Literature summary for 2.7.12.2 extracted from

Gibson, E.S.; Woolfrey, K.M.; Li, H.; Hogan, P.G.; Nemenoff, R.A.; Heasley, L.E.; DellAcqua, M.L.
Subcellular localization and activity of the mitogen-activated protein kinase kinase 7 (MKK7) gamma isoform are regulated through binding to the phosphatase calcineurin (2019), Mol. Pharmacol., 95, 20-32 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O14733	alternative splicing of a single exon within the N-terminal domain leads to MKK7gamma encoding a unique PxIxITmotif (PIIVIT) that is not present in MKK7alpha or beta	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
vascular smooth muscle	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MAP2K7	-	Homo sapiens
MKK7	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	isoform MKK7gamma, product of alternative splicing, binds directly to calcineurin through its PIIVIT motif in vitro, immunoprecipitates with calcineurin from cell extracts, and exhibits fluorescence resonance energy transfer with calcineurin in the cytoplasm but not in the nucleus of living cells. Isoforms alpha and beta exhibit no direct binding or fluorescence resonance energy transfer with calcineurin and are localized more in the nucleus than the cytoplasm. The inhibition of calcineurin phosphatase activity increases the basal phosphorylation of MKK7gamma but not MKK7beta. Deletion of the MKK7gamma PIIVIT motif eliminates FRET with calcineurin and promotes MKK7gamma redistribution to the nucleus. The inhibition of calcineurin phosphatase activity in vascular smooth muscle cells, which express MKK7gamma mRNA, enhances c-Jun N-terminal kinase activation	Homo sapiens

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Release 2023.1 (January 2023)