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Literature summary for 3.2.1.28 extracted from

  • Cipolla, L.; Sgambato, A.; Forcella, M.; Fusi, P.; Parenti, P.; Cardona, F.; Bini, D.
    N-Bridged 1-deoxynojirimycin dimers as selective insect trehalase inhibitors (2014), Carbohydr. Res., 389, 46-49.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,2-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)ethane-1,2-dione micromolar inhibitor Chironomus riparius
1,2-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)ethane-1,2-dione micromolar inhibitor Sus scrofa
1,3-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)propane-1,3-dione micromolar inhibitor Chironomus riparius
1,4-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)butane-1,4-dione micromolar inhibitor Chironomus riparius
1,4-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)butane-1,4-dione micromolar inhibitor Sus scrofa
1-deoxynojirimycin
-
Chironomus riparius
1-deoxynojirimycin
-
Sus scrofa
casuarine-6-O-alpha-D-glucoside
-
Chironomus riparius
casuarine-6-O-alpha-D-glucoside
-
Sus scrofa
additional information not inhibited by 1,3-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)propane-1,3-dione Sus scrofa
trehazolin
-
Chironomus riparius
trehazolin
-
Sus scrofa
validoxylamine A
-
Chironomus riparius
validoxylamine A
-
Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha,alpha-trehalose + H2O Sus scrofa
-
beta-D-glucose + alpha-D-glucose
-
?
alpha,alpha-trehalose + H2O Chironomus riparius
-
beta-D-glucose + alpha-D-glucose
-
?

Organism

Organism UniProt Comment Textmining
Chironomus riparius J7EJ73
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
larva
-
Chironomus riparius
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha,alpha-trehalose + H2O
-
Sus scrofa beta-D-glucose + alpha-D-glucose
-
?
alpha,alpha-trehalose + H2O
-
Chironomus riparius beta-D-glucose + alpha-D-glucose
-
?

Synonyms

Synonyms Comment Organism
alpha-glucoside-1-glucohydrolase
-
Sus scrofa
alpha-glucoside-1-glucohydrolase
-
Chironomus riparius
trehalase
-
Sus scrofa
trehalase
-
Chironomus riparius

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00283
-
at pH 6.9 and 30°C Chironomus riparius 1-deoxynojirimycin
0.00596
-
at pH 6.9 and 30°C Sus scrofa 1-deoxynojirimycin
0.0061
-
at pH 6.9 and 30°C Chironomus riparius 1,2-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)ethane-1,2-dione
0.011
-
at pH 6.9 and 30°C Chironomus riparius 1,4-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)butane-1,4-dione
0.024
-
at pH 6.9 and 30°C Sus scrofa 1,2-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)ethane-1,2-dione
0.076
-
at pH 6.9 and 30°C Sus scrofa 1,4-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)butane-1,4-dione
0.223
-
at pH 6.9 and 30°C Chironomus riparius 1,3-bis((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)propane-1,3-dione