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Abortion, Spontaneous
HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans.
Acquired Immunodeficiency Syndrome
Distinguishing the optimal binding mechanism of an E3 ubiquitin ligase: Covalent versus noncovalent inhibition.
Acute Kidney Injury
cMet agonistic antibody prevents acute kidney injury to chronic kidney disease transition by suppressing Smurf1 and activating Smad7.
Adenocarcinoma
Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis.
Adenocarcinoma
The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer.
Adenocarcinoma of Lung
ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of ?-catenin by upregulating the E3 ligase NEDD4L.
Adenocarcinoma of Lung
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53.
Adenocarcinoma of Lung
Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.
Adenocarcinoma of Lung
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
Adenocarcinoma of Lung
Ubiquitination of heat shock protein 27 is mediated by its interaction with Smad ubiquitination regulatory factor 2 in A549 cells.
Adenocarcinoma of Lung
Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma.
Adenoma
NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.
Adenoma
NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling.
Adenoviridae Infections
CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys.
Amyotrophic Lateral Sclerosis
Regionally different immunoreactivity for Smurf2 and pSmad2/3 in TDP-43-positive inclusions of amyotrophic lateral sclerosis.
Anemia, Sickle Cell
PPAR? increases HUWE1 to attenuate NF-?B/p65 and sickle cell disease with pulmonary hypertension.
Aneurysm
Salvia miltiorrhiza-Derived Sal-miR-58 Induces Autophagy and Attenuates Inflammation in Vascular Smooth Muscle Cells.
Angelman Syndrome
A placebo-controlled trial of folic acid and betaine in identical twins with Angelman syndrome.
Angelman Syndrome
Administration of CoQ10 analogue ameliorates dysfunction of the mitochondrial respiratory chain in a mouse model of Angelman syndrome.
Angelman Syndrome
Cognitive and adaptive behavior profiles of children with Angelman syndrome.
Angelman Syndrome
De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome.
Angelman Syndrome
Denaturing high-performance liquid chromatography for the detection of mutations and polymorphisms in UBE3A.
Angelman Syndrome
E3 Ubiquitin Ligases in Neurological Diseases: Focus on Gigaxonin and Autophagy.
Angelman Syndrome
Genomic organization of the UBE3A/E6-AP gene and related pseudogenes.
Angelman Syndrome
Human disorders of ubiquitination and proteasomal degradation.
Angelman Syndrome
LRSAM1 E3 ubiquitin ligase promotes proteasomal clearance of E6-AP protein.
Angelman Syndrome
Molecular Evolution, Neurodevelopmental Roles and Clinical Significance of HECT-Type UBE3 E3 Ubiquitin Ligases.
Angelman Syndrome
Multiple regions of E6AP (UBE3A) contribute to interaction with papillomavirus E6 proteins and the activation of ubiquitin ligase activity.
Angelman Syndrome
Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.
Angelman Syndrome
Mutation screening of the UBE3A/E6-AP gene in autistic disorder.
Angelman Syndrome
Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome.
Angelman Syndrome
The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily.
Angelman Syndrome
The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/?-catenin pathway by inhibiting the proteasome.
Angelman Syndrome
The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region.
Angelman Syndrome
The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by differential splicing.
Angelman Syndrome
The Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins.
Angelman Syndrome
UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27.
Anhedonia
Nedd4l downregulation of NRG1 in the mPFC induces depression-like behaviour in CSDS mice.
Appendicitis
Association Between NEDD4L Variation and the Genetic Risk of Acute Appendicitis: A Multi-institutional Genome-Wide Association Study.
Appendicitis
NEDD4L Polymorphism and Acute Appendicitis and the Need for a Deeper Dive.
Arrhythmias, Cardiac
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Asthma
Association analysis of UBE3C polymorphisms in Korean aspirin-intolerant asthmatic patients.
Asthma
UBE3C genetic variations as potent markers of nasal polyps in Korean asthma patients.
Asthma
Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma.
Ataxia Telangiectasia
Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response.
Ataxia Telangiectasia
Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation.
Atherosclerosis
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Atherosclerosis
Nedd4 Deficiency in Vascular Smooth Muscle Promotes Vascular Calcification by Stabilizing pSmad1.
Atrial Fibrillation
Identification of Co-expressed Genes Between Atrial Fibrillation and Stroke.
Bacterial Infections
HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection.
Bacterial Infections
HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection.
Bacterial Infections
The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.
