Activating Compound | Comment | Organism | Structure |
---|---|---|---|
GTPase activating protein GAP | for Ras-related proteins, stimulates intrinsic GTPase reaction | Homo sapiens | |
GTPase activating protein GAP | for Ras-related proteins, stimulates intrinsic GTPase reaction | Bos taurus | |
GTPase activating protein GAP | for Ras-related proteins, stimulates intrinsic GTPase reaction | Rattus sp. | |
guanine nucleotide exchange factor GEF | facilitates loading with GTP | Homo sapiens | |
guanine nucleotide exchange factor GEF | facilitates loading with GTP | Bos taurus | |
guanine nucleotide exchange factor GEF | facilitates loading with GTP | Rattus sp. |
Crystallization (Comment) | Organism |
---|---|
Arf1 complexed to GDP, common G domain topology | Homo sapiens |
Arf1, complexed to GDP, common G domain topology | Rattus sp. |
Rac1, active conformation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
guanine nucleotide dissociation inhibitor GDI | - |
Bos taurus | |
guanine nucleotide dissociation inhibitor GDI | down-regulating GTPase activity, inhibition of nucleotide dissociation | Homo sapiens | |
guanine nucleotide dissociation inhibitor GDI | down-regulating GTPase activity, inhibition of nucleotide dissociation | Rattus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Homo sapiens | increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP | GDP + phosphate | - |
ir | |
GTP + H2O | Bos taurus | increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP | GDP + phosphate | - |
ir | |
GTP + H2O | Rattus sp. | increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP | GDP + phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus sp. | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | increased rate of nucleotide dissociation by interaction with guanosine exchange factors that facilitates loading with GTP | Homo sapiens | GDP + phosphate | - |
ir | |
GTP + H2O | increased rate of nucleotide dissociation by interaction with guanosine exchange factors that facilitates loading with GTP | Bos taurus | GDP + phosphate | - |
ir | |
GTP + H2O | increased rate of nucleotide dissociation by interaction with guanosine exchange factors that facilitates loading with GTP | Rattus sp. | GDP + phosphate | - |
ir | |
GTP + H2O | increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP | Homo sapiens | GDP + phosphate | - |
ir | |
GTP + H2O | increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP | Bos taurus | GDP + phosphate | - |
ir | |
GTP + H2O | increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP | Rattus sp. | GDP + phosphate | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
Arf 1 | - |
Homo sapiens |
Arf 1 | - |
Rattus sp. |
Rac1 | Rho subfamily | Homo sapiens |
Rac1 | Rho subfamily | Bos taurus |
Ran | Ras-related, participating in nucleocytoplasmatic transport | Homo sapiens |
RAS | - |
Homo sapiens |
RAS | - |
Bos taurus |
RAS | - |
Rattus sp. |