Literature summary for 2.7.12.2 extracted from

Moriguchi, T.; Toyoshima, F.; Gotoh, Y.; Iwamatsu, A.; et al.
Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2 (1996), J. Biol. Chem., 271, 26981-26988.

Search for more literature for 2.7.12.2

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in COS7 cells	Mus musculus
expressed in COS7 cells	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + protein	Mus musculus	enzyme is the major activator for p38	ADP + phosphoprotein	-	?
ATP + protein	Homo sapiens	enzyme is the major activator for p38	ADP + phosphoprotein	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P46734	-	-
Mus musculus	O09110	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
L-5178-Y cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + protein	enzyme is the major activator for p38	Mus musculus	ADP + phosphoprotein	-	?
ATP + protein	enzyme is the major activator for p38	Homo sapiens	ADP + phosphoprotein	-	?

Synonyms

Synonyms	Comment	Organism
dual specificity mitogen-activated protein kinase kinase 3	-	Mus musculus
dual specificity mitogen-activated protein kinase kinase 3	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)