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Literature summary for 2.7.12.2 extracted from

  • Pages, G.; Brunet, A.; L'Allemain, G.; Pouyssegur, J.
    Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1) (1994), EMBO J., 13, 3003-3010.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.2

Protein Variants

Protein Variants Comment Organism
D208N mutation abolishes MAPKK activity Cricetulus griseus
S222A mutation abolishes MAPKK activity, shows a reduction in phosphorylation in response to active MAPKKK and exerts a dominant negative effect on the serum-stimulated endogenous MAPKK Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus Q63980
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Ser222 represents one key MAPKKK-dependent phosphorylation site switching on and off the activity of MAPKK, an event crucial for growth control Cricetulus griseus

Synonyms

Synonyms Comment Organism
dual specificity mitogen-activated protein kinase kinase 1
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 Cricetulus griseus
mammalian MAP kinase kinase
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 Cricetulus griseus
MEK1
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 Cricetulus griseus