Reference on EC 2.7.12.2 - mitogen-activated protein kinase kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hunter, T.
Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling
Cell
80
225-236
1995
eukaryota
Adams, J.A.
Kinetic and catalytic mechanisms of protein kinases
Chem. Rev.
101
2271-2290
2001
eukaryota
Wood, V.; Gwilliam, R.; Rajandream, M.A.; Lyne, M.; Lyne, R.; et al.
The genome sequence of Schizosaccharomyces pombe
Nature
415
871-880
2002
Schizosaccharomyces pombe (P10506), Schizosaccharomyces pombe (P33886), Schizosaccharomyces pombe (Q9Y884)
Boyer, J.; Michaux, G.; Fairhead, C.; Gaillon, L.; Dujon, B.
Sequence and analysis of a 26.9 kb fragment from chromosome XV of the yeast Saccharomyces cerevisiae
Yeast
12
1575-1586
1996
Saccharomyces cerevisiae (P32490)
Bussey, H.; Storms, R.K.; Ahmed, A.; Albermann, K.; et al.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI
Nature
387
103-105
1997
Saccharomyces cerevisiae (P32491)
Kawai, J.; Shinagawa, A.; Shibata, K.; Yoshino, M.; Itoh, M.; et al.
Functional annotation of a full-length mouse cDNA collection
Nature
409
685-690
2001
Mus musculus (O09110)
Brewster, J.L.; de Valoir, T.; Dwyer, N.D.; Winter, E.; Gustin, M.C.
An osmosensing signal transduction pathway in yeast
Science
259
1760-1763
1993
Saccharomyces cerevisiae (P08018), Saccharomyces cerevisiae
Derijard, B.; Raingeaud, J.; Barrett, T.; Wu, I.H.; Han, J.; Ulevitch, R.J.; Davis, R.J.
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
Science
267
682-685
1995
Homo sapiens (P45985), Homo sapiens (P46734)
Zhou, G.; Bao, Z.Q.; Dixon, J.E.
Components of a new human protein kinase signal transduction pathway
J. Biol. Chem.
270
12665-12669
1995
Homo sapiens (Q13163), Homo sapiens
Tournier, C.; Whitmarsh, A.J.; Cavanagh, J.; Barrett, T.; Davis, R.J.
Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase
Proc. Natl. Acad. Sci. USA
94
7337-7342
1997
Homo sapiens (O14733)
Moriguchi, T.; Toyoshima, F.; Gotoh, Y.; Iwamatsu, A.; et al.
Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2
J. Biol. Chem.
271
26981-26988
1996
Mus musculus (O09110), Mus musculus, Homo sapiens (P46734)
Foltz, I.N.; Gerl, R.E.; Wieler, J.S.; Luckach, M.; Salmon, R.A.; Schrader, J.W.
Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli
J. Biol. Chem.
273
9344-9351
1998
Homo sapiens (O14733), Homo sapiens
Lu, X.; Nemoto, S.; Lin, A.
Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38
J. Biol. Chem.
272
24751-24754
1997
Homo sapiens (O14733)
Vitale, G.; Bernardi, L.; Napolitani, G.; Mock, M.; Montecucco, C.
Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor
Biochem. J.
352
739-745
2000
Homo sapiens (O14733), Homo sapiens (P36507), Homo sapiens (P45985), Homo sapiens (P52564), Homo sapiens (Q02750)
Wu, Z.; Wu, J.; Jacinto, E.; Karin, M.
Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase
Mol. Cell. Biol.
17
7407-7416
1997
Homo sapiens (O14733), Homo sapiens
Tobiume, K.; Inage, T.; Takeda, K.; Enomoto, S.; Miyazono, K.; Ichijo, H.
Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1
Biochem. Biophys. Res. Commun.
239
905-910
1997
Mus musculus (O35099)
Cairns, B.R.; Ramer, S.W.; Kornberg, R.D.
Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase
Genes Dev.
6
1305-1318
1992
Saccharomyces cerevisiae (P06784)
Delaveau, T.; Blugeon, C.; Jacq, C.; Perea, J.
Analysis of a 23 kb region on the left arm of yeast chromosome IV
Yeast
12
1587-1592
1996
Saccharomyces cerevisiae (P06784)
Teague, M.A.; Chaleff, D.T.; Errede, B.
Nucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases
Proc. Natl. Acad. Sci. USA
83
7371-7375
1986
Saccharomyces cerevisiae (P06784)
Zheng, C.F.; Guan, K.L.
Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues
EMBO J.
13
1123-1131
1994
Saccharomyces cerevisiae (P06784), Homo sapiens (Q02750)
Boguslawski, G.; Polazzi, J.O.
Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases
Proc. Natl. Acad. Sci. USA
84
5848-5852
1987
Saccharomyces cerevisiae (P08018)
Cziepluch, C.; Kordes, E.; Pujol, A.; Jauniaux, J.C.
Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19 open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14, RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta elements and a Ty4 transposon
Yeast
12
1471-1474
1996
Saccharomyces cerevisiae (P08018)
Maeda, T.; Takekawa, M.; Saito, H.
Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor
Science
269
554-558
1995
Saccharomyces cerevisiae (P08018), Saccharomyces cerevisiae
Nadin-Davis, S.A.; Nasim, A.
A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast
EMBO J.
7
985-993
1988
Schizosaccharomyces pombe (P10506)
Alessi, D.R.; Saito, Y.; Campbell, D.G.; Cohen, P.; Sithanandam, G.; Rapp, U.; Ashworth, A.; Marshall, C.J.; Cowley, S.
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1
EMBO J.
