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Information on EC 2.7.7.9 - UTP-glucose-1-phosphate uridylyltransferase
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EC Tree
2.7.7.9 UTP-glucose-1-phosphate uridylyltransferaseSpecify your search results
Word Map
- 2.7.7.9
- phosphoglucomutase
- glycogen
- udp-galactose
- adp-glucose
- dictyostelium
- exopolysaccharide
- udp-sugars
- udp-n-acetylglucosamine
- galactose-1-phosphate
-
udp-glucuronic
- galactokinase
-
pyrophosphorolysis
-
aureobasidium
-
sucrose-phosphate
-
leloir
- uridyltransferase
- xylinum
- gellan
- agriculture
- synthesis
- medicine
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
All3274, CugP, cyanobacterial UDP-Glc PPase, ExoN, GalU, Glc-1-P UTase, GlcNAc-1-P UTase, glucose 1-phosphate uridylyltransferase, glucose-1-phosphate uridylyltransferase, plastid UDP-glucose pyrophosphorylase, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ExoN
Glc-1-P UTase
glucose 1-phosphate uridylyltransferase
-
-
-
-
glucose-1-phosphate uridylyltransferase
plastid UDP-glucose pyrophosphorylase
ST0452
UDP glucose pyrophosphorylase
-
-
-
-
UDP-Glc pyrophosphorylase
UDP-glucose pyrophosphorylase
UDP-glucose pyrophosphorylase 1
UDPG phosphorylase
-
-
-
-
UDPG pyrophosphorylase
-
-
-
-
UDPG-pyrophosphorylase
UDPglucose pyrophosphorylase
UGP
UGP1
UGP3
UgpA
UGPase
uridine 5'-diphosphoglucose pyrophosphorylase
-
-
-
-
uridine diphosphate-D-glucose pyrophosphorylase
-
-
-
-
uridine diphosphate-glucose pyrophosphorylase
uridine diphosphoglucose pyrophosphorylase
-
-
-
-
uridine-diphosphate glucose pyrophosphorylase
-
-
-
-
uridylyltransferase, glucose 1-phosphate
-
-
-
-
VldB
glucose-1-phosphate uridylyltransferase
-
-
-
-
UDP-glucose pyrophosphorylase
-
-
-
-
UDPglucose pyrophosphorylase
-
-
-
-
uridine diphosphate-glucose pyrophosphorylase
Q8GQP9
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
sequential ordered bi bi reaction mechanism
-
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
sequential ordered bi bi reaction mechanism
-
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
mechanism
-
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
mechanism
-
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
mechanism
-
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
mechanism
-
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
mechanism
-
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
mechanism
-
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
Trp333 and Arg391 are essential for activity, while His266, Arg389, Arg422, Arg 445, and Trp218 are not
-
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
sequential ordered bi bi reaction mechanism
-
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
ordered bi-bi mechanism. The molecular geometry at position 4 of glucose is responsible for substrate specificity. The gamma-phosphate group of UTP is essential for binding and for induction of the open conformation, which then allows entry of glucose 1-phosphate
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
ordered sequential Bi Bi mechanism, overview. Pyrimidine bases may approach the base binding site, but they cannot form the tight interactions observed in the HpUGPase/UDP-Glc complex. Thymine binding would be hindered by its extra methyl group, and cytosine could not make specific hydrogen bonds
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
UTP:alpha-D-glucose-1-phosphate uridylyltransferase
-
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CAS REGISTRY NUMBER
COMMENTARY
9026-22-6
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + alpha-D-glucose 1-phosphate
diphosphate + ADP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
ATP + alpha-D-glucose 1-phosphate
diphosphate + ADP-glucose
-
13.7% of the activity with UTP
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
farnesyl triphosphate + UDP-glucose
farnesyl-tetraphosphouridine + alpha-D-glucose + diphosphate
-
-
-
-
?
geranyl triphosphate + UDP-glucose
geranyl-tetraphosphouridine + alpha-D-glucose + diphosphate
-
-
-
-
?
