Literature summary for 3.6.5.2 extracted from

Tsai, C.H.; Cheng, H.C.; Wang, Y.S.; Lin, P.; Jen, J.; Kuo, I.Y.; Chang, Y.H.; Liao, P.C.; Chen, R.H.; Yuan, W.C.; Hsu, H.S.; Yang, M.H.; Hsu, M.T.; Wu, C.Y.; Wang, Y.C.
Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis (2014), Nat. Commun., 5, 4804.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	Rab proteins are members of the Ras superfamily of GTPases that switch between GDP-bound (inactive) and GTP-bound (active) forms	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	quantitative analyses of vesicular stomatitis virus ts045 G protein fused to green fluorescent protein exocytosis from endoplasmic reticulum through the Golgi to the PM22,23 in Rab37 knockdown (Rab37KD) or control COS1 cells	Homo sapiens
Q89L	site-directed mutagenesis, a GTP-bound active mutant	Homo sapiens
T43N	site-directed mutagenesis, a GDP-bound inactive mutant	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	Rab proteins are members of the Ras superfamily of GTPases that switch between GDP-bound (inactive) and GTP-bound (active) forms	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
secretory vesicle	colocalization with tissue inhibitor of metalloproteinase 1 (TIMP1)	Homo sapiens	99503	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP + H2O	Homo sapiens	-	GDP + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96AX2	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
CL1-5 cell	-	Homo sapiens	-
lung cancer cell	lung cancer patients with metastasis and poor survival show low hRAB37 protein expression coinciding with low TIMP1 in tumours, hRAB37 is downregulated mainly by promoter hypermethylation in lung cancer cells and patients, low mRNA expression of hRAB37 gene is associated with tumour metastasis in lung cancer patients	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Homo sapiens	GDP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
Rab37	-	Homo sapiens
small GTPase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	hRAB37 is downregulated mainly by promoter hypermethylation in lung cancer cells	down

General Information

General Information	Comment	Organism
evolution	Rab proteins are members of the Ras superfamily of GTPases that switch between GDP-bound (inactive) and GTP-bound (active) forms	Homo sapiens
malfunction	Dysfunction of hRAB37 or TIMP1 abrogates metastasis suppression	Homo sapiens
physiological function	Rab small GTPases are master regulators of membrane trafficking and guide vesicle targeting. Rab proteins transport cargo proteins to target membrane, organelle and cellular compartment to coordinate the cell membrane dynamics, cytoskeleton organization, signal transduction and membrane trafficking. Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 (TIMP1) for exocytosis and thus suppresses tumour metastasis in a nucleotide-dependent manner. hRAB37 is involved in transportation of exocytotic vesicles and is involved in the exocytotic pathway of nascent secretory protein from the Golgi to the plasma membrane but not in the recycling endosome-mediated secretory pathway. Tissue inhibitor of metalloproteinase 1 is a secreted protein that inhibits MMPs and extracellular matrix turnover thereby decreasing cell motility. Rab-controlled trafficking pathways are altered during tumorigenesis. Tissue inhibitor of metalloproteinase 1 (TIMP1), a secreted glycoprotein that inhibits extracellular matrix turnover, is a cargo of hRAB37. hRAB37 regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate matrix metalloproteinase 9 (MMP9) migration axis in vitro and in vivo	Homo sapiens

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Release 2023.1 (January 2023)