Bone Diseases
Value of Osteoblast-Derived Exosomes in Bone Diseases.
Bone Diseases, Metabolic
Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation.
Bone Resorption
PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking.
Brain Ischemia
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.
Brain Ischemia
Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke.
Brain Ischemia
Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion.
Brain Neoplasms
The N-Myc-DLL3 Cascade Is Suppressed by the Ubiquitin Ligase Huwe1 to Inhibit Proliferation and Promote Neurogenesis in the Developing Brain.
Brain Neoplasms
Ubiquitination by HUWE1 in tumorigenesis and beyond.
Breast Neoplasms
A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1.
Breast Neoplasms
A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.
Breast Neoplasms
Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer.
Breast Neoplasms
Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p.
Breast Neoplasms
Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer.
Breast Neoplasms
Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner.
Breast Neoplasms
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.
Breast Neoplasms
Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.
Breast Neoplasms
ER re-expression and re-sensitization to endocrine therapies in ER-negative breast cancers.
Breast Neoplasms
HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.
Breast Neoplasms
Identification of a new natural biflavonoids against breast cancer cells induced ferroptosis via the mitochondrial pathway.
Breast Neoplasms
Inverse association between MDM2 and HUWE1 protein expression levels in human breast cancer and liposarcoma.
Breast Neoplasms
Isoform-specific degradation of PR-B by E6-AP is critical for normal mammary gland development.
Breast Neoplasms
Liganded ER? Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation.
Breast Neoplasms
Metastatic heterogeneity of breast cancer cells is associated with expression of a heterogeneous TGF?-activating miR424-503 gene cluster.
Breast Neoplasms
MiR-153 promotes breast cancer cell apoptosis by targeting HECTD3.
Breast Neoplasms
NEDD4 expression is associated with breast cancer progression and is predictive of a poor prognosis.
Breast Neoplasms
NEDD4 Family of E3 Ubiquitin Ligases in Breast Cancer: Spotlight on SMURFs, WWPs and NEDD4.
Breast Neoplasms
NEDD4 Plays Roles in the Maintenance of Breast Cancer Stem Cell Characteristics.
Breast Neoplasms
NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase ? and its implication in breast cancer cell proliferation.
Breast Neoplasms
Oncogenic function of p34SEI-1 via NEDD4?1?mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway.
Breast Neoplasms
Oncogenic UBE3C promotes breast cancer progression by activating Wnt/?-catenin signaling.
Breast Neoplasms
Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary tumorigenesis.
Breast Neoplasms
PRRG4 promotes breast cancer metastasis through the recruitment of NEDD4 and downregulation of Robo1.
Breast Neoplasms
PTEN and NEDD4 in Human Breast Carcinoma.
Breast Neoplasms
Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression.
Breast Neoplasms
Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness.
Breast Neoplasms
SMURF1 facilitates estrogen receptor ? signaling in breast cancer cells.
Breast Neoplasms
SMURF1 plays a role in EGF-induced breast cancer cell migration and invasion.
Breast Neoplasms
Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner.
Breast Neoplasms
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.
Breast Neoplasms
SND1 acts downstream of TGF?1 and upstream of Smurf1 to promote breast cancer metastasis.
Breast Neoplasms
The expression and clinical significance of HERC4 in breast cancer.
Breast Neoplasms
The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8.
Breast Neoplasms
The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L.
Breast Neoplasms
The Nedd4-like family of E3 ubiquitin ligases and cancer.
Breast Neoplasms
The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2.
Breast Neoplasms
The PIAS3-Smurf2 sumoylation pathway suppresses breast cancer organoid invasiveness.
Breast Neoplasms
The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.
Breast Neoplasms
Transcriptome-wide analysis and modelling of prognostic alternative splicing signatures in invasive breast cancer: a prospective clinical study.
Breast Neoplasms
USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.
Breast Neoplasms
[Expression of E3 ligase HERC4 in breast cancer and its clinical implications].
Brucellosis
Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2.
Carcinogenesis
A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.
Carcinogenesis
A conformational switch regulates the ubiquitin ligase HUWE1.
Carcinogenesis
A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication.
Carcinogenesis
A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1.
Carcinogenesis
A Variant Smurf2 Protects Mice Against Colitis-Associated Colon Cancer by Inducing Transforming Growth Factor ? Signaling.
Carcinogenesis
Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer.
Carcinogenesis
ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance.
Carcinogenesis
Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2.
Carcinogenesis
Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner.
