Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | Rab proteins are members of the Ras superfamily of GTPases that switch between GDP-bound (inactive) and GTP-bound (active) forms | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | quantitative analyses of vesicular stomatitis virus ts045 G protein fused to green fluorescent protein exocytosis from endoplasmic reticulum through the Golgi to the PM22,23 in Rab37 knockdown (Rab37KD) or control COS1 cells | Homo sapiens |
Q89L | site-directed mutagenesis, a GTP-bound active mutant | Homo sapiens |
T43N | site-directed mutagenesis, a GDP-bound inactive mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | Rab proteins are members of the Ras superfamily of GTPases that switch between GDP-bound (inactive) and GTP-bound (active) forms | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
secretory vesicle | colocalization with tissue inhibitor of metalloproteinase 1 (TIMP1) | Homo sapiens | 99503 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Homo sapiens | - |
GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96AX2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CL1-5 cell | - |
Homo sapiens | - |
lung cancer cell | lung cancer patients with metastasis and poor survival show low hRAB37 protein expression coinciding with low TIMP1 in tumours, hRAB37 is downregulated mainly by promoter hypermethylation in lung cancer cells and patients, low mRNA expression of hRAB37 gene is associated with tumour metastasis in lung cancer patients | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Rab37 | - |
Homo sapiens |
small GTPase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | hRAB37 is downregulated mainly by promoter hypermethylation in lung cancer cells | down |
General Information | Comment | Organism |
---|---|---|
evolution | Rab proteins are members of the Ras superfamily of GTPases that switch between GDP-bound (inactive) and GTP-bound (active) forms | Homo sapiens |
malfunction | Dysfunction of hRAB37 or TIMP1 abrogates metastasis suppression | Homo sapiens |
physiological function | Rab small GTPases are master regulators of membrane trafficking and guide vesicle targeting. Rab proteins transport cargo proteins to target membrane, organelle and cellular compartment to coordinate the cell membrane dynamics, cytoskeleton organization, signal transduction and membrane trafficking. Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 (TIMP1) for exocytosis and thus suppresses tumour metastasis in a nucleotide-dependent manner. hRAB37 is involved in transportation of exocytotic vesicles and is involved in the exocytotic pathway of nascent secretory protein from the Golgi to the plasma membrane but not in the recycling endosome-mediated secretory pathway. Tissue inhibitor of metalloproteinase 1 is a secreted protein that inhibits MMPs and extracellular matrix turnover thereby decreasing cell motility. Rab-controlled trafficking pathways are altered during tumorigenesis. Tissue inhibitor of metalloproteinase 1 (TIMP1), a secreted glycoprotein that inhibits extracellular matrix turnover, is a cargo of hRAB37. hRAB37 regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate matrix metalloproteinase 9 (MMP9) migration axis in vitro and in vivo | Homo sapiens |