GTP + alpha-D-glucose 1-phosphate
diphosphate + GDP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
isopentenyl triphosphate + UDP-glucose
isopentenyl-tetraphosphouridine + alpha-D-glucose + diphosphate
-
-
-
-
?
methylenebisphosphonate + UDP-glucose
uridine 5'-(beta,gamma-methylenetriphosphate) + alpha-D-glucose + diphosphate
-
-
-
-
?
monothiodiphosphate + UDP-glucose
UTPbeta,gammaS + alpha-D-glucose 1-phosphate
-
poor substrate, 4.8% of Vmax with diphosphate
UTPbeta,gammaS is chemically unstable and undergoes hydrolysis to UDPbetaS and phosphate, which renders the otherwise reversible reaction irreversible, t1/2 at 25°C: 0.5 min
ir
UDP-glucose + adenosine 5'-tetraphosphate
D-glucose-1-phosphate + adenosyl-5'-pentaphospho-5'-uridine
-
-
-
-
?
UDP-glucose + ATP
D-glucose-1-phosphate + adenosyl-5'-tetraphospho-5'-uridine
-
-
-
-
?
UDP-glucose + CTP
D-glucose-1-phosphate + cytidinyl-5'-tetraphospho-5'-uridine
-
-
-
-
?
UDP-glucose + GTP
D-glucose-1-phosphate + guanosyl-5'-tetraphospho-5'-uridine
-
-
-
-
?
UDP-glucose + guanosine 5'-tetraphosphate
D-glucose-1-phosphate + guanosyl-5'-pentaphospho-5'-uridine
-
-
-
-
?
UDP-glucose + tetrapolyphosphate
uridine-5'-pentaphosphate + D-glucose-1-phosphate
-
-
-
-
?
UDP-glucose + tripolyphosphate
uridine-5'-tetraphosphate + D-glucose-1-phosphate
-
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
UTP + alpha-D-glucose 1-phosphate
Q8YS18
enzyme is highly specific for both UTP and glucose 1-phosphate
-
-
r
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
no activity
-
-
-
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
calf and human liver, poor substrate
-
r
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
calf and human liver, poor substrate
-
r
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
very low activity, wild-type and mutant W218
-
r
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
18.5% of the activity with UTP
-
r
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
-
no activity
-
-
-
diphosphate + GDP-glucose
GTP + alpha-D-glucose 1-phosphate
-
no activity
-
-
-
diphosphate + GDP-glucose
GTP + alpha-D-glucose 1-phosphate
-
calf and human liver, poor substrate
-
-
r
diphosphate + GDP-glucose
GTP + alpha-D-glucose 1-phosphate
-
calf and human liver, poor substrate
-
-
r
diphosphate + GDP-glucose
GTP + alpha-D-glucose 1-phosphate
-
14.3% of the activity with UTP
-
r
diphosphate + GDP-glucose
GTP + alpha-D-glucose 1-phosphate
-
no activity
-
-
-
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
no activity
-
-
-
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
calf and human liver
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
calf and human liver
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
very low activity, wild-type and mutant W218
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + TDP-glucose
TTP + alpha-D-glucose 1-phosphate
-
poor substrate
-
r
diphosphate + UDP-glucose
UTP + alpha-D-glucose 1-phosphate
-
-
-
?
diphosphate + UDP-glucose
UTP + alpha-D-glucose 1-phosphate
-
-
-
?
diphosphate + UDP-mannose
UTP + D-mannose 1-phosphate
-
calf and human liver, poor substrate
-
-
r
diphosphate + UDP-mannose
UTP + D-mannose 1-phosphate
-
calf and human liver, poor substrate
-
-
r
diphosphate + UDP-xylose
UTP + D-xylose 1-phosphate
-
reaction at 10% the rate of UDP-glucose or UDP-galactose pyrophosphorolysis
-
-
r
diphosphate + UDP-xylose
UTP + D-xylose 1-phosphate
-
poor substrate
-
-
r
diphosphate + UDP-xylose
UTP + D-xylose 1-phosphate
-
calf and human liver
-
-
r
diphosphate + UDP-xylose
UTP + D-xylose 1-phosphate
-
poor substrate
-
-
r
diphosphate + UDP-xylose
UTP + D-xylose 1-phosphate
-
calf and human liver
-
-
r
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
TTP + alpha-D-glucose 1-phosphate
diphosphate + alpha-TDP-glucose
-
-
-
?