Carcinogenesis
Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p.
Carcinogenesis
CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.
Carcinogenesis
Decreased expression of e6-associated protein in breast and prostate carcinomas.
Carcinogenesis
DNA methylation-mediated downregulation of PTPN3 attenuates to boost TGF-? signaling in osteosarcoma cells.
Carcinogenesis
Downregulation of Nedd4L predicts poor prognosis, promotes tumor growth and inhibits MAPK/ERK signal pathway in hepatocellular carcinoma.
Carcinogenesis
Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response.
Carcinogenesis
FOSL1 promotes tumorigenesis in colorectal carcinoma by mediating the FBXL2/Wnt/?-catenin axis via Smurf1.
Carcinogenesis
Generation of Smurf2 Conditional Knockout Mice.
Carcinogenesis
Generation of SMURF2 knockout human cells using the CRISPR/Cas9 system.
Carcinogenesis
H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis.
Carcinogenesis
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Carcinogenesis
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53.
Carcinogenesis
IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way.
Carcinogenesis
Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?
Carcinogenesis
Low density lipoprotein receptor class A domain containing 4 (LDLRAD4) promotes tumorigenesis of hepatic cancer cells.
Carcinogenesis
Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer.
Carcinogenesis
MicroRNA-125a inhibits tumorigenesis by targeting Smurf1 in colorectal carcinoma.
Carcinogenesis
MiR-542-5p is a negative prognostic factor and promotes osteosarcoma tumorigenesis by targeting HUWE1.
Carcinogenesis
miR-93 promotes TGF-?-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells.
Carcinogenesis
NEDD4 E3 ligase: Functions and mechanism in human cancer.
Carcinogenesis
NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation.
Carcinogenesis
Nedd4, a human ubiquitin ligase, affects actin cytoskeleton in yeast cells.
Carcinogenesis
Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer.
Carcinogenesis
Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer.
Carcinogenesis
Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor-Suppressive Interaction with Smurf2.
Carcinogenesis
Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary tumorigenesis.
Carcinogenesis
Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
Carcinogenesis
Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas.
Carcinogenesis
RNF43 interacts with NEDL1 and regulates p53-mediated transcription.
Carcinogenesis
SCF?-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway.
Carcinogenesis
Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.
Carcinogenesis
Smurf1 controls S phase progression and tumorigenesis through Wee1 degradation.
Carcinogenesis
Smurf1 regulation of DAB2IP controls cell proliferation and migration.
Carcinogenesis
Smurf1-positive expression indicates favorable survival for resected non-small cell lung cancer patients.
Carcinogenesis
Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis.
Carcinogenesis
SMURF2 prevents detrimental changes to chromatin, protecting human dermal fibroblasts from chromosomal instability and tumorigenesis.
Carcinogenesis
Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.
Carcinogenesis
Structure of the HECT domain of human WWP2.
Carcinogenesis
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
Carcinogenesis
The dual function steroid receptor coactivator/ubiquitin protein-ligase integrator E6-AP is overexpressed in mouse mammary tumorigenesis.
Carcinogenesis
The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer.
Carcinogenesis
The Emerging Roles of the HERC Ubiquitin Ligases in Cancer.
Carcinogenesis
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
Carcinogenesis
The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase.
Carcinogenesis
Transcription alterations of members of the ubiquitin-proteasome network in prostate carcinoma.
Carcinogenesis
Ubiquitin ligase E6-AP and its role in human disease.
Carcinogenesis
Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.
Carcinogenesis
Ubiquitination by HUWE1 in tumorigenesis and beyond.
Carcinogenesis
Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
Carcinogenesis
USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.
Carcinogenesis
[Expression of E3 ligase HERC4 in breast cancer and its clinical implications].
Carcinoma
Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer.
Carcinoma
Decreased expression of e6-associated protein in breast and prostate carcinomas.
Carcinoma
Deletion of SMURF 1 represses ovarian cancer invasion and EMT by modulating the DAB2IP/AKT/Skp2 feedback loop.
Carcinoma
Enhanced immortalization, HUWE1 mutations and other biological drivers of breast invasive carcinoma in Black/African American patients.
Carcinoma
Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas.
Carcinoma
HERC4 Is Overexpressed in Hepatocellular Carcinoma and Contributes to the Proliferation and Migration of Hepatocellular Carcinoma Cells.
Carcinoma
High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma.
Carcinoma
HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.
Carcinoma
Involvement of general control nonderepressible kinase 2 in cancer cell apoptosis by posttranslational mechanisms.