13
1610-1619
1994
Oryctolagus cuniculus (P29678)
Ashworth, A.; Nakielny, S.; Cohen, P.; Marshall, C.
The amino acid sequence of a mammalian MAP kinase kinase
Oncogene
7
2555-2556
1992
Oryctolagus cuniculus (P29678)
Nakielny, S.; Campbell, D.G.; Cohen, P.
MAP kinase kinase from rabbit skeletal muscle. A novel dual specificity enzyme showing homology to yeast protein kinases involved in pheromone-dependent signal transduction
FEBS Lett.
308
183-189
1992
Oryctolagus cuniculus (P29678), Oryctolagus cuniculus
Wu, J.; Michel, H.; Rossomando, A.; Haystead, T.; Shabanowitz, J.; Hunt, D.F.; Sturgill, T.W.
Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle
Biochem. J.
285
701-705
1992
Oryctolagus cuniculus (P29678)
Crews, C.M.; Alessandrini, A.; Erikson, R.L.
The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product
Science
258
478-480
1992
Mus musculus (P31938)
Crews, C.M.; Erikson, R.L.
Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product
Proc. Natl. Acad. Sci. USA
89
8205-8209
1992
Mus musculus (P31938), Mus musculus (Q63932), Mus musculus
Duesbery, N.S.; Webb, C.P.; Leppla, S.H.; Gordon, V.M.; Klimpel, K.R.; Copeland, T.D.; Ahn, N.G.; Oskarsson, M.K.; Fukasawa, K.; Paull, K.D.; Vande Woude, G.F.
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
Science
280
734-737
1998
Mus musculus (P31938), Homo sapiens (P36507), Homo sapiens (Q02750)
Irie, K.; Takase, M.; Lee, K.S.; Levin, D.E.; Araki, H.; Matsumoto, K.; Oshima, Y.
MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C
Mol. Cell. Biol.
13
3076-3083
1993
Saccharomyces cerevisiae (P32490), Saccharomyces cerevisiae (P32491)
Warbrick, E.; Fantes, P.A.
The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe
EMBO J.
10
4291-4299
1991
Schizosaccharomyces pombe (P33886), Schizosaccharomyces pombe
Otsu, M.; Terada, Y.; Okayama, H.
Isolation of two members of the rat MAP kinase kinase gene family
FEBS Lett.
320
246-250
1993
Rattus norvegicus (P36506), Rattus norvegicus (Q01986)
Wu, J.; Harrison, J.K.; Dent, P.; Lynch, K.R.; Weber, M.J.; Sturgill, T.W.
Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2
Mol. Cell. Biol.
13
4539-4548
1993
Rattus norvegicus (P36506)
Zheng, C.F.; Guan, K.L.
Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2
J. Biol. Chem.
268
11435-11439
1993
Homo sapiens (P36507), Homo sapiens (Q02750)
Fankhauser, C.; Simanis, V.
The cdc7 protein kinase is a dosage dependent regulator of septum formation in fission yeast
EMBO J.
13
3011-3019
1994
Schizosaccharomyces pombe (P41892), Schizosaccharomyces pombe
Schmidt, S.; Sohrmann, M.; Hofmann, K.; Woollard, A.; Simanis, V.
The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe
Genes Dev.
11
1519-1534
1997
Schizosaccharomyces pombe (P41892), Schizosaccharomyces pombe
Lin, A.; Minden, A.; Martinetto, H.; Claret, F.X.; Lange-Carter, C.; Mercurio, F.; Johnson, G.L.; Karin, M.
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
Science
268
286-290
1995
Homo sapiens (P45985)
Su, G.H.; Hilgers, W.; Shekher, M.C.; Tang, D.J.; Yeo, C.J.; Hruban, R.H.; Kern, S.E.
Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene
Cancer Res.
58
2339-2342
1998
Homo sapiens (P45985)
Clark, K.L.; Feldmann, P.J.; Dignard, D.; Larocque, R.; Brown, A.J.; Lee, M.G.; Thomas, D.Y.; Whiteway, M.
Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans
Mol. Gen. Genet.
249
609-621
1995
Candida albicans (P0CY25), Candida albicans
Singh, P.; Ghosh, S.; Datta, A.
A novel MAP-kinase kinase from Candida albicans
Gene
190
99-104
1997
Candida albicans (P0CY25), Candida albicans
Raingeaud, J.; Whitmarsh, A.J.; Barrett, T.; Derijard, B.; Davis, R.J.
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
Mol. Cell. Biol.
16
1247-1255
1996
Homo sapiens (P46734), Homo sapiens (P52564)
Teng, D.H.; Chen, Y.; Lian, L.; Ha, P.C.; Tavtigian, S.V.; Wong, A.K.
Mutation analyses of 268 candidate genes in human tumor cell lines
Genomics
74
352-364
2001
Homo sapiens (P46734), Homo sapiens
Sanchez, I.; Hughes, R.T.; Mayer, B.J.; Yee, K.; Woodgett, J.R.; Avruch, J.; Kyriakis, J.M.; Zon, L.I.
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
Nature
372
794-798
1994
Mus musculus (P47809)
Cuenda, A.; Alonso, G.; Morrice, N.; Jones, M.; Meier, R.; Cohen, P.; Nebreda, A.R.
Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells
EMBO J.
15
4156-4164
1996
Homo sapiens (P52564), Homo sapiens, Mus musculus (P70236), Mus musculus
Han, J.; Lee, J.D.; Jiang, Y.; Li, Z.; Feng, L.; Ulevitch, R.J.