TTP + alpha-D-glucose 1-phosphate
diphosphate + alpha-TDP-glucose
-
-
-
?
TTP + alpha-D-glucose 1-phosphate
TDP-glucose + diphosphate
Q4UVD0
-
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + alpha-UDP-galactose
-
-
-
?
UTP + alpha-D-galactose 1-phosphate
diphosphate + alpha-UDP-galactose
-
-
-
?
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-alpha-D-galactose
M4M6L5
-
-
-
?
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-alpha-D-galactose
M4M6L5
-
-
-
?
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
at the same rate as UDP-glucose
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
about 15% of the activity with UDP-glucose
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
reverse reaction: calf and human liver
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
no activity
-
-
-
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
reaction at 5% the rate of UDP-glucose synthesis
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
reverse reaction: calf and human liver
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
1-12% of the activity with UDP-glucose
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
low activity
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
no activity
-
-
-
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
equilibrium dialysis: 8 mol UDP-galactose bound per mol enzyme
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
3.5% of the activity with UDP-glucose
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
-
r
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-galactose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
M4M6L5
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
M4M6L5
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
UGP-1 is specifically active toward UTP with alpha-D-glucose 1-phosphate, but displays very low or no activity toward other nucleotides, with either alpha-D-glucose 1-phosphate or alpha-D-mannose 1-phosphate
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
enzyme is highly specific for UTP and glucose 1-phosphate
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
highly specific for UTP
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reverse reaction: highly specific for UDP-glucose
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is induced during amoeba encystment
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
highly specific for UTP
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reverse reaction: highly specific for UDP-glucose
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is induced during amoeba encystment
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
Acetabularia sp.
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reaction at the same rate as UDP-galactose
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
specific for alpha-D-glucose 1-phosphate
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
central reaction in galactose and trehalose metabolism
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
the soluble enzyme shows an apparent higher affinity for and a 2fold higher activity with alpha-D-glucose 1-phosphate than UTP
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reaction critical to mono- and polysaccharide biosynthesis
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
specific for alpha-D-glucose 1-phosphate
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
highly specific for UTP
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
key enzyme in biosynthesis of sucrose, cellulose, and other saccharides
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
cumulative feedback regulation in vivo, modulates the flow of carbon into pathways leading to cell wall polysaccharide synthesis
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
specific for alpha-D-glucose 1-phosphate
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
equilibrium dialysis: 8 mol UDP-glucose bound per mol enzyme
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reverse reaction: highly specific for UDP-glucose
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
highly specific for UTP
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is essential for cell viability
-
-
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
Saccharomyces fragilis
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
highly specific for UTP
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reverse reaction: highly specific for UDP-glucose
specific for UDP-glucose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
Q8GQP8