Carcinoma
Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?
Carcinoma
Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy.
Carcinoma
Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas.
Carcinoma
Pan-cancer Analysis of NEDD4L and Its Tumor Suppressor Effects in Clear Cell Renal Cell Carcinoma.
Carcinoma
PTEN and NEDD4 in Human Breast Carcinoma.
Carcinoma
Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression.
Carcinoma
SMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma.
Carcinoma
SMURF1, a promoter of tumor cell progression?
Carcinoma
Suppression of human tumor cell proliferation by Smurf2-induced senescence.
Carcinoma
The E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation.
Carcinoma
The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions.
Carcinoma
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
Carcinoma
The Nedd4-like family of E3 ubiquitin ligases and cancer.
Carcinoma
UBE3C Promotes Growth and Metastasis of Renal Cell Carcinoma via Activating Wnt/?-Catenin Pathway.
Carcinoma
Ubiquitin ligase SMURF1 functions as a prognostic marker and promotes growth and metastasis of clear cell renal cell carcinoma.
Carcinoma
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.
Carcinoma
Upregulation of microRNA?194?5p inhibits hypopharyngeal carcinoma cell proliferation, migration and invasion by targeting SMURF1 via the mTOR signaling pathway.
Carcinoma
Whole-exome sequencing identifies mutated PCK2 and HUWE1 associated with carcinoma cell proliferation in a hepatocellular carcinoma patient.
Carcinoma, Basal Cell
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.
Carcinoma, Ductal
Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression.
Carcinoma, Hepatocellular
CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and ?TrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
CUL4B, NEDD4, and UGT1As involve in the TGF-? signalling in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Downregulation of Nedd4L predicts poor prognosis, promotes tumor growth and inhibits MAPK/ERK signal pathway in hepatocellular carcinoma.
Carcinoma, Hepatocellular
HERC4 Is Overexpressed in Hepatocellular Carcinoma and Contributes to the Proliferation and Migration of Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
MiR-542-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting UBE3C.
Carcinoma, Hepatocellular
NEDD4 Depletion Inhibits Hepatocellular Carcinoma Growth via Targeting PTEN.
Carcinoma, Hepatocellular
NEDD4 Induces K48-Linked Degradative Ubiquitination of Hepatitis B Virus X Protein and Inhibits HBV-Associated HCC Progression.
Carcinoma, Hepatocellular
NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma.
Carcinoma, Hepatocellular
NEDD4 promotes cell growth and motility in hepatocellular carcinoma.
Carcinoma, Hepatocellular
The ménage à trois of autophagy, lipid droplets and liver disease.
Carcinoma, Hepatocellular
Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth.
Carcinoma, Hepatocellular
Whole-exome sequencing identifies mutated PCK2 and HUWE1 associated with carcinoma cell proliferation in a hepatocellular carcinoma patient.
Carcinoma, Hepatocellular
CUL4B, NEDD4, and UGT1As involve in the TGF-? signalling in hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
Decreased expression of NEDD4L contributes to NSCLC progression and metastasis.
Carcinoma, Non-Small-Cell Lung
Erratum to: Identification of the NEDD4L Gene as a Prognostic Marker by Integrated Microarray Analysis of Copy Number and Gene Expression Profiling in Non-small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53.
Carcinoma, Non-Small-Cell Lung
Identification of the NEDD4L Gene as a Prognostic Marker by Integrated Microarray Analysis of Copy Number and Gene Expression Profiling in Non-small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.
Carcinoma, Non-Small-Cell Lung
Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas.
Carcinoma, Non-Small-Cell Lung
Smurf1-positive expression indicates favorable survival for resected non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
Carcinoma, Ovarian Epithelial
Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue.
Carcinoma, Renal Cell
Integrated bioinformatics analysis of the NEDD4 family reveals a prognostic value of NEDD4L in clear-cell renal cell cancer.
Carcinoma, Renal Cell
Pan-cancer Analysis of NEDD4L and Its Tumor Suppressor Effects in Clear Cell Renal Cell Carcinoma.
Carcinoma, Renal Cell
SMURF1, a promoter of tumor cell progression?
Carcinoma, Renal Cell
UBE3C Promotes Growth and Metastasis of Renal Cell Carcinoma via Activating Wnt/?-Catenin Pathway.
Carcinoma, Renal Cell
Ubiquitin ligase SMURF1 functions as a prognostic marker and promotes growth and metastasis of clear cell renal cell carcinoma.
