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Literature summary for 3.2.1.28 extracted from

  • Maicas, S.; Guirao-Abad, J.; Argüelles, J.
    Yeast trehalases Two enzymes, one catalytic mission (2016), Biochim. Biophys. Acta, 1860, 2249-2254 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
glucose the enzyme is regulated by glucose-induced catabolite repression Candida albicans
Mg2+
-
Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Saccharomyces cerevisiae 5829
-
vacuole
-
Candida albicans 5773
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates Saccharomyces cerevisiae
Mn2+ activates Saccharomyces cerevisiae
additional information the activity is independent of divalent cations Candida albicans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
104000
-
calculated from sequence Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha,alpha-trehalose + H2O Candida albicans hydrolysis of exogenous trehalose beta-D-glucose + alpha-D-glucose
-
?
alpha,alpha-trehalose + H2O Saccharomyces cerevisiae hydrolysis of intracellular trehalose in response to physiological stimuli beta-D-glucose + alpha-D-glucose
-
?
alpha,alpha-trehalose + H2O Candida albicans ATCC MYA-2876 hydrolysis of exogenous trehalose beta-D-glucose + alpha-D-glucose
-
?
alpha,alpha-trehalose + H2O Saccharomyces cerevisiae ATCC 204508 hydrolysis of intracellular trehalose in response to physiological stimuli beta-D-glucose + alpha-D-glucose
-
?

Organism

Organism UniProt Comment Textmining
Candida albicans Q5AAU5
-
-
Candida albicans ATCC MYA-2876 Q5AAU5
-
-
Saccharomyces cerevisiae P32356
-
-
Saccharomyces cerevisiae ATCC 204508 P32356
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is regulated by reversible phosphorylation mediated by the cAMP-PKA pathway Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha,alpha-trehalose + H2O
-
Saccharomyces cerevisiae beta-D-glucose + alpha-D-glucose
-
?
alpha,alpha-trehalose + H2O
-
Candida albicans beta-D-glucose + alpha-D-glucose
-
?
alpha,alpha-trehalose + H2O hydrolysis of exogenous trehalose Candida albicans beta-D-glucose + alpha-D-glucose
-
?
alpha,alpha-trehalose + H2O hydrolysis of intracellular trehalose in response to physiological stimuli Saccharomyces cerevisiae beta-D-glucose + alpha-D-glucose
-
?
alpha,alpha-trehalose + H2O
-
Candida albicans ATCC MYA-2876 beta-D-glucose + alpha-D-glucose
-
?
alpha,alpha-trehalose + H2O hydrolysis of exogenous trehalose Candida albicans ATCC MYA-2876 beta-D-glucose + alpha-D-glucose
-
?
alpha,alpha-trehalose + H2O
-
Saccharomyces cerevisiae ATCC 204508 beta-D-glucose + alpha-D-glucose
-
?
alpha,alpha-trehalose + H2O hydrolysis of intracellular trehalose in response to physiological stimuli Saccharomyces cerevisiae ATCC 204508 beta-D-glucose + alpha-D-glucose
-
?

Synonyms

Synonyms Comment Organism
acid trehalase
-
Candida albicans
ATC1
-
Candida albicans
neutral trehalase
-
Saccharomyces cerevisiae
NTH1
-
Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
Saccharomyces cerevisiae
40
-
-
Candida albicans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5 5
-
Candida albicans
6.8 7
-
Saccharomyces cerevisiae