Literature summary for 2.7.12.2 extracted from

Hsu, C.L.; Kikuchi, K.; Kondo, M.
Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment (2007), Blood, 110, 1420-1428.

Search for more literature for 2.7.12.2

Application

Application	Comment	Organism
additional information	MEK/ERK pathway plays an important role in myeloid differentiation, especially granulocyte/macrophage lineage commitment, not only in ectopic interleukin-2 driven lineage conversion in common lymphoid progenitors but also in physiologic hematopoiesis	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
constitutive active form of MEK1 and siRNA-targeting MEK1 cloned into MSCV-IRES-GFP vector, retrovirally transduced to HSCs and injected into sublethally irradiated RAG2-/- (CD42.2) mice	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
PD98059	inhibitor specific for MEK/ERK activation, granulocyte/macrophage colony number is decreased by ca. 60%	Mus musculus
siRNA	knockdown of MEK, HSCs give rise to Mac-1+ myeloid cells less efficiently than control HSCs	Mus musculus
U0126	inhibitor specific for MEK/ERK activation, granulocyte/macrophage colony number is decreased by ca. 60%	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57B/Ka-Thy1.1 mice at 6-10 weeks of age	-

Synonyms

Synonyms	Comment	Organism
MEK/ERK	-	Mus musculus
MEK1	-	Mus musculus
mitogen-activated protein kinase kinase/extracellular signalregulated kinase	-	Mus musculus

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Release 2023.1 (January 2023)