Characterization of the structure and function of a novel MAP kinase kinase (MKK6)
J. Biol. Chem.
271
2886-2891
1996
Homo sapiens (P52564), Homo sapiens
Moriguchi, T.; Kuroyanagi, N.; Yamaguchi, K.; Gotoh, Y.; Irie, K.; Kano, T.; Shirakabe, K.; Muro, Y.; Shibuya, H.; Matsumoto, K.; Nishida, E.; Hagiwara, M.
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3
J. Biol. Chem.
271
13675-13679
1996
Homo sapiens (P52564)
Stein, B.; Brady, H.; Yang, M.X.; Young, D.B.; Barbosa, M.S.
Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade
J. Biol. Chem.
271
11427-11433
1996
Homo sapiens (P52564)
Doring, F.; Drewes, G.; Berling, B.; Mandelkow, E.M.
Cloning and sequencing of a cDNA encoding rat brain mitogen-activated protein (MAP) kinase activator
Gene
131
303-304
1993
Rattus norvegicus (Q01986)
Wu, J.; Harrison, J.K.; Vincent, L.A.; Haystead, C.; Haystead, T.A.; Michel, H.; Hunt, D.F.; Lynch, K.R.; Sturgill, T.W.
Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase
Proc. Natl. Acad. Sci. USA
90
173-177
1993
Rattus norvegicus (Q01986)
Seger, R.; Seger, D.; Lozeman, F.J.; Ahn, N.G.; Graves, L.M.; Campbell, J.S.; Ericsson, L.; Harrylock, M.; Jensen, A.M.; Krebs, E.G.
Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases
J. Biol. Chem.
267
25628-25631
1992
Homo sapiens (Q02750), Homo sapiens
Kosako, H.; Nishida, E.; Gotoh, Y.
cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates
EMBO J.
12
787-794
1993
Xenopus laevis (Q05116)
Wu, Y.; Han, M.; Guan, K.L.
MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events
Genes Dev.
9
742-755
1995
Caenorhabditis elegans (Q10664), Caenorhabditis elegans
Glise, B.; Bourbon, H.; Noselli, S.
hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement
Cell
83
451-461
1995
Drosophila melanogaster (Q23977)
Tsuda, L.; Inoue, Y.H.; Yoo, M.A.; Mizuno, M.; Hata, M.; Lim, Y.M.; Adachi-Yamada, T.; Ryo, H.; Masamune, Y.; Nishida, Y.
A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila
Cell
72
407-414
1993
Drosophila melanogaster (Q24324)
Blank, J.L.; Gerwins, P.; Elliott, E.M.; Sather, S.; Johnson, G.L.
Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase
J. Biol. Chem.
271
5361-5368
1996
Mus musculus (Q61083), Mus musculus (Q61084)
English, J.M.; Vanderbilt, C.A.; Xu, S.; Marcus, S.; Cobb, M.H.
Isolation of MEK5 and differential expression of alternatively spliced forms
J. Biol. Chem.
270
28897-28902
1995
Rattus norvegicus (Q62862)
Xu, S.; Robbins, D.J.; Christerson, L.B.; English, J.M.; Vanderbilt, C.A.; Cobb, M.H.
Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain
Proc. Natl. Acad. Sci. USA
93
5291-5295
1996
Rattus norvegicus (Q62925)
Brott, B.K.; Alessandrini, A.; Largaespada, D.A.; Copeland, N.G.; Jenkins, N.A.; Crews, C.M.; Erikson, R.L.
MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues
Cell Growth Differ.
4
921-929
1993
Mus musculus (Q63932)
Pages, G.; Brunet, A.; L'Allemain, G.; Pouyssegur, J.
Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1)
EMBO J.
13
3003-3010
1994
Cricetulus griseus (Q63980), Cricetulus griseus
Teo, M.; Manser, E.; Lim, L.
Identification and molecular cloning of a p21cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets
J. Biol. Chem.
270
26690-26697
1995
Rattus norvegicus (Q64303)
Huang, C.J.; Lee, M.S.; Chang, G.D.; Huang, F.L.; Lo, T.B.
Molecular cloning and sequencing of a carp cDNA encoding mitogen-activated protein kinase kinase
Biochim. Biophys. Acta
1220
223-225
1994
Cyprinus carpio (Q90321), Cyprinus carpio
Wang, H.; Meury, L.; Morais, R.
Cloning and characterization of cDNAs encoding chicken mitogen-activated protein kinase kinase type 2, MEK2: downregulation of MEK2 in response to inhibition of mitochondrial DNA expression
Biochemistry
36
15371-15380
1997
Gallus gallus (Q90891), Gallus gallus
Banuett, F.; Herskowitz, I.
Identification of fuz7, a Ustilago maydis MEK/MAPKK homolog required for a-locus-dependent and -independent steps in the fungal life cycle
Genes Dev.
8
1367-1378
1994
Ustilago maydis (Q99078), Ustilago maydis
Chang, H.Y.; Nishitoh, H.; Yang, X.; Ichijo, H.; Baltimore, D.
Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx
Science
281
1860-1863
1998
Homo sapiens (Q99683)
Ichijo, H.; Nishida, E.; Irie, K.; ten Dijke, P.; Saitoh, M.; Moriguchi, T.; Takagi, M.; Matsumoto, K.; Miyazono, K.; Gotoh, Y.
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
Science
275
90-94
1997
Homo sapiens (Q99683)
Wang, X.S.; Diener, K.; Jannuzzi, D.; Trollinger, D.; Tan, T.H.; Lichenstein, H.; Zukowski, M.; Yao, Z.
Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase
J. Biol. Chem.
271
31607-31611
1996
Homo sapiens (Q99683), Homo sapiens
Ellinger-Ziegelbauer, H.; Brown, K.; Kelly, K.; Siebenlist, U.
Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative
J. Biol. Chem.
272
2668-2674
1997
Homo sapiens (Q99759), Homo sapiens
Nagase, T.; Ishikawa, K.; Kikuno, R.; Hirosawa, M.; Nomura, N.; Ohara, O.
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
DNA Res.
6
337-345
1999
Homo sapiens (Q9P286)
Cheng, J.; Yang, J.; Xia, Y.; Karin, M.; Su, B.
Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation
Mol. Cell. Biol.
20
2334-2342
2000
Homo sapiens (Q9Y2U5)
Nagase, T.; Seki, N.; Ishikawa, K.; Ohira, M.; Kawarabayasi, Y.; Ohara, O.; Tanaka, A.; Kotani, H.; Miyajima, N.; Nomura, N.
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain
DNA Res.
3; 321-329
341-354
1996
Homo sapiens (Q9Y6R4)
-
Takekawa, M.; Posas, F.; Saito, H.
A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways
EMBO J.
16
4973-4982
1997
Homo sapiens (Q9Y6R4), Homo sapiens
Loewith, R.; Hubberstey, A.; Young, D.
Skh1, the MEK component of the mkh1 signaling pathway in Schizosaccharomyces pombe
J. Cell Sci.
113
153-160
2000
Schizosaccharomyces pombe (Q9Y884)
Sugiura, R.; Toda, T.; Dhut, S.; Shuntoh, H.; Kuno, T.
The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch
Nature
399
479-483
1999
Schizosaccharomyces pombe (Q9Y884), Schizosaccharomyces pombe
Zhu, H.; Klemic, J.F.; Chang, S.; Bertone, P.; Casamayor, A.; Klemic, K.G.; Smith, D.; Gerstein, M.; Reed, M.A.; Snyder, M.
Analysis of yeast protein kinases using protein chips
Nat. Genet.
26
283-289
2000
Saccharomyces cerevisiae
Jia, Y.; Quinn, C.M.; Bump, N.J.; Clark, K.M.; Clabbers, A.; Hardman, J.; Gagnon, A.; Kamens, J.; Tomlinson, M.J.; Wishart, N.; Allen, H.
Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinase COT and the complexes with its cellular partner NF-kappa B1 p105
Arch. Biochem. Biophys.
441
64-74
2005
Homo sapiens
Gil, C.; Chaib-Oukadour, I.; Aguilera, J.
C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons
Biochem. J.
373
613-620
2003
Rattus norvegicus
Liang, K.W.; Ting, C.T.; Yin, S.C.; Chen, Y.T.; Lin, S.J.; Liao, J.K.; Hsu, S.L.
Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury
Biochem. Pharmacol.
71
806-817
2006
Rattus norvegicus
Calipel, A.; Lefevre, G.; Pouponnot, C.; Mouriaux, F.; Eychene, A.; Mascarelli, F.
Mutation of B-Raf in human choroidal melanoma cells mediates cell proliferation and transformation through the MEK/ERK Pathway
J. Biol. Chem.
278
42409-42418
2003
Homo sapiens
Wallace, E.M.; Lyssikatos, J.; Blake, J.F.; Seo, J.; Yang, H.W.; Yeh, T.C.; Perrier, M.; Jarski, H.; Marsh, V.; Poch, G.; Livingston, M.G.; Otten, J.; Hingorani, G.; Woessner, R.; Lee, P.; Winkler, J.; Koch, K.
Potent and selective mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors. 4-(4-Bromo-2-fluorophenylamino)-1-methylpyridin-2(1H)-ones
J. Med. Chem.
49
441-444
2006
Homo sapiens
Atwal, J.K.; Singh, K.K.; Tessier-Lavigne, M.; Miller, F.D.; Kaplan, D.R.
Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse
J. Neurosci.
23
7602-7609
2003
Rattus norvegicus
Kuhn, D.; Wiese, M.
LmxPK4, a mitogen-activated protein kinase kinase homologue of Leishmania mexicana with a potential role in parasite differentiation
Mol. Microbiol.
56
1169-1182
2005
Leishmania mexicana (Q9GRT1), Leishmania mexicana
Karim, F.; Hu, H.J.; Adwanikar, H.; Kaplan, D.R.; Gereau, R.W.T.
Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK)
Mol. Pain
2
2
2006
Mus musculus
Tan, X.; Tamori, Y.; Egami, H.; Ishikawa, S.; Kurizaki, T.; Takai, E.; Hirota, M.; Ogawa, M.
Analysis of invasion-metastasis mechanism in pancreatic cancer: involvement of tight junction transmembrane protein occludin and MEK/ERK signal transduction pathway in cancer cell dissociation
Oncol. Rep.
11
993-998
2004
Mesocricetus auratus
Michael, L.; Swantek, J.; Robinson, M.J.
Cloning and expression of human mitogen-activated protein kinase kinase 7gamma1
Biochem. Biophys. Res. Commun.
341
679-683
2006
Homo sapiens (O14733), Homo sapiens
Gibbs, G.M.; Bianco, D.M.; Jamsai, D.; Herlihy, A.; Ristevski, S.; Aitken, R.J.; Kretser, D.M.; OBryan, M.K.
Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm
Biol. Reprod.
77
108-114
2007
Mus musculus
Hsu, C.L.; Kikuchi, K.; Kondo, M.
Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment
Blood
110
1420-1428
2007
Mus musculus
Cunningham, S.C.; Kamangar, F.; Kim, M.P.; Hammoud, S.; Haque, R.; Iacobuzio-Donahue, C.A.; Maitra, A.; Ashfaq, R.; Hustinx, S.; Heitmiller, R.E.; Choti, M.A.; Lillemoe, K.D.; Cameron, J.L.; Yeo, C.J.; Schulick, R.D.; Montgomery, E.
Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions
Cancer Epidemiol. Biomarkers Prev.
15
281-287
2006
Homo sapiens
Kojima, K.; Konopleva, M.; Samudio, I.J.; Ruvolo, V.; Andreeff, M.
Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells
Cancer Res.
67
3210-3219
2007
Homo sapiens
Ross, K.R.; Corey, D.A.; Dunn, J.M.; Kelley, T.J.
SMAD3 expression is regulated by mitogen-activated protein kinase kinase-1 in epithelial and smooth muscle cells
Cell. Signal.
19
923-931
2007
Homo sapiens
Lee, S.D.; Chang, S.H.; Kuo, W.H.; Ying, T.H.; Kuo, W.W.; Li, P.C.; Hsu, H.H.; Lu, M.C.; Ting, H.; Huang, C.Y.
Role of mitogen-activated protein kinase kinase in Porphyromonas gingivalis-induced myocardial cell hypertrophy and apoptosis
Eur. J. Oral Sci.
114
154-159
2006
Rattus norvegicus
Xia, D.; Srinivas, H.; Ahn, Y.H.; Sethi, G.; Sheng, X.; Yung, W.K.; Xia, Q.; Chiao, P.J.; Kim, H.; Brown, P.H.; Wistuba, I.I.; Aggarwal, B.B.; Kurie, J.M.
Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway
J. Biol. Chem.
282
3507-3519
2007
Mus musculus
Spicer, J.A.; Rewcastle, G.W.; Kaufman, M.D.; Black, S.L.; Plummer, M.S.; Denny, W.A.; Quin, J.; Shahripour, A.B.; Barrett, S.D.; Whitehead, C.E.; Milbank, J.B.; Ohren, J.F.; Gowan, R.C.; Omer, C.; Camp, H.S.; Esmaeil, N.; Moore, K.; Sebolt-Leopold, J.S.; Pryzbranowski, S.; Merriman, R.L.; Ortwine, D.F.; Warmus,
4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase
J. Med. Chem.
50
5090-5102
2007
Mus musculus, Mus musculus (P31938), Mus musculus (Q63932)
Feinstein, T.N.; Linstedt, A.D.
Mitogen-activated protein kinase kinase 1-dependent Golgi unlinking occurs in G2 phase and promotes the G2/M cell cycle transition
Mol. Biol. Cell
18
594-604
2007
Homo sapiens
Demuth, T.; Reavie, L.B.; Rennert, J.L.; Nakada, M.; Nakada, S.; Hoelzinger, D.B.; Beaudry, C.E.; Henrichs, A.N.; Anderson, E.M.; Berens, M.E.
MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival
Mol. Cancer Ther.
6
1212-1222
2007
Homo sapiens (P46734), Homo sapiens
Whitmarsh, A.J.; Davis, R.J.
Role of mitogen-activated protein kinase kinase 4 in cancer
Oncogene
26
3172-3184
2007
Drosophila melanogaster, Homo sapiens, Homo sapiens (O14733), Homo sapiens (P45985), Mus musculus, Mus musculus (P47809), Mus musculus (Q8CE90), Rattus norvegicus, Xenopus laevis
Doczi, R.; Brader, G.; Pettko-Szandtner, A.; Rajh, I.; Djamei, A.; Pitzschke, A.; Teige, M.; Hirt, H.
The Arabidopsis mitogen-activated protein kinase kinase MKK3 is upstream of group C mitogen-activated protein kinases and participates in pathogen signaling
Plant Cell
19
3266-3279
2007
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Chen, Y.C.; Lin, H.H.; Jeng, S.T.
Calcium influxes and mitogen-activated protein kinase kinase activation mediate ethylene inducing ipomoelin gene expression in sweet potato
Plant Cell Environ.
31
62-72
2007
Ipomoea batatas
Mokhtari, D.; Myers, J.W.; Welsh, N.
The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death
Endocrinology
149
3046-3053
2008
Homo sapiens
Hansen, T.E.; Puntervoll, P.; Seternes, O.M.; J?rgensen, J.B.
Atlantic salmon possess three mitogen activated protein kinase kinase 6 paralogs responding differently to stress
FEBS J.
275
4887-4902
2008
Salmo salar (A9UK00), Salmo salar
Chen, Y.C.; Huang, S.H.; Wang, S.M.
Adenosine-stimulated adrenal steroidogenesis involves the adenosine A2A and A2B receptors and the Janus kinase 2-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase signaling pathway
Int. J. Biochem. Cell Biol.
40
2815-2825
2008
Rattus norvegicus
Kang, N.J.; Lee, K.W.; Lee, D.E.; Rogozin, E.A.; Bode, A.M.; Lee, H.J.; Dong, Z.
Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase
J. Biol. Chem.
283
20664-20673
2008
Mus musculus (P31938), Mus musculus
Xia, Y.; Wang, C.Z.; Liu, J.; Anastasio, N.C.; Johnson, K.M.
Lithium protection of phencyclidine-induced neurotoxicity in developing brain: the role of phosphatidylinositol-3 kinase/Akt and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathways
J. Pharmacol. Exp. Ther.
326
838-848
2008
Rattus norvegicus
Ding, Y.; Boguslawski, E.A.; Berghuis, B.D.; Young, J.J.; Zhang, Z.; Hardy, K.; Furge, K.; Kort, E.; Frankel, A.E.; Hay, R.V.; Resau, J.H.; Duesbery, N.S.
Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma
Mol. Cancer Ther.
7
648-658
2008
Homo sapiens
Grund, E.M.; Kagan, D.; Tran, C.A.; Zeitvogel, A.; Starzinski-Powitz, A.; Nataraja, S.; Palmer, S.S.
Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells
Mol. Pharmacol.
73
1394-1404
2008
Homo sapiens
Qiu, J.L.; Zhou, L.; Yun, B.W.; Nielsen, H.B.; Fiil, B.K.; Petersen, K.; Mackinlay, J.; Loake, G.J.; Mundy, J.; Morris, P.C.
Arabidopsis mitogen-activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1
Plant Physiol.
148
212-222
2008
Arabidopsis thaliana (Q94A06), Arabidopsis thaliana (Q9S7U9)
Kumar, K.; Rao, K.P.; Sharma, P.; Sinha, A.K.
Differential regulation of rice mitogen activated protein kinase kinase (MKK) by abiotic stress
Plant Physiol. Biochem.
46
891-897
2008
Oryza sativa (A2XE35), Oryza sativa (A3FK65), Oryza sativa (Q0MSI2), Oryza sativa (Q0Z7Z4), Oryza sativa (Q5QN75), Oryza sativa
Wang, X.; Ye, X.L.; Liu, R.; Chen, H.L.; Bai, H.; Liang, X.; Zhang, X.D.; Wang, Z.; Li, W.L.; Hai, C.X.
Antioxidant activities of oleanolic acid in vitro: possible role of Nrf2 and MAP kinases
Chem. Biol. Interact.
184
328-337
2010
Homo sapiens
Maharjan, S.; Serova, L.I.; Sabban, E.L.
Membrane-initiated estradiol signaling increases tyrosine hydroxylase promoter activity with ERalpha in PC12 cells
J. Neurochem.
112
42-55
2010
Rattus norvegicus
Cully, M.; Genevet, A.; Warne, P.; Treins, C.; Liu, T.; Bastien, J.; Baum, B.; Tapon, N.; Leevers, S.J.; Downward, J.
A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1
Mol. Cell. Biol.
30
481-495
2010
Homo sapiens
Zheng, L.S.; Zhang, Y.Y.; Wu, J.W.; Wu, Z.; Zhang, Z.Y.; Wang, Z.X.
A continuous spectrophotometric assay for mitogen-activated protein kinase kinases
Anal. Biochem.
421
191-197
2012
Homo sapiens (P52564), Homo sapiens (Q02750)
Matsumoto, T.; Kinoshita, T.; Kirii, Y.; Tada, T.; Yamano, A.
Crystal and solution structures disclose a putative transient state of mitogen-activated protein kinase kinase 4
Biochem. Biophys. Res. Commun.
425
195-200
2012
Homo sapiens (P45985)
Borthakur, G.; Popplewell, L.; Boyiadzis, M.; Foran, J.; Platzbecker, U.; Vey, N.; Walter, R.B.; Olin, R.; Raza, A.; Giagounidis, A.; Al-Kali, A.; Jabbour, E.; Kadia, T.; Garcia-Manero, G.; Bauman, J.W.; Wu, Y.; Liu, Y.; Schramek, D.; Cox, D.S.; Wissel, P.; Kantarjian, H.
Activity of the oral mitogen-activated protein kinase kinase inhibitor trametinib in RAS-mutant relapsed or refractory myeloid malignancies
Cancer
122
1871-1879
2016
Homo sapiens (P36507), Homo sapiens (Q02750), Homo sapiens
Low, H.; Chua, C.S.; Sim, T.-S.
Plasmodium falciparum possesses a unique dual-specificity serine/threonine and tyrosine kinase, Pfnek3
Cell. Mol. Life Sci.
69
1523-1535
2012
Plasmodium falciparum
Yari, H.; Ganjalikhany, M.R.; Sadegh, H.
In silico investigation of new binding pocket for mitogen activated kinase kinase (MEK): development of new promising inhibitors
Comput. Biol. Chem.
59 Pt A
185-198
2015
Homo sapiens
Jensen, B.C.; Kifer, C.T.; Parsons, M.
Trypanosoma brucei: two mitogen activated protein kinase kinases are dispensable for growth and virulence of the bloodstream form
Exp. Parasitol.
128
250-255
2011
Trypanosoma brucei brucei (Q38B76), Trypanosoma brucei brucei (Q582P9), Trypanosoma brucei brucei 927/4 (Q38B76), Trypanosoma brucei brucei 927/4 (Q582P9)
Chapman, M.S.; Miner, J.N.
Novel mitogen-activated protein kinase kinase inhibitors
Expert Opin. Investig. Drugs
20
209-220
2011
Homo sapiens
Tian, L.; Wang, Y.; Yu, J.; Xiong, D.; Zhao, H.; Tian, C.
The mitogen-activated protein kinase kinase VdPbs2 of Verticillium dahliae regulates microsclerotia formation, stress response, and plant infection
Front. Microbiol.
7
1532
2016
Verticillium dahliae, Verticillium dahliae XS11
Yan, L.; Yang, Q.; Sundin, G.W.; Li, H.; Ma, Z.
The mitogen-activated protein kinase kinase BOS5 is involved in regulating vegetative differentiation and virulence in Botrytis cinerea
Fungal Genet. Biol.
47
753-760
2010
Botrytis cinerea (I7FWY1), Botrytis cinerea, Botrytis cinerea 38B1 (I7FWY1)
Jo, C.; Cho, S.J.; Jo, S.A.