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is specific for UTP
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is specific for UTP
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
involved in exopolysaccharide biosynthesis
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
involved in exopolysaccharide biosynthesis
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
the multifunctional enzyme also shows activity with UTP + alpha-D-glucose 1-phosphate (EC 2.7.7.24, glucose-1-phosphate thymidylyltransferase), UTP + N-acetylglucosamine 1-phosphate (EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase), dTTP + N-acetylglucosamine 1-phosphate (N-acetylglucosamine 1-phosphate thymidylyltransferase), dCTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate cytidylyltransferase), dGTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate guanylyltransferase), dATP + alpha-D-glucose 1-phosphate (glucose-1-phosphate adenylyltransferase). No activity with: alpha-D-glucose 1-phosphate + dATP, alpha-D-glucose 1-phosphate + dCTP, alpha-D-glucose 1-phosphate + dGTP, UTP + alpha-D-mannose1-phosphate, UTP + alpha-D-galactose 1-phosphate, UTP + alpha-D-glucosamine 1-phosphate
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
the multifunctional enzyme also shows activity with UTP + alpha-D-glucose 1-phosphate (EC 2.7.7.24, glucose-1-phosphate thymidylyltransferase), UTP + N-acetylglucosamine 1-phosphate (EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase), dTTP + N-acetylglucosamine 1-phosphate (N-acetylglucosamine 1-phosphate thymidylyltransferase), dCTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate cytidylyltransferase), dGTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate guanylyltransferase), dATP + alpha-D-glucose 1-phosphate (glucose-1-phosphate adenylyltransferase). No activity with: alpha-D-glucose 1-phosphate + dATP, alpha-D-glucose 1-phosphate + dCTP, alpha-D-glucose 1-phosphate + dGTP, UTP + alpha-D-mannose1-phosphate, UTP + alpha-D-galactose 1-phosphate, UTP + alpha-D-glucosamine 1-phosphate
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
UDP-glucose + diphosphate
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
UDP-glucose + diphosphate
-
14.2% activity with galactose-1-phosphate
-
-
?
UTP + alpha-D-glucose 1-phosphate
UDP-glucose + diphosphate
Q4UVD0
in the presence of a divalent metal cation (mainly Mg2+)
-
-
r
UTP + alpha-D-glucose 1-phosphate
UDP-glucose + diphosphate
in the presence of a divalent metal cation (mainly Mg2+)
-
-
r
additional information
?
-
-
no activity with ATP, CTP, and GTP
-
-
-
additional information
?
-
-
no activity with ADP-glucose
-
-
-
additional information
?
-
-
no activity with ATP, CTP, and GTP
-
-
-
additional information
?
-
-
UDP-glucose and UDP-galactose pyrophosphorolysis activity in Bifidobacterium bifidum are catalyzed by a single enzyme protein
-
-
-
additional information
?
-
-
UDP-glucose and UDP-galactose pyrophosphorolysis activity in Bifidobacterium bifidum are catalyzed by a single enzyme protein
-
-
-
additional information
?
-
M4M6L5
the activity of UgpA toward glucose 1-phosphate is about 33fold higher than that toward galactose 1-phosphate
-
-
-
additional information
?
-
M4M6L5
the activity of UgpA toward glucose 1-phosphate is about 33fold higher than that toward galactose 1-phosphate
-
-
-
additional information
?
-
Q19TV8
no substrate: alpha-D-glalctose 1-phosphate
-
-
-
additional information
?
-
-
involved in synthesis of hemagglutinin, sulfated proteoglycans, and glycogen in cartilage
-
-
-
additional information
?
-
no substrates: ATP, GTP, nor CTP
-
-
-
additional information
?
-
no substrates: ATP, GTP, nor CTP
-
-
-
additional information
?
-
-
the enzyme catalyses a freely reversible reaction and is specific for alpha-D-glucose 1-phosphate
-
-
-
additional information
?
-
-
molecular geometry at position 4 of glucose is responsible for substrate specificity. The gamma-phosphate group of UTP is essential for binding and for induction of the open conformation, which then allows entry of glucose 1-phosphate
-
-
-
additional information
?
-
molecular geometry at position 4 of glucose is responsible for substrate specificity. The gamma-phosphate group of UTP is essential for binding and for induction of the open conformation, which then allows entry of glucose 1-phosphate
-
-
-
additional information
?
-
isoform Ugp1 is required for callose deposition during pollen mother cell meiosis and bridges the apoplastic unloading pathway and pollen development
-
-
-
additional information
?
