KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.21 | - |
geranyl triphosphate | pH 8.0, 30°C | Saccharomyces cerevisiae | |
0.32 | - |
farnesyl triphosphate | pH 8.0, 30°C | Saccharomyces cerevisiae | |
0.51 | - |
isopentenyl triphosphate | pH 8.0, 30°C | Saccharomyces cerevisiae | |
1.1 | - |
methylenebisphosphonate | pH 8.0, 30°C | Saccharomyces cerevisiae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UTP + alpha-D-glucose 1-phosphate | Saccharomyces cerevisiae | - |
diphosphate + UDP-glucose | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Saccharomyces cerevisiae | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl triphosphate + UDP-glucose | - |
Saccharomyces cerevisiae | farnesyl-tetraphosphouridine + alpha-D-glucose + diphosphate | - |
? | |
geranyl triphosphate + UDP-glucose | - |
Saccharomyces cerevisiae | geranyl-tetraphosphouridine + alpha-D-glucose + diphosphate | - |
? | |
isopentenyl triphosphate + UDP-glucose | - |
Saccharomyces cerevisiae | isopentenyl-tetraphosphouridine + alpha-D-glucose + diphosphate | - |
? | |
methylenebisphosphonate + UDP-glucose | - |
Saccharomyces cerevisiae | uridine 5'-(beta,gamma-methylenetriphosphate) + alpha-D-glucose + diphosphate | - |
? | |
additional information | the bisphosphonates alendronate, pamidronate, clodronate and etidronate are not acceptors of UMP. But UDP-glucose serves as uridylyl donor to triphosphate derivatives of the mevalonate pathway, farnesyl triphosphate, geranyl triphosphate, and isopentenyl triphosphate, with formation of farnesyl-tetraphosphouridine, geranyl-tetraphosphouridine, and isopentenyl-tetraphosphouridine, overview. No activity with farnesyl-, geranyl-, or isopentenyl-diphosphates or with dimethylallyl pyrophosphate | Saccharomyces cerevisiae | ? | - |
? | |
UTP + alpha-D-glucose 1-phosphate | - |
Saccharomyces cerevisiae | diphosphate + UDP-glucose | - |
r |
Synonyms | Comment | Organism |
---|---|---|
UTP:glucose-1-phosphate uridylyltransferase | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Saccharomyces cerevisiae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.013 | - |
isopentenyl triphosphate | pH 8.0, 30°C | Saccharomyces cerevisiae | |
0.033 | - |
farnesyl triphosphate | pH 8.0, 30°C | Saccharomyces cerevisiae | |
0.038 | - |
geranyl triphosphate | pH 8.0, 30°C | Saccharomyces cerevisiae | |
27 | - |
methylenebisphosphonate | pH 8.0, 30°C | Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Saccharomyces cerevisiae |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.025 | - |
isopentenyl triphosphate | pH 8.0, 30°C | Saccharomyces cerevisiae | |
0.103 | - |
farnesyl triphosphate | pH 8.0, 30°C | Saccharomyces cerevisiae | |
0.181 | - |
geranyl triphosphate | pH 8.0, 30°C | Saccharomyces cerevisiae | |
24.55 | - |
methylenebisphosphonate | pH 8.0, 30°C | Saccharomyces cerevisiae |