Carcinoma, Squamous Cell
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53.
Carcinoma, Squamous Cell
SMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.
Cardiomegaly
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Cardiomegaly
HECT (Homologous to the E6-AP Carboxyl Terminus)-Type Ubiquitin E3 Ligase ITCH Attenuates Cardiac Hypertrophy by Suppressing the Wnt/?-Catenin Signaling Pathway.
Cardiomegaly
The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice.
Cardiomyopathy, Dilated
Genomic analysis of an infant with intractable diarrhea and dilated cardiomyopathy.
Cardiotoxicity
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Cardiotoxicity
HECT-Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin-Interacting Protein and Ameliorates Reactive Oxygen Species-Induced Cardiotoxicity.
Cardiovascular Diseases
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Cardiovascular Diseases
Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death.
Cerebral Infarction
Smurf2 exerts neuroprotective effects on cerebral ischemic injury.
Cervical Intraepithelial Neoplasia
Detection of E6-AP as a potential therapeutic target in cervical specimen of HPV-infected women.
Charcot-Marie-Tooth Disease
SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease.
Charcot-Marie-Tooth Disease
SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation.
Cleft Palate
A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.
Cleft Palate
Author Correction: A missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria, and cleft palate.
Cleft Palate
Familial NEDD4L variant in periventricular nodular heterotopia and in a fetus with hypokinesia and flexion contractures.
Cleft Palate
Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.
Cleft Palate
Recurrent NEDD4L Variant in Periventricular Nodular Heterotopia, Polymicrogyria and Syndactyly.
Cockayne Syndrome
Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.
Colitis, Ulcerative
Emerging views of mitophagy in immunity and autoimmune diseases.
Colitis-Associated Neoplasms
A Variant Smurf2 Protects Mice Against Colitis-Associated Colon Cancer by Inducing Transforming Growth Factor ? Signaling.
Colonic Neoplasms
CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.
Colonic Neoplasms
IRAK2 counterbalances oncogenic Smurf1 in colon cancer cells by dictating ER stress.
Colonic Neoplasms
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.
Colonic Neoplasms
NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation.
Colonic Neoplasms
Reversible regulation of SATB1 ubiquitination by USP47 and SMURF2 mediates colon cancer cell proliferation and tumor progression.
Colonic Neoplasms
Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation.
Colonic Neoplasms
SMURF1, a promoter of tumor cell progression?
Colorectal Neoplasms
E3 ubiquitin ligase SMURF2 prevents colorectal cancer by reducing the stability of the YY1 protein and inhibiting the SENP1/c-myc axis.
Colorectal Neoplasms
E3 ubiquitin ligase Smurf2: a prognostic factor in microsatellite stable colorectal cancer.
Colorectal Neoplasms
Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas.
Colorectal Neoplasms
FOSL1 promotes tumorigenesis in colorectal carcinoma by mediating the FBXL2/Wnt/?-catenin axis via Smurf1.
Colorectal Neoplasms
Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.
Colorectal Neoplasms
HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.
Colorectal Neoplasms
Intestinal knockout of Nedd4 enhances growth of Apc(min) tumors.
Colorectal Neoplasms
IRAK2 counterbalances oncogenic Smurf1 in colon cancer cells by dictating ER stress.
Colorectal Neoplasms
Low Expression of Smurf1 Enhances the Chemosensitivity of Human Colorectal Cancer to Gemcitabine and Cisplatin in Patient-Derived Xenograft Models.
Colorectal Neoplasms
Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer.
Colorectal Neoplasms
MicroRNA-125a inhibits tumorigenesis by targeting Smurf1 in colorectal carcinoma.
Colorectal Neoplasms
Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy.
Colorectal Neoplasms
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.
Colorectal Neoplasms
NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling.
Colorectal Neoplasms
STK35 Is Ubiquitinated by NEDD4L and Promotes Glycolysis and Inhibits Apoptosis Through Regulating the AKT Signaling Pathway, Influencing Chemoresistance of Colorectal Cancer.
Colorectal Neoplasms
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
Colorectal Neoplasms
The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation.
Colorectal Neoplasms
Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.
Colorectal Neoplasms
Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
Contracture
Familial NEDD4L variant in periventricular nodular heterotopia and in a fetus with hypokinesia and flexion contractures.
COVID-19
Inhibition of HECT E3 ligases as potential therapy for COVID-19.