Mitogen-activated protein kinase kinase 1 (MEK1) stabilizes MyoD through direct phosphorylation at tyrosine 156 during myogenic differentiation
J. Biol. Chem.
286
18903-18913
2011
Homo sapiens (Q02750)
Wang, J.; Chen, L.; Ko, C.I.; Zhang, L.; Puga, A.; Xia, Y.
Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation
J. Biol. Chem.
287
2787-2797
2012
Mus musculus (P47809), Mus musculus (Q8CE90)
Uchida, Y.; Osaki, T.; Yamasaki, T.; Shimomura, T.; Hata, S.; Horikawa, K.; Shibata, S.; Todo, T.; Hirayama, J.; Nishina, H.
Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock
J. Biol. Chem.
287
8318-8326
2012
Homo sapiens (O14733), Mus musculus (Q8CE90), Mus musculus
Ripple, M.; Kim, N.; Springett, R.
Acute mitochondrial inhibition by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) 1/2 inhibitors regulates proliferation
J. Biol. Chem.
288
2933-2940
2013
Homo sapiens (P36507), Homo sapiens (Q02750)
Xing, Y.; Chen, W.H.; Jia, W.; Zhang, J.
Mitogen-activated protein kinase kinase 5 (MKK5)-mediated signalling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress
J. Exp. Bot.
66
5971-5981
2015
Arabidopsis thaliana (Q8RXG3)
Cai, G.; Wang, G.; Wang, L.; Liu, Y.; Pan, J.; Li, D.
A maize mitogen-activated protein kinase kinase, ZmMKK1, positively regulated the salt and drought tolerance in transgenic Arabidopsis
J. Plant Physiol.
171
1003-1016
2014
Zea mays (Q94EV7), Zea mays
Wang, J.; Chen, S.; Liao, Y.; Zhang, E.; Feng, S.; Yu, S.; Li, L.F.; He, W.R.; Li, Y.; Luo, Y.; Sun, Y.; Zhou, M.; Wang, X.; Munir, M.; Li, S.; Qiu, H.J.
Mitogen-activated protein kinase kinase 2 (MEK2), a novel E2-interacting protein, promotes the growth of classical swine fever virus via attenuation of the JAK-STAT signaling pathway
J. Virol.
90
10271-10283
2016
Sus scrofa (I3L5D4)
Geng, P.; Ou, J.; Xie, G.; Li, J.; Zhao, X.; Xiang, L.; Liao, Y.; Wang, N.; Liang, H.
Mitogen-activated protein kinase kinase 4 gene polymorphism and cancer risk
Medicine (Baltimore)
94
e0938
2015
Homo sapiens (P45985)
Lee, H.
Mitogen-activated protein kinase kinase 3 is required for regulation during dark-light transition
Mol. Cells
38
651-656
2015
Arabidopsis thaliana (O80396)
Wang, L.; Chen, C.; Feng, S.; Lei, P.; Tian, J.
Mitogen-activated protein kinase kinase 3 induces cell cycle arrest via p38 activation mediated Bmi-1 downregulation in hepatocellular carcinoma
Mol. Med. Rep.
13
243-248
2016
Homo sapiens (P46734)
Moretti, M.; Rossi, M.; Ciuffo, M.; Turina, M.
Functional characterization of the three mitogen-activated protein kinase kinases (MAP2Ks) present in the Cryphonectria parasitica genome reveals the necessity of Cpkk1 and Cpkk2, but not Cpkk3, for pathogenesis on chestnut (Castanea spp.)
Mol. Plant Pathol.
15
500-512
2014
Cryphonectria parasitica (B2ZAW3), Cryphonectria parasitica (O93876), Cryphonectria parasitica
Wang, C.; Lu, W.; He, X.; Wang, F.; Zhou, Y.; Guo, X.; Guo, X.
The cotton mitogen-activated protein kinase kinase 3 functions in drought tolerance by regulating stomatal responses and root growth
Plant Cell Physiol.
57
1629-1642
2016
Gossypium hirsutum (S4S5K3), Gossypium hirsutum
Chen, T.; Zhu, H.; Ke, D.; Cai, K.; Wang, C.; Gou, H.; Hong, Z.; Zhang, Z.
A MAP kinase kinase interacts with SymRK and regulates nodule organogenesis in Lotus japonicus
Plant Cell
24
823-838
2012
Lotus japonicus (F8THZ4), Lotus japonicus
Lampard, G.R.; Wengier, D.L.; Bergmann, D.C.
Manipulation of mitogen-activated protein kinase kinase signaling in the Arabidopsis stomatal lineage reveals motifs that contribute to protein localization and signaling specificity
Plant Cell
26
3358-3371
2014
Arabidopsis thaliana
Duan, P.; Rao, Y.; Zeng, D.; Yang, Y.; Xu, R.; Zhang, B.; Dong, G.; Qian, Q.; Li, Y.
SMALL GRAIN 1, which encodes a mitogen-activated protein kinase kinase 4, influences grain size in rice
Plant J.
77
547-557
2014
Oryza sativa Japonica Group (Q0DWY3)
Kumar, K.; Sinha, A.K.
Genome-wide transcriptome modulation in rice transgenic lines expressing engineered mitogen activated protein kinase kinase 6
Plant Signal. Behav.
9
e28502
2014
Oryza sativa Indica Group (Q0Z7Z4)
Wankhede, D.P.; Misra, M.; Singh, P.; Sinha, A.K.
