Literature summary for 3.6.5.2 extracted from

Fischer, R.; Wei, Y.; Anagli, J.; Berchtold, M.W.
Calmodulin binds to and inhibits GTP binding of the Ras-like GTPase Kir/Gem (1996), J. Biol. Chem., 271, 25067-25070.

Search for more literature for 3.6.5.2

Protein Variants

Protein Variants	Comment	Organism
N-terminal truncation	Kir/Gem peptide, C-terminal calmodulin-binding domain, high affinity for dansyl-calmodulin	Homo sapiens
W269G	Kir/Gem peptide, abolish affinity for dansyl-calmodulin	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Calmodulin	binding of calmodulin to GST-immobilized Kir/Gem peptide inhibits GTP binding	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP + H2O	Homo sapiens	-	GDP + phosphate	-	ir

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Homo sapiens	GDP + phosphate	-	ir

Synonyms

Synonyms	Comment	Organism
Gem	Ras-related, involved in receptor-mediated signal transduction at the plasma membrane	Homo sapiens
Kir	Ras-related, involved in processes of invasion or metastasis in mammalia cells	Homo sapiens
Rad	Ras-related, involved in skeletal muscle motor function	Homo sapiens

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Release 2023.1 (January 2023)