-
-
no utilization of the nucleotide diphosphate sugars UDP-Gal, UDP-GlnA, UDP-Man, UDP-Xyl, ADP-Glc, CDP-Glc and TDP-Glc
-
-
-
additional information
?
-
-
UDP-galactose is not a UMP-donor and ADP not a UMP-acceptor
-
-
-
additional information
?
-
-
the bisphosphonates alendronate, pamidronate, clodronate and etidronate are not acceptors of UMP. But UDP-glucose serves as uridylyl donor to triphosphate derivatives of the mevalonate pathway, farnesyl triphosphate, geranyl triphosphate, and isopentenyl triphosphate, with formation of farnesyl-tetraphosphouridine, geranyl-tetraphosphouridine, and isopentenyl-tetraphosphouridine, overview. No activity with farnesyl-, geranyl-, or isopentenyl-diphosphates or with dimethylallyl pyrophosphate
-
-
-
additional information
?
-
no substrates: dTTP, CTP, ATP, and GTP, Glc-1P, GlcNAc-1P, Gal-1P, and Man-1P
-
-
-
additional information
?
-
-
no substrates: dTTP, CTP, ATP, and GTP, Glc-1P, GlcNAc-1P, Gal-1P, and Man-1P
-
-
-
additional information
?
-
the enzyme is specific for alpha-D-glucose 1-phosphate, no activity with N-acetylgalactosamine 1-phosphate, N-acetylglucosamine 1-phosphate, or galactosamine 1-phosphate
-
-
-
additional information
?
-
-
the enzyme is specific for alpha-D-glucose 1-phosphate, no activity with N-acetylgalactosamine 1-phosphate, N-acetylglucosamine 1-phosphate, or galactosamine 1-phosphate
-
-
-
additional information
?
-
the enzyme is specific for alpha-D-glucose 1-phosphate, no activity with N-acetylgalactosamine 1-phosphate, N-acetylglucosamine 1-phosphate, or galactosamine 1-phosphate
-
-
-
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
Q18910
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
Q18910
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is induced during amoeba encystment
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is induced during amoeba encystment
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
Acetabularia sp.
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
Q9XUS5
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
A5XCL5
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
central reaction in galactose and trehalose metabolism
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
reaction critical to mono- and polysaccharide biosynthesis
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
O25363
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
Q43772
key enzyme in biosynthesis of sucrose, cellulose, and other saccharides
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
cumulative feedback regulation in vivo, modulates the flow of carbon into pathways leading to cell wall polysaccharide synthesis
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
C7GP37
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
enzyme is essential for cell viability
-
-
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
Q8GQP8
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
involved in exopolysaccharide biosynthesis
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
involved in exopolysaccharide biosynthesis
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
D3HTY9
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
D3HTY9
-
-
-
r
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
-
-
activation of glucosyl residues for glycogen synthesis, participates in synthesis of numerous compounds including cell wall polymers in higher plants and microorganisms, starch, trehalose, glycosides, glycolipids, heparin, microbial antigens, lactose, glucuronides, and rhamnose
r
additional information
?
-
-
involved in synthesis of hemagglutinin, sulfated proteoglycans, and glycogen in cartilage
-
-
-
additional information
?
