.; Ciufici, P.; Veillat, V.; Leclercq, A.; Daubon, T.; Kramer, I.; Genot, E.
Importance of RhoGTPases in formation, characteristics, and functions of invadosomes
Small GTPases
5
e28195
2014
Homo sapiens (P15153), Homo sapiens (P60953), Homo sapiens (P61586), Homo sapiens (P63000)
Knihtila, R.; Volmar, A.Y.; Meilleur, F.; Mattos, C.
Titration of ionizable groups in proteins using multiple neutron data sets from a single crystal application to the small GTPase Ras
Acta Crystallogr. Sect. F
75
111-115
2019
Homo sapiens
Zhang, L.; Dai, F.; Cui, L.; Zhou, B.; Guo, Y.
Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells
Biochim. Biophys. Acta
1864
613-624
2017
Homo sapiens (P51153), Homo sapiens
Yoo, J.; Brady, S.; Acosta-Alvarez, L.; Rogers, A.; Peng, J.; Sorensen, L.; Wolff, R.; Mleynek, T.; Shin, D.; Rich, C.; Kircher, D.; Bild, A.; Odelberg, S.; Li, D.; Holmen, S.; Grossmann, A.
The small GTPase ARf6 activates PI3K in melanoma to induce a prometastatic state
Cancer Res.
79
2892-2908
2019
Homo sapiens (P62330), Homo sapiens, Mus musculus (P62331)
Francis, J.W.; Newman, L.E.; Cunningham, L.A.; Kahn, R.A.
A trimer consisting of the tubulin-specific chaperone D (TBCD), regulatory GTPase ARL2, and beta-tubulin is required for maintaining the microtubule network
J. Biol. Chem.
292
4336-4349
2017
Homo sapiens (P36404), Homo sapiens
Esposito, A.; Ventura, V.; Petoukhov, M.; Rai, A.; Svergun, D.; Vanoni, M.
Human MICAL1 activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8
Protein Sci.
28
150-166
2019
Homo sapiens (P61006), Homo sapiens
