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Literature summary for 3.6.5.2 extracted from

  • Simpson, J.C.; Griffiths, G.; Wessling-Resnick, M.; Fransen, J.A.; Bennett, H.; Jones, A.T.
    A role for the small GTPase Rab21 in the early endocytic pathway (2004), J. Cell Sci., 117, 6297-6311.
    View publication on PubMed
Search for more literature for 3.6.5.2

Cloned(Commentary)

Cloned (Comment) Organism
Rab21 cDNA from K-562 cell, expression in HeLa cells CCL-2 and in hepatocellular carcinoma Hep3B cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
Q78L mutant is defective in GTP hydrolysis, subcellular distribution Homo sapiens
T33N mutant enzyme is defective in GTP binding, cells expressing mutant Rab21 show defects in endocytosis of transferrin and epidermal growth factor and fail to effectively deliver the latter ligand to late endosomes and lysosomes for degradation, subcellular distribution Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endocytic vesicle Rab21 is predominantly localized to the early endocytic pathway, on vesicles containing early-endosomal antigen 1, transferrin receptor and internalized ligands Homo sapiens 30139
-
additional information subcellular distribution of wild-type, T33N and Q78L mutant Rab21 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51000
-
 x * 51000, GFP-Rab21, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Homo sapiens Rab21 has a role in the dynamics of the early endocytic pathway GDP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UL25
-
-

Source Tissue

Source Tissue Comment Organism Textmining
K-562 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ?
GTP + H2O Rab21 has a role in the dynamics of the early endocytic pathway Homo sapiens GDP + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 51000, GFP-Rab21, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Rab21
-
 Homo sapiens