Crohn Disease
Emerging views of mitophagy in immunity and autoimmune diseases.
Cystic Fibrosis
Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease.
Cystic Fibrosis
Role of the ubiquitin system in regulating ion transport.
Cystic Fibrosis
The Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins.
Deafness
Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes.
Dehydration
Alpha Enolase 1 Ubiquitination and Degradation Mediated by Ehrlichia chaffeensis TRP120 Disrupts Glycolytic Flux and Promotes Infection.
Dehydration
Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease.
Diabetes Mellitus, Type 2
Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome.
Diabetic Nephropathies
Association of UBE3C Variants with Reduced Kidney Function in Patients with Diabetic Kidney Disease.
Diabetic Nephropathies
Diminution of microRNA-98 alleviates renal fibrosis in diabetic nephropathy by elevating Nedd4L and inactivating TGF-?/Smad2/3 pathway.
Diabetic Nephropathies
Molecular mechanism of smurf2 in regulating the expression of SnoN in diabetic nephropathy.
Dyslexia
Genetic risk variants for dyslexia on chromosome 18 in a German cohort.
Ehrlichiosis
Alpha Enolase 1 Ubiquitination and Degradation Mediated by Ehrlichia chaffeensis TRP120 Disrupts Glycolytic Flux and Promotes Infection.
Ehrlichiosis
Ehrlichia chaffeensis TRP120 Binds a G+C-Rich Motif in Host Cell DNA and Exhibits Eukaryotic Transciptional Activator Function.
Ehrlichiosis
Molecular basis of antibody mediated immunity against Ehrlichia chaffeensis involves species-specific linear epitopes in tandem repeat proteins.
Encephalitis, Japanese
E3 Ubiquitin Ligase Nedd4 Promotes Japanese Encephalitis Virus Replication by Suppressing Autophagy in Human Neuroblastoma Cells.
Encephalitis, Japanese
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Encephalomyelitis
Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.
Encephalomyelitis, Autoimmune, Experimental
Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.
Endometrial Neoplasms
NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling.
Endometrial Neoplasms
Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer.
Endometriosis
SMURF1-mediated ubiquitylation of SHP-1 promotes cell proliferation and invasion of endometrial stromal cells in endometriosis.
Epilepsy
De novo 2q36.3q37.1 deletion encompassing TRIP12 and NPPC yields distinct phenotypes.
Epilepsy
Genetic diagnoses in epilepsy: The impact of dynamic exome analysis in a pediatric cohort.
Epilepsy
Novel de novo TRIP12 mutation reveals variable phenotypic presentation while emphasizing core features of TRIP12 variations.
Esophageal Squamous Cell Carcinoma
High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
The E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation.
Esophageal Squamous Cell Carcinoma
The Nedd4-like family of E3 ubiquitin ligases and cancer.
Essential Hypertension
?-Kinase 2 is a novel candidate gene for inherited hypertension in Dahl rats.
Essential Hypertension
Association of NEDD4L ubiquitin ligase with essential hypertension.
Essential Hypertension
Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript.
Essential Hypertension
Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension.
Essential Hypertension
Gender difference in association of NEDD4L gene variants among southern Han Chinese with essential hypertension - a population-based case-control study.
Essential Hypertension
Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study.
Essential Hypertension
NEDD4L in essential hypertension.
Essential Hypertension
Two polymorphisms in NEDD4L gene and essential hypertension in Chinese Hans - a population-based case-control study.
Fatty Liver
Increase of E3 ubiquitin ligase NEDD4 expression leads to degradation of its target proteins PTEN/IGF1R during the formation of goose fatty liver.
Fatty Liver
Protective Effect of SMAD-Specific E3 Ubiquitin Protein Ligase 1 in Alcoholic Steatohepatitis in Mice.
Fatty Liver
Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner.
Fatty Liver
The ménage à trois of autophagy, lipid droplets and liver disease.
Fatty Liver, Alcoholic
Protective Effect of SMAD-Specific E3 Ubiquitin Protein Ligase 1 in Alcoholic Steatohepatitis in Mice.
Fibroadenoma
Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression.
Frontotemporal Dementia
VCP/p97 increases BMP signaling by accelerating ubiquitin ligase Smurf1 degradation.
Gallbladder Neoplasms
Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer.
Glioblastoma
A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis.
Glioblastoma
Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation.
Glioblastoma
SMURF1, a promoter of tumor cell progression?
Glioma
Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells.
