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Literature summary for 3.6.5.2 extracted from
- Rho GTPases and the actin cytoskeleton (1998), Science, 279, 509-514.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Cdc42 | activation of Rac | Saccharomyces cerevisiae | |
| GTPase activating protein GAP | - |
Homo sapiens | |
| GTPase activating protein GAP | - |
Saccharomyces cerevisiae | |
| guanine nucleotide exchange factor GEF | activation of RhoGTPases through direct protein-protein interaction | Homo sapiens | |
| guanine nucleotide exchange factor GEF | activation of RhoGTPases through direct protein-protein interaction | Saccharomyces cerevisiae | |
| Insulin | activation of Rac, assembly of actin filaments | Homo sapiens | |
| lysophosphatidic acid | activation of Rho, assembly of contractile actin-myosin filaments and focal adhesion complexes | Saccharomyces cerevisiae |  |
| platelet derived growth factor | Rac activation, assembly of actin filaments | Homo sapiens | |
| Rac | activation of Rho, cross-talk between Ras- and Rho subfamilies | Saccharomyces cerevisiae | |
| Ras | cross-talk between Ras- and Rho subfamilies, activation of Rac | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| guanine nucleotide dissociation inhibitor GDI | down-regulating GTPase activity, inhibition of nucleotide dissociation | Homo sapiens | |
| guanine nucleotide dissociation inhibitor GDI | down-regulating GTPase activity, inhibition of nucleotide dissociation | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | Rho GTPase, partially cytosolic in association with guanine nucleotide dissociation inhibitor | Saccharomyces cerevisiae | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Homo sapiens | - |
GDP + phosphate | - |
ir | |
| GTP + H2O | Saccharomyces cerevisiae | - |
GDP + phosphate | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
ir | |
| GTP + H2O | - |
Saccharomyces cerevisiae | GDP + phosphate | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heteromer | - |
Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdc42 | Rho subfamily | Homo sapiens |
| Cdc42 | Rho subfamily | Saccharomyces cerevisiae |
| Cdc42Hs | Rho subfamily | Homo sapiens |
| Rac1 | Rho subfamily | Homo sapiens |
| Rac1 | Rho subfamily | Saccharomyces cerevisiae |
| Ran | - |
Homo sapiens |
| RhoA | Rho subfamily | Homo sapiens |
| RhoA | Rho subfamily | Saccharomyces cerevisiae |
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