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Literature summary for 2.7.12.2 extracted from

  • Ichijo, H.; Nishida, E.; Irie, K.; ten Dijke, P.; Saitoh, M.; Moriguchi, T.; Takagi, M.; Matsumoto, K.; Miyazono, K.; Gotoh, Y.
    Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways (1997), Science, 275, 90-94.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is activated in cells treated with tumor necrosis factor-alpha Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein Homo sapiens ASK1 may be a key element in the mechanism of stress-induced and cytokine-induced apoptosis ADP + phosphoprotein
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q99683
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein ASK1 may be a key element in the mechanism of stress-induced and cytokine-induced apoptosis Homo sapiens ADP + phosphoprotein
-
?

Synonyms

Synonyms Comment Organism
ASK1
-
Homo sapiens
MAPKKK5
-
Homo sapiens
mitogen-activated protein kinase kinase kinase 5
-
Homo sapiens