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Information on EC 3.2.1.28 - alpha,alpha-trehalase
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3.2.1.28 alpha,alpha-trehalaseIUBMB Comments
The enzyme is an anomer-inverting glucosidase that catalyses the hydrolysis of the alpha-glucosidic O-linkage of alpha,alpha-trehalose, releasing initially equimolar amounts of alpha- and beta-D-glucose. It is widely distributed in microorganisms, plants, invertebrates and vertebrates.
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Word Map
- 3.2.1.28
- sucrase
- lactase
- border
- larvae
- disaccharidase
-
brush
- trehalose-6-phosphate
- glycogen
- midgut
- glucoamylase
- hemolymph
-
camp-dependent
- validamycin
- chitin
- isomaltase
- silkworm
- alpha-glucosidase
-
instar
- bombyx
-
brush-border
- gamma-glutamyltransferase
- sucrase-isomaltase
- microvillar
- lepidoptera
-
carbohydrases
- molitor
- tenebrio
- 20-hydroxyecdysone
-
diapause
- metarhizium
- cellobiase
- planthopper
- ascospores
- analysis
- diagnostics
- synthesis
- agriculture
- medicine
- biotechnology
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
trehalase, neutral trehalase, acid trehalase, soluble trehalase, tre-2, nth1p, alpha,alpha-trehalase, setre-2, atc1p, ntp1p, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acid (non regulatory) trehalase
acid trehalase
alpha,alpha'-trehalose 1-D-glucohydrolase
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Alpha,alpha-trehalase
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-
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Alpha,alpha-trehalose glucohydrolase
alpha-glucoside-1-glucohydrolase
ATC1
Atc1p
Ath1
glucose alpha-1,1-glucose hydrolase
MSMEG 4528
neutral trehalase
Ntc1p
NTH1
Tre-2
TRE1
TreA
trehalase
Alpha,alpha-trehalose glucohydrolase
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-
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trehalase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose
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-
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alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose
role of carboxyl, guanidine and imidazole groups in catalysis
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alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose
nucleophilic double, not single, displacement catalytic forward reaction mechanism via oxocarbenium ion intermediate, detailed overview
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of O-glycosyl bond
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-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
alpha,alpha-trehalose glucohydrolase
The enzyme is an anomer-inverting glucosidase that catalyses the hydrolysis of the alpha-glucosidic O-linkage of alpha,alpha-trehalose, releasing initially equimolar amounts of alpha- and beta-D-glucose. It is widely distributed in microorganisms, plants, invertebrates and vertebrates.
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CAS REGISTRY NUMBER
COMMENTARY
9025-52-9
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha,alpha-trehalose + H2O
2 D-glucose
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the enzyme is involved in incorporation and utilization of trehalose
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-
?
alpha,alpha-trehalose + H2O
2 D-glucose
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the enzyme is essential for growth on trehalose as carbon source, regulation by D-glucose repression
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-
?
alpha,alpha-trehalose + H2O
2 D-glucose
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the enzyme is important in insect metabolism with trehalose being the main circulating sugar in the organism with functions in storage, fuel for flight, and as a cryoprotector, in hemolymph trehalose is important for carbohydrate intake and nutritional homeostasis, enzyme deficiency leads to severe metabolic problems
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-
?
alpha,alpha-trehalose + H2O
2 D-glucose
-
the enzyme is important in insect metabolism with trehalose being the main circulating sugar in the organism with functions in storage, fuel for flight, and as a cryoprotector, in hemolymph trehalose is important for carbohydrate intake and nutritional homeostasis, enzyme deficiency leads to severe metabolic problems
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-
?
alpha,alpha-trehalose + H2O
2 D-glucose
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highly specific for alpha,alpha-trehalose
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-
?
alpha,alpha-trehalose + H2O
2 D-glucose
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highly specific for alpha,alpha-trehalose
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-
?
alpha,alpha-trehalose + H2O
2 D-glucose
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both isoforms are highly specific for trehalose
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-
?
alpha,alpha-trehalose + H2O
2 D-glucose
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preferred substrate of acid trehalase
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-
?
alpha,alpha-trehalose + H2O
2 D-glucose
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the acid trehalase is involved in catabolism of trehalose by export of the disaccharide, extracellular hydrolysis, and subsequent uptake of released D-glucose
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-
?
alpha,alpha-trehalose + H2O
2 D-glucose
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trehalose is one of the major storage carbohydrates in the yeast Saccharomyces cerevisiae
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-
?
alpha,alpha-trehalose + H2O
2 D-glucose
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spores contain neutral and acid trehalase. Lack of neutral trehalase severely reduces spore germination in fission yeast and sporulation-specific acid trehalase somehow participates in the degradation of endogenous trehalose in the ansence of neutral trehalase, thus playing an ancillary role during germination
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-
?
alpha,alpha-trehalose + H2O
2 D-glucose
-
the enzyme is important in insect metabolism with trehalose being the main circulating sugar in the organism with functions in storage, fuel for flight, and as a cryoprotector, in hemolymph trehalose is important for carbohydrate intake and nutritional homeostasis, enzyme deficiency leads to severe metabolic problems
-
-
?
alpha,alpha-trehalose + H2O
2 D-glucose
-
the enzyme is important in insect metabolism with trehalose being the main circulating sugar in the organism with functions in storage, fuel for flight, and as a cryoprotector, in hemolymph trehalose is important for carbohydrate intake and nutritional homeostasis, enzyme deficiency leads to severe metabolic problems
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-
?
alpha,alpha-trehalose + H2O
alpha-D-glucopyranose + D-glucose
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highly specific for
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?
alpha,alpha-trehalose + H2O
alpha-D-glucopyranose + D-glucose
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inverting-type enzyme
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?
alpha,alpha-trehalose + H2O
alpha-D-glucopyranose + D-glucose
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may play a role in the regulating the carbohydrate allocation in plants
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?
alpha,alpha-trehalose + H2O
alpha-D-glucopyranose + D-glucose
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?
alpha,alpha-trehalose + H2O
alpha-D-glucopyranose + D-glucose
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-
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?
alpha,alpha-trehalose + H2O
alpha-D-glucopyranose + D-glucose
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-
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?
alpha,alpha-trehalose + H2O
alpha-D-glucopyranose + D-glucose
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-
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?
alpha,alpha-trehalose + H2O
alpha-D-glucopyranose + D-glucose
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-
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?
alpha,alpha-trehalose + H2O
alpha-D-glucopyranose + D-glucose
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?
alpha,alpha-trehalose + H2O
alpha-D-glucopyranose + D-glucose
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neutral trehalase mobilizes trehalose accumulated by fungal cells as a protective and storage carbohydrate
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?
alpha,alpha-trehalose + H2O
alpha-D-glucose + beta-D-glucose
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the enzyme, an anomer-inverting glycosylase, hydrolyzes alpha,alpha-trehalase to equimolar amounts of alpha- and beta-D-glucose. It is also capable of synthesizing trehalose from D-glucose in the reverse reaction
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r
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
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?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
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?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
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-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
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-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
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-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
hydrolysis of exogenous trehalose
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?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
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-
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?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
hydrolysis of exogenous trehalose
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?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
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-
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?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
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-
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?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
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-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
A4WBE4
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
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-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
A4WBE4
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
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-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
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-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
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-
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?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
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-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
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-
-
-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
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-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
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-
-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
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-
-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
trehalase is an indispensable component of insect hemolymph that plays important role in energy metabolism and stress resistance
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-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
-
trehalase is an indispensable component of insect hemolymph that plays important role in energy metabolism and stress resistance
-
-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
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-
-
?
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
-
-
?