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Literature summary for 2.7.12.2 extracted from

  • Tian, L.; Wang, Y.; Yu, J.; Xiong, D.; Zhao, H.; Tian, C.
    The mitogen-activated protein kinase kinase VdPbs2 of Verticillium dahliae regulates microsclerotia formation, stress response, and plant infection (2016), Front. Microbiol., 7, 1532.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.2

Protein Variants

Protein Variants Comment Organism
additional information targeted disruption of gene VdPbs2 and mutant complementation with the VdPbs2-GFP fusion construct containing the native promoter and coding region of VdPbs2 Verticillium dahliae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Verticillium dahliae 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Verticillium dahliae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Verticillium dahliae
-
 ADP + a phosphoprotein
-
 ?
ATP + a protein Verticillium dahliae XS11
-
 ADP + a phosphoprotein
-
 ?
ATP + VdHog1 Verticillium dahliae VdHog1 is a mitogen-activated protein kinase, MAPK ADP + phosphorylated VdHog1
-
 ?
ATP + VdHog1 Verticillium dahliae XS11 VdHog1 is a mitogen-activated protein kinase, MAPK ADP + phosphorylated VdHog1
-
 ?

Organism

Organism UniProt Comment Textmining
Verticillium dahliae
-
 isolated from a smoke tree, Cotinuscoggygria in Fragrant Hills Park,Beijing
-
Verticillium dahliae XS11
-
 isolated from a smoke tree, Cotinuscoggygria in Fragrant Hills Park,Beijing
-

Source Tissue

Source Tissue Comment Organism Textmining
conidium
-
 Verticillium dahliae
-
microsclerotium
-
 Verticillium dahliae
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Verticillium dahliae ADP + a phosphoprotein
-
 ?
ATP + a protein
-
 Verticillium dahliae XS11 ADP + a phosphoprotein
-
 ?
ATP + VdHog1 VdHog1 is a mitogen-activated protein kinase, MAPK Verticillium dahliae ADP + phosphorylated VdHog1
-
 ?
ATP + VdHog1 VdHog1 is a mitogen-activated protein kinase, MAPK Verticillium dahliae XS11 ADP + phosphorylated VdHog1
-
 ?

Synonyms

Synonyms Comment Organism
MAPKK
-
 Verticillium dahliae
MEK
-
 Verticillium dahliae
mitogen-activated protein kinase kinase
-
 Verticillium dahliae
VdPbs2
-
 Verticillium dahliae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Verticillium dahliae

General Information

General Information Comment Organism
malfunction VdPbs2 deletion strains exhibit delayed melanin synthesis and reduced formation of microsclerotia, similar to a VdHog1 deletion mutant. When exposed to stresses, VdPbs2 mutants are more sensitive than the wild-type to osmotic agents and peroxide, but more resistant to inhibitors of cell wall synthesis and some fungicides. VdPbs2 deletion mutants exhibit reduced virulence on smoke tree and tobacco seedlings. Transcript analysis revealed´s that three genes(VDAG_08724, VDAG_03661,and VDAG_06340) are consistently downregulated in the 1VdPbs2 mutant compared to that of the wild-type after treated with 1 mM H2O2 for 30 min. Phentypes, overview Verticillium dahliae
physiological function mitogen-activated protein kinase kinase VdPbs2 is a key regulator of microsclerotia formation, oxidative stress and fungicide response and plant virulence in Verticillium dahliae via regulating the activity of VdHog1, a mitogen-activated protein kinase, MAPK. VdPbs2 and VdHog1 function in a cascade that regulates microsclerotia formation and virulence, but not all VdHog1 dependent functions are VdPbs2 regulated. VdPbs2 is essential for the oxidative stress response and is required for plant infection, VdPbs2 may be involved in the penetration process during plant infection Verticillium dahliae