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Literature summary for 2.7.12.2 extracted from
- Mitogen-activated protein kinase kinase 5 regulates proliferation and biosynthetic processes in procyclic forms of Trypanosoma brucei (2018), J. Proteome Res., 17, 108-118 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma brucei | Q38B76 | - |
- |
| Trypanosoma brucei 927/4 GUTat10.1 | Q38B76 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MKK5 | - |
Trypanosoma brucei |
| Tb10.70.1800 | - |
Trypanosoma brucei |
| Tb927.10.5270 | - |
Trypanosoma brucei |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the silencing of MKK5 significantly decreases the proliferation of procyclic forms of Trypanosoma brucei. In the total proteome, a general decrease in proteins related to ribosome and translation as well as down-regulation of several components of the fatty acids biosynthesis pathway are observed. In addition, alterations in the protein levels and phosphorylation of key metabolic enzymes are observed | Trypanosoma brucei |
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