-
A3QQQ3
isoform Ugp1 is required for callose deposition during pollen mother cell meiosis and bridges the apoplastic unloading pathway and pollen development
-
-
-
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Co2+
Magnesium
Q6M6R3
crystallization data, two magnesium ions coordinate to UDP-glucose. Magnesium is involved in catalytic mechanism
Mg2+
Mn2+
Ni2+
additional information
Co2+
-
activation; no effect on liver enzyme form I, 2fold activation of enzyme form from sublingual gland, inhibition of enzyme form from submandibular gland
Co2+
-
about 25% as effective as Mg2+
Mg2+
-
Mg-diphosphate is the actual substrate; MgUTP is the actual substrate; requirement
Mg2+
the Mg2+ ion coordinated by Asp130, two oxygen atoms of phosphoryl groups, and three water molecules with octahedral geometry. The Mg2+ ion plays a key role in the enzymatic activity of UGPase by enhancing the binding of UGPase to UTP or UDP-glucose
Mg2+
-
Mg-diphosphate is the actual substrate; MgUTP is the actual substrate; requirement
Mg2+
-
increasing MgSO4 concentrations shift the apparent equilibrium toward UDP-glucose synthesis; Mg-diphosphate is the actual substrate; requirement
Mn2+
-
about 25% as effective as Mg2+; activation
Mn2+
-
about 25% as effective as Mg2+; activation; UDP-glucose synthesis: Mn2+ in excess of diphosphate-concentration inhibits
Ni2+
-
about 25% as effective as Mg2+
additional information
the enzyme is divalent cation-dependent, no activation by Zn2+ and Cu2+
additional information
-
the enzyme is divalent cation-dependent, no activation by Zn2+ and Cu2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
H2O2
complete loss of activity after 30 min, inactivation is reverted by reduction by cysteine and thioredoxin
iodoacetamide
-
wild-type: loss of 56% activity after 30 min at 0.1 mM, mutant C123S is not affected
NAD+
Q8YS18
presence of either NAD or NADP results in a decrease of activity to about 80% or 50%, respectively
NADP+
Q8YS18
presence of either NAD or NADP results in a decrease of activity to about 80% or 50%, respectively
sodium nitroprusside
complete loss of activity after 30 min, inactivation is reverted by reduction by cysteine and thioredoxin
Co2+
-
no effect on liver enzyme form I, 2fold activation of enzyme form from sublingual gland, inhibition of enzyme form from submandibular gland
Co2+
-
in excess of diphosphate-concentration, activates at lower concentrations
diphosphate
-
with 0.25 mM 57% activity, with 1 mM 11% activity, with 10 mM 1.5% activity
diphosphate
-
possible alternate regulatory mechanism; product inhibition
Mn2+
-
in excess of diphosphate-concentration, activates at lower concentrations
UDP-glucose
-
UDP-galactose pyrophosphorolysis or UDP-glucose synthesis
UDP-glucose
-
competitive to UTP, noncompetitive to glucose 1-phosphate
additional information
-
no effect of PCMB, iodoacetate, 2-mercaptoethanol or DTT
-
additional information
-
inhibition kinetics for UDP-sugars; little or no inhibition by alpha-D-mannose 1-phosphate, alpha-D-xylose 1-phosphate or alpha-D-glucuronic acid 1-phosphate
-
additional information
Q8YS18
not inhibitory: 1 mM 2-oxoglutaric acid, 3-phosphoglyceric acid, and 5-aminolevulinic acid
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Co2+
-
no effect on liver enzyme form I, 2fold activation of enzyme form from sublingual gland, inhibition of enzyme form from submandibular gland
additional information
-
enzyme expression is inducible by exogenous sucrose, light and cold stress
-
additional information
-
no effect of PCMB, iodoacetate, 2-mercaptoethanol or DTT
-
additional information
-
rat mammary gland enzyme seems to undergo structural changes that lead to a more active form
-
additional information
-
no activation by 3-phosphoglycerate; no activation by fructose 2,6-bisphosphate, UDPglucose synthesis
-
additional information
-
no activation by 3-phosphoglycerate; no activation by fructose 1,6-bisphosphate, fructose 6-phosphate, phosphoenolpyruvate or p-hydroxymandelonitrile-beta-D-glucopyranoside
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
6-phosphofructokinase deficiency
Activities of glycogen synthetase and UDPG-pyrophosphorylase in muscle of a patient with a new type of muscle glycogenosis caused by phosphofructokinase deficiency.
Carcinoma
UDPglucose pyrophosphorylase from Ehrlich ascites carcinoma cell--purification and characterization.
Diabetes Mellitus
Hexose metabolism in pancreatic islets UDP-glucose pyrophosphorylase activity.