Glioma
Down-regulation of Nedd4L is Associated with the Aggressive Progression and Worse Prognosis of Malignant Glioma.
Glioma
IGF-1-enhanced miR-513a-5p signaling desensitizes glioma cells to temozolomide by targeting the NEDD4L-inhibited Wnt/?-catenin pathway.
Glioma
NEDD4-1 regulates migration and invasion of glioma cells through CNrasGEF ubiquitination in vitro.
Glioma
Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain.
Glioma
Regulation of glioma migration and invasion via modification of Rap2a activity by the ubiquitin ligase Nedd4-1.
Glioma
Suppression of the Smurf1 Expression Inhibits Tumor Progression in Gliomas.
Glioma
The N-Myc-DLL3 Cascade Is Suppressed by the Ubiquitin Ligase Huwe1 to Inhibit Proliferation and Promote Neurogenesis in the Developing Brain.
Glioma
Ubiquitin-protein ligase E3C promotes glioma progression by mediating the ubiquitination and degrading of Annexin A7.
Glioma
Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy.
Gram-Negative Bacterial Infections
E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation.
Hearing Loss
De novo 2q36.3q37.1 deletion encompassing TRIP12 and NPPC yields distinct phenotypes.
Heart Diseases
Microarray analysis and functional characterization revealed NEDD4-mediated cardiomyocyte autophagy induced by angiotensin II.
Heart Diseases
The Role of HECT-Type E3 Ligase in the Development of Cardiac Disease.
Heart Failure
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Heart Valve Diseases
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
hect-type e3 ubiquitin transferase deficiency
E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3.
hect-type e3 ubiquitin transferase deficiency
E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity.
hect-type e3 ubiquitin transferase deficiency
E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation.
hect-type e3 ubiquitin transferase deficiency
Generation of Smurf2 Conditional Knockout Mice.
hect-type e3 ubiquitin transferase deficiency
Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3-H19 Cascade.
hect-type e3 ubiquitin transferase deficiency
Nedd4 Deficiency in Vascular Smooth Muscle Promotes Vascular Calcification by Stabilizing pSmad1.
hect-type e3 ubiquitin transferase deficiency
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.
hect-type e3 ubiquitin transferase deficiency
Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes.
hect-type e3 ubiquitin transferase deficiency
Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.
hect-type e3 ubiquitin transferase deficiency
Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1.
Hemangioma, Cavernous, Central Nervous System
Cerebral Cavernous Malformation 2 Protein Promotes Smad Ubiquitin Regulatory Factor 1-mediated RhoA Degradation in Endothelial Cells.
Hepatitis B
Functional characterization of the putative hepatitis B virus core protein late domain using retrovirus chimeras.
Hepatitis B
NEDD4 Induces K48-Linked Degradative Ubiquitination of Hepatitis B Virus X Protein and Inhibits HBV-Associated HCC Progression.
Hepatitis B
{gamma}2-Adaptin, a Novel Ubiquitin-interacting Adaptor, and Nedd4 Ubiquitin Ligase Control Hepatitis B Virus Maturation.
Hepatitis C
Hepatitis C virus/human interactome identifies SMURF2 and the viral protease as critical elements for the control of TGF-? signaling.
Hepatitis, Alcoholic
Protective Effect of SMAD-Specific E3 Ubiquitin Protein Ligase 1 in Alcoholic Steatohepatitis in Mice.
Herpes Simplex
Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions.
Herpes Simplex
Herpes simplex virus type 2 UL56 interacts with the ubiquitin ligase Nedd4 and increases its ubiquitination.
Herpes Simplex
Herpesviruses possess conserved proteins for interaction with Nedd4 family ubiquitin E3 ligases.
Herpes Simplex
Image-based genome-wide siRNA screen identifies selective autophagy factors.
Hyperaldosteronism
High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension.
Hypersensitivity
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability.
Hypertension
A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension.
Hypertension
A functional variant of NEDD4L is associated with obesity and related phenotypes in a Han population of Southern China.
Hypertension
A variant in the NEDD4L gene associates with hypertension in chronic kidney disease in the southeastern Han Chinese population.
Hypertension
Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.
Hypertension
DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.
Hypertension
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Hypertension
Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface.
Hypertension
Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension.
Hypertension
Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: the Hypertension Genetic Epidemiology Network (HyperGEN) Study.
Hypertension
Gender difference in association of NEDD4L gene variants among southern Han Chinese with essential hypertension - a population-based case-control study.
