Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli BL21 (DE3) | Streptococcus pneumoniae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Abacavir | - |
Streptococcus pneumoniae | |
capecitabine | - |
Streptococcus pneumoniae | |
decitabine | - |
Streptococcus pneumoniae | |
didanosine | - |
Streptococcus pneumoniae | |
stavudine | - |
Streptococcus pneumoniae | |
zidovudine | - |
Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UTP + alpha-D-glucose 1-phosphate | Streptococcus pneumoniae | - |
diphosphate + UDP-glucose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | Q54800 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Streptococcus pneumoniae |
Storage Stability | Organism |
---|---|
-20°C, the pure enzyme was stable for at least 6 months when stored in 20% glycerol | Streptococcus pneumoniae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UTP + alpha-D-glucose 1-phosphate | - |
Streptococcus pneumoniae | diphosphate + UDP-glucose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GalU | - |
Streptococcus pneumoniae |
UDP-glucose pyrophosphorylase | - |
Streptococcus pneumoniae |
General Information | Comment | Organism |
---|---|---|
drug target | since the eukaryotic UDP-glucose pyrophosphorylases are completely unrelated to their prokaryotic counterparts, it is propose that the GalU enzyme is a critical target to fight the pneumococcal disease. Inactivation of the galU gene completely abolishes the formation of the capsule, and, therefore, renders the pneumococcus completely avirulent. The proposed colorimetric test is as appropriate to screen and characterize specific inhibitors of GalU enzyme in the search of antipneumococcal drugs | Streptococcus pneumoniae |
physiological function | the enzyme is absolutely required for the biosynthesis of capsular polysaccharide, the virulence factor of pneumococcus | Streptococcus pneumoniae |