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Literature summary for 3.6.5.2 extracted from

  • Louro, R.; Nakaya, H.I.; Paquola, A.C.; Martins, E.A.; da Silva, A.M.; Verjovski-Almeida, S.; Reis, E.M.
    RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors (2004), Biochem. Biophys. Res. Commun., 316, 618-627.
    View publication on PubMed
Search for more literature for 3.6.5.2

Application

Application Comment Organism
medicine potential target for cancer therapeutics Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
complete coding sequence of ARL9, from testis, maps to chromosome 4q12 Homo sapiens
complete coding sequence of RASL11A, from prostate, maps to chromosome 13q12.2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens RASL11A is down-regulated in prostate tumors and may have a tumor suppressor role in prostate cancer ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6T310 two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb
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Homo sapiens Q6T311
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-

Reaction

Reaction Comment Organism Reaction ID
GTP + H2O = GDP + phosphate a family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase, EC 3.6.1.46, they are involved in cell-growth regulation, Ras subfamily, membrane vesicle traffic and uncoating, Rab and ARF subfamilies, nuclear protein import, Ran subfamily, and organization of the cytoskeleton, Rho and Rac subfamilies Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
bladder two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb Homo sapiens
-
colon two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb Homo sapiens
-
additional information the RASL11A transcript is ubiquitously expressed in human tissues, no expression in thymus and leukocytes Homo sapiens
-
ovary very weak expression of RASL11A Homo sapiens
-
prostate adjacent, two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb, the abundance of the RASL11A transcript is diminished in prostate tumors in comparison to normal adjacent prostate tissue Homo sapiens
-
testis
-
 Homo sapiens
-
testis two isoforms of RASL11A transcript with different sizes of 1.6 and 1.2 kb Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ?
additional information RASL11A is down-regulated in prostate tumors and may have a tumor suppressor role in prostate cancer Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Arl9 ADP-ribosylation factor-like 9 Homo sapiens
More member of a novel small monomeric GTPase gene family Homo sapiens
Rasl11a RAS-like, family 11, member A Homo sapiens