Rice mitogen activated protein kinase kinase and mitogen activated protein kinase interaction network revealed by in-silico docking and yeast two-hybrid approaches
PLoS ONE
8
e65011
2013
Oryza sativa Indica Group (A2XE35), Oryza sativa Indica Group (A3FK65), Oryza sativa Indica Group (A5A544), Oryza sativa Indica Group (I3RJI6), Oryza sativa Indica Group (Q0Z7Z4)
Kumar, K.; Sinha, A.K.
Overexpression of constitutively active mitogen activated protein kinase kinase 6 enhances tolerance to salt stress in rice
Rice (N.Y.)
6
25
2013
Oryza sativa Indica Group (Q0Z7Z4)
Luo, J.; Wang, X.; Feng, L.; Li, Y.; He, J.X.
The mitogen-activated protein kinase kinase 9 (MKK9) modulates nitrogen acquisition and anthocyanin accumulation under nitrogen-limiting condition in Arabidopsis
Biochem. Biophys. Res. Commun.
487
539-544
2017
Arabidopsis thaliana (Q9FX43)
Kinoshita, T.; Hashimoto, T.; Sogabe, Y.; Fukada, H.; Matsumoto, T.; Sawa, M.
High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 7
Biochem. Biophys. Res. Commun.
493
313-317
2017
Homo sapiens (O14733)
Tang, Z.; Cao, X.; Zhang, Y.; Jiang, J.; Qiao, D.; Xu, H.; Cao, Y.
Two splice variants of the DsMEK1 mitogen-activated protein kinase kinase (MAPKK) are involved in salt stress regulation in Dunaliella salina in different ways
Biotechnol. Biofuels
13
147
2020
Dunaliella salina
Nakamura, S.; Pourkheirandish, M.; Morishige, H.; Kubo, Y.; Nakamura, M.; Ichimura, K.; Seo, S.; Kanamori, H.; Wu, J.; Ando, T.; Hensel, G.; Sameri, M.; Stein, N.; Sato, K.; Matsumoto, T.; Yano, M.; Komatsuda, T.
Mitogen-activated protein kinase kinase 3 regulates seed dormancy in barley
Curr. Biol.
26
775-781
2016
Hordeum vulgare (A0A140JZ28), Hordeum vulgare
Lin, C.; Huang, G.; Zheng, F.; Miao, W.
Functional characterization of CgPBS2, a MAP kinase kinase in Colletotrichum gloeosporioides, using osmotic stress sensitivity as a selection marker
Eur. J. Plant Pathol.
152
801-813
2018
Colletotrichum gloeosporioides (A0A0X9RLL5)
-
Benhamman, R.; Bai, F.; Drory, S.; Loubert-Hudon, A.; Ellis, B.; Matton, D.
The Arabidopsis mitogen-activated protein kinase kinase kinase 20 (MKKK20) acts upstream of MKK3 and MPK18 in two separate signaling pathways involved in root microtubule functions
Front. Plant Sci.
8
1352
2017
Arabidopsis thaliana (O80396)
Liang, Q.; Li, B.; Wang, J.; Ren, P.; Yao, L.; Meng, Y.; Si, E.; Shang, X.; Wang, H.
PGPBS, a mitogen-activated protein kinase kinase, is required for vegetative differentiation, cell wall integrity, and pathogenicity of the barley leaf stripe fungus Pyrenophora graminea
Gene
696
95-104
2019
Pyrenophora graminea (A0A5H2QD04), Pyrenophora graminea
Yang, C.; Wang, R.; Gou, L.; Si, Y.; Guan, Q.
Overexpression of Populus trichocarpa mitogen-activated protein kinase kinase4 enhances salt tolerance in tobacco
Int. J. Mol. Sci.
18
2090
2017
Populus trichocarpa
Khanam, U.; Malik, B.; Mathur, P.; Rathi, B.
Identification of novel inhibitors for mitogen-activated protein kinase kinase 4 by virtual screening and molecular dynamics simulation techniques
Int. J. Pharm. Pharm. Sci.
8
262-268
2016
Homo sapiens (P45985)
-
Bassi, R.; Burgoyne, J.R.; DeNicola, G.F.; Rudyk, O.; DeSantis, V.; Charles, R.L.; Eaton, P.; Marber, M.S.
Redox-dependent dimerization of p38alpha mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3
J. Biol. Chem.
292
16161-16173
2017
Rattus norvegicus (B1H230)
Kugeratski, F.G.; Batista, M.; Lima, C.V.P.; Neilson, L.J.; da Cunha, E.S.; de Godoy, L.M.; Zanivan, S.; Krieger, M.A.; Marchini, F.K.
Mitogen-activated protein kinase kinase 5 regulates proliferation and biosynthetic processes in procyclic forms of Trypanosoma brucei
J. Proteome Res.
17
108-118
2018
Trypanosoma brucei (Q38B76), Trypanosoma brucei, Trypanosoma brucei 927/4 GUTat10.1 (Q38B76)
Gibson, E.S.; Woolfrey, K.M.; Li, H.; Hogan, P.G.; Nemenoff, R.A.; Heasley, L.E.; DellAcqua, M.L.
Subcellular localization and activity of the mitogen-activated protein kinase kinase 7 (MKK7) gamma isoform are regulated through binding to the phosphatase calcineurin
Mol. Pharmacol.
95
20-32
2019
Homo sapiens (O14733)
Chang, Y.; Yang, H.; Ren, D.; Li, Y.
Activation of ZmMKK10, a maize mitogen-activated protein kinase kinase, induces ethylene-dependent cell death
Plant Sci.
264
129-137
2017
Zea mays (A0A1D6GJ58), Zea mays
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