Diabetes Mellitus, Experimental
[UDPG pyrophosphorylase and phosphoglucomutase activity in the liver of rats with alloxan diabetes]
Food Hypersensitivity
Identification of latex UDP glucose pyrophosphorylase (Hev b UDPGP) as a novel cause of latex fruit allergy syndrome.
Galactosemias
UDP-galactose pyrophosphorylase in mice with galactose-1-phosphate uridyltransferase deficiency.
Glycogen Storage Disease
Activities of glycogen synthetase and UDPG-pyrophosphorylase in muscle of a patient with a new type of muscle glycogenosis caused by phosphofructokinase deficiency.
Hypersensitivity
Identification of latex UDP glucose pyrophosphorylase (Hev b UDPGP) as a novel cause of latex fruit allergy syndrome.
Infertility, Male
Genes associated with thermosensitive genic male sterility in rice identified by comparative expression profiling.
Infertility, Male
Relationship between male sterility and ?-1,3-glucanase activity and callose deposition-related gene expression in wheat (Triticum aestivum L.).
Neoplasms
Role of nuclear glycogen synthase and cytoplasmic UDP glucose pyrophosphorylase in the biosynthesis of nuclear glycogen in HD33 Ehrlich-Lettré ascites tumor cells.
Plague
Crystal structure of UDP-glucose pyrophosphorylase from Yersinia pestis, a potential therapeutic target against plague.
Starvation
Integrated analysis of transcriptome and metabolites reveals an essential role of metabolic flux in starch accumulation under nitrogen starvation in duckweed.
Tuberculosis
Allosteric regulation of the partitioning of glucose-1-phosphate between glycogen and trehalose biosynthesis in Mycobacterium tuberculosis.
Tuberculosis
Expression, purification, and characterization of a functionally active Mycobacterium tuberculosis UDP-glucose pyrophosphorylase.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.09
alpha-D-galactose 1-phosphate
cosubstrate UTP, S0.5 value, hyperbolic behaviour, pH 8.0, 37°C
10
alpha-D-galactose 1-phosphate
-
pH 7.5, temperature not specified in the publication
0.031
alpha-D-glucose 1-phosphate
pH 7.5, temperature not specified in the publication
0.03224
alpha-D-glucose 1-phosphate
cosubstrate: UTP, pH 7.5, 25°C
0.033
alpha-D-glucose 1-phosphate
-
pH 7.5, temperature not specified in the publication
0.04988
alpha-D-glucose 1-phosphate
cosubstrate: dTTP, pH 7.5, 25°C
0.055 - 0.08
alpha-D-glucose 1-phosphate
-
at physiological substrate concentration, pH 8.5, 37°C
0.07765
alpha-D-glucose 1-phosphate
cosubstrate: UTP, pH 7.5, 25°C
0.122
alpha-D-glucose 1-phosphate
pH 7.2, temperature not specified in the publication, recombinant enzyme
0.13
alpha-D-glucose 1-phosphate
cosubstrate UTP, S0.5 value, hyperbolic behaviour, pH 8.0, 37°C
0.198
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant mutant N491P/L492E
0.202
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant mutant P414G/T415P
0.219
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant mutant T406K/M407L
0.235
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant mutant S309N/S311R
0.316
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant enzyme
0.36
alpha-D-glucose 1-phosphate
cosubstrate TTP, S0.5 value, hyperbolic behaviour, pH 8.0, 37°C
0.68 - 1
alpha-D-glucose 1-phosphate
-
at substrate concentrations above 2 mM, pH 8.5, 37°C
0.68 - 1
alpha-D-glucose 1-phosphate
-
recombinant wild-type enzyme, pH 8.0, 25°C
0.83
alpha-D-glucose 1-phosphate
pH 7.5, 37°C, recombinant enzyme
2.5 - 3
alpha-D-glucose 1-phosphate
-
mutant enzyme Y97N, pH 7.5, 80°C
0.11 - 0.13
diphosphate
-
at physiological substrate concentration, pH 8.5, 37°C
0.00167
UDP-glucose
pH 7.5, temperature not specified in the publication
0.00433
UDP-glucose
