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EC Number General Information Commentary Reference
Show all pathways known for 2.7.7.9Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.9drug target since the eukaryotic UDP-glucose pyrophosphorylases are completely unrelated to their prokaryotic counterparts, it is propose that the GalU enzyme is a critical target to fight the pneumococcal disease. Inactivation of the galU gene completely abolishes the formation of the capsule, and, therefore, renders the pneumococcus completely avirulent. The proposed colorimetric test is as appropriate to screen and characterize specific inhibitors of GalU enzyme in the search of antipneumococcal drugs 761608
Show all pathways known for 2.7.7.9Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.9drug target UDP-mediated decrease in the virulence of Streptococcus pneumoniae. UDP is an effective inhibitor of pneumococcal UGPase 760971
Show all pathways known for 2.7.7.9Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.9evolution a feature that discriminates UGPs of different species is the quaternary organization. While UGPs in protists are monomers, di- and tetrameric forms exist in bacteria, and the enzyme from yeast and human are octameric UGPs 722370
Show all pathways known for 2.7.7.9Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.9evolution the plant UGPases belongs to the so called UGPase-A family 723370
Show all pathways known for 2.7.7.9Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.9malfunction in comparison with wild-type strain V07DF2 and complementation strains, the UGP knocked down mutant 24C9 exhibits sensitivity to sodium dodecyl sulfate (perturbing membrane integrity) and high sodium chloride concentration (high osmotic pressure stress). More than 25% of the conidia of the mutant developed into short and swollen hypha and formed hyperbranching and compact colonies. The mutant exhibits decreased virulence on cotton and tobacco seedlings. The germination of the mutant spores is significantly delayed compared with the wild-type strain on the host roots -, 761188
Show all pathways known for 2.7.7.9Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.9malfunction knockdown of rml-1, rml-4 and rml-5 (but not rml-2 and rml-3) causes lethality of the embryo 747027
Show all pathways known for 2.7.7.9Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.9malfunction lack of sulfoquinovosyldiacylglycerol in the Arabidopsis ugp3 knockout mutant. The mutant does not show significant differences in glycosides and saccharides between wild type and ugp3 mutants 723680
Show all pathways known for 2.7.7.9Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.9metabolism essential enzyme involved in carbohydrate metabolism -, 761188
Show all pathways known for 2.7.7.9Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.9metabolism in sugarcane, UDP-glucose (the product of the reaction) is a branch-point in the carbon channelling into other carbohydrates, such as sucrose and cellulose, which are the major factors for sugarcane productivity 762236
Show all pathways known for 2.7.7.9Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.9metabolism involved in cell envelope precursor synthesis -, 706591
Results 1 - 10 of 41 > >>