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Literature summary for 3.6.5.2 extracted from
- Rho GTPases and p21-activated kinase in the regulation of proliferation and apoptosis by gastrins (2008), Int. J. Biochem. Cell Biol., 40, 2018-2022.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| p21-activated kinase 1 | interacts with Rac and Cdc42 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| p21-activated kinase 1 + H2O | Homo sapiens | Gamide signals Rac/Cdc42 to activate p21-activated kinase 1 | activated p21-activated kinase 1 + ? | - |
? |  |
| Rho-activated kinase + H2O | Homo sapiens | Ggly signals Rac/Cdc42 to activate Rho-activated kinase | activated Rho-activated kinase + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| p21-activated kinase 1 + H2O | Gamide signals Rac/Cdc42 to activate p21-activated kinase 1 | Homo sapiens | activated p21-activated kinase 1 + ? | - |
? | |
| Rho-activated kinase + H2O | Ggly signals Rac/Cdc42 to activate Rho-activated kinase | Homo sapiens | activated Rho-activated kinase + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdc42 | - |
Homo sapiens |
| Rac | - |
Homo sapiens |
| Rho | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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