pH 7.5, temperature not specified in the publication
0.03
UDP-glucose
-
Ccut-8 mutant protein; K183A mutant protein; K332A mutant protein
0.12 - 0.18
UDP-glucose
-
at physiological substrate concentrations, pH 8.5, 37°C
0.774
UDP-glucose
pH 7.5, temperature not specified in the publication
0.053
UTP
pH 7.2, temperature not specified in the publication, recombinant enzyme
0.08
UTP
cosubstrate alpha-D-galactose 1-phosphate, S0.5 value, hyperbolic behaviour, pH 8.0, 37°C
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
-
kinetic parameters of various organisms, pH 8.0, overview
-
additional information
additional information
Michaelis-Menten kinetics, overview
-
additional information
additional information
-
Michaelis-Menten kinetics, overview
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
22.96
alpha-D-glucose 1-phosphate
cosubstrate: UTP, pH 7.5, 25°C
23.24
alpha-D-glucose 1-phosphate
cosubstrate: UTP, pH 7.5, 25°C
23.58
alpha-D-glucose 1-phosphate
cosubstrate: dTTP, pH 7.5, 25°C
33.11
alpha-D-glucose 1-phosphate
pH 7.5, temperature not specified in the publication
0.21
UDP-glucose
pH 7.5, temperature not specified in the publication
19.98
UDP-glucose
pH 7.5, temperature not specified in the publication
19.98
UDP-glucose
pH 7.5, temperature not specified in the publication
additional information
additional information
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
470
alpha-D-glucose 1-phosphate
cosubstrate: dTTP, pH 7.5, 25°C
1067
alpha-D-glucose 1-phosphate
pH 7.5, temperature not specified in the publication
273
UDP-glucose
pH 7.5, temperature not specified in the publication
4610
UDP-glucose
pH 7.5, temperature not specified in the publication
11980
UDP-glucose
pH 7.5, temperature not specified in the publication
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
-
simple additive inhibition of inhibitors at low individual concentrations and low substrate concentrations
-
additional information
additional information
Acetabularia sp.
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
additional information
additional information
-
inhibition constants of various organisms
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.11 - 0.22
-
activity in cell extracts of cells grown on different sugar sources
2
-
pH 7.5, 80°C, mutant enzyme DC05 (deletion of the C-terminal 5 residues of the ST0452 protein)
2.6
-
pH 7.5, 80°C, mutant enzyme DC011 (deletion of the C-terminal 11 residues of the ST0452 protein)
200
additional information
additional information
-
the UGPase protein content and enzyme activity in the Pi-deficient mutant is about twice as high as in wild type and Pi-excess mutants, regardless of the light/dark conditions
additional information
-
similar activities of the wild-type UGPase in Tris, Hepes or Mops buffers. Half of the activity in 100 mM sodium phosphate. Compared with the wild-type UGPase the mutants KK127-128LL, C99S and LIV135-137NIN display reduced activities in all buffers.
additional information
-
2-3 fold higher activity in transgenic tibialis anterior, extensor digitorum longus and gastrocnemius muscles than in wild type. Very little increase in activity in transgenic soleus muscle. Transgenes PPL-1 and PPL-2
additional information
Q8YS18
as the enzyme concentration increases from 0.0125 mM to 0.6 mM, the specific activity also increases 4fold within this range and is constant at higher concentrations
additional information
-
Vmax isoenzyme RmlA 37.05, 30°C, pH 7.8; Vmax isoenzyme UgpG 1.28, 30°C, pH 7.8
additional information
-
activity of UDPGP is significantly up-regulated in muscle tissues from RN- mutants
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6 - 7.5
6.5 - 8
7.3 - 8.6