Hypertension
Genetic variation and association analyses of NEDD4 gene in Kazak Chinese patients with hypertension.
Hypertension
Genetic variation in NEDD4L, salt sensitivity, and hypertension: human NEDD4L rs4149601 G allele generates evolutionary new isoform I with C2 domain.
Hypertension
Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study.
Hypertension
Genetic variations in the sodium balance-regulating genes ENaC, NEDD4L, NDFIP2 and USP2 influence blood pressure and hypertension.
Hypertension
Inhibition of the epithelial Na+ channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome.
Hypertension
MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.
Hypertension
MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1.
Hypertension
Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4.
Hypertension
Novel SNPs of WNK1 and AKR1C3 are associated with preeclampsia.
Hypertension
Polymorphism in NEDD4L is associated with increased salt sensitivity, reduced levels of P-renin and increased levels of Nt-proANP.
Hypertension
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension.
Hypertension
Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension.
Hypertension
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels.
Hypertension
Transcriptional diversity and expression of NEDD4L gene in distal nephron.
Hypertension
Two polymorphisms in NEDD4L gene and essential hypertension in Chinese Hans - a population-based case-control study.
Hypertension, Pulmonary
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Hypertension, Pulmonary
PPAR? increases HUWE1 to attenuate NF-?B/p65 and sickle cell disease with pulmonary hypertension.
Hypertrophy, Right Ventricular
MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1.
Hypokinesia
Familial NEDD4L variant in periventricular nodular heterotopia and in a fetus with hypokinesia and flexion contractures.
Hypospadias
Downregulation of MicroRNA-494 inhibits the TGF-?1/Smads signaling pathway and prevents the development of hypospadias through upregulating Nedd4L.
Hypotension, Orthostatic
A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension.
Hypotension, Orthostatic
Association of NEDD4L ubiquitin ligase with essential hypertension.
Infarction, Middle Cerebral Artery
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.
Infections
A capsid-encoded PPxY-motif facilitates adenovirus entry.
Infections
Alpha Enolase 1 Ubiquitination and Degradation Mediated by Ehrlichia chaffeensis TRP120 Disrupts Glycolytic Flux and Promotes Infection.
Infections
BEI Inactivated Vaccine Induces Innate and Adaptive Responses and Elicits Partial Protection upon Reassortant Betanodavirus Infection in Senegalese Sole.
Infections
DDIT3 Targets Innate Immunity via the DDIT3-OTUD1-MAVS Pathway To Promote Bovine Viral Diarrhea Virus Replication.
Infections
E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3.
Infections
E3 Ubiquitin Ligase Nedd4 Promotes Japanese Encephalitis Virus Replication by Suppressing Autophagy in Human Neuroblastoma Cells.
Infections
Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection.
Infections
Ehrlichia chaffeensis TRP120 Activates Canonical Notch Signaling To Downregulate TLR2/4 Expression and Promote Intracellular Survival.
Infections
Ehrlichia chaffeensis TRP120 Binds a G+C-Rich Motif in Host Cell DNA and Exhibits Eukaryotic Transciptional Activator Function.
Infections
Ehrlichia chaffeensis TRP120 Effector Targets and Recruits Host Polycomb Group Proteins for Degradation To Promote Intracellular Infection.
Infections
Ehrlichia chaffeensis TRP120 Moonlights as a HECT E3 Ligase Involved in Self- and Host Ubiquitination To Influence Protein Interactions and Stability for Intracellular Survival.
Infections
Ehrlichia chaffeensis TRP120-mediated ubiquitination and proteasomal degradation of tumor suppressor FBW7 increases oncoprotein stability and promotes infection.
Infections
HECT E3 Ubiquitin Ligase Nedd4 Is Required for Antifungal Innate Immunity.
Infections
HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection.
Infections
Huwe1, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity.
Infections
Identifying potential drug targets and candidate drugs for COVID-19: biological networks and structural modeling approaches.
Infections
Molecular basis of antibody mediated immunity against Ehrlichia chaffeensis involves species-specific linear epitopes in tandem repeat proteins.
Infections
NEDD4 Induces K48-Linked Degradative Ubiquitination of Hepatitis B Virus X Protein and Inhibits HBV-Associated HCC Progression.
Infections
Nedd4-Mediated Increase in HIV-1 Gag and Env Proteins and Immunity following DNA-Vaccination of BALB/c Mice.
Infections
Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication.
Infections
Smurf2 alters BPV1 trafficking and decreases infection.
