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Literature summary for 2.7.12.2 extracted from

  • Liang, K.W.; Ting, C.T.; Yin, S.C.; Chen, Y.T.; Lin, S.J.; Liao, J.K.; Hsu, S.L.
    Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury (2006), Biochem. Pharmacol., 71, 806-817.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information MEK and ERK are activated by phosphorylation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after mechanical injury in vitro Rattus norvegicus
U0126 specific MEK inhibitor Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. activation of Egr-1 and subsequently of c-Fos and cyclin D1 after mechanic injury for induction/regulation of regrowth of smooth vascular cells, vascular smooth muscle cell proliferation plays an important role in pathogenesis of atherosclerosis and post-angioplasty restenosis, overview ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 Sprague-Dawley rats
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein MEK and ERK are activated by phosphorylation Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell aortic, cell culture Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. activation of Egr-1 and subsequently of c-Fos and cyclin D1 after mechanic injury for induction/regulation of regrowth of smooth vascular cells, vascular smooth muscle cell proliferation plays an important role in pathogenesis of atherosclerosis and post-angioplasty restenosis, overview Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
ERK
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 Rattus norvegicus
extracellular-signal-regulated kinase
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 Rattus norvegicus
MEK1
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 Rattus norvegicus
MEK2
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 Rattus norvegicus
mitogen-activated protein kinase kinase 1
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 Rattus norvegicus
mitogen-activated protein kinase kinase 2
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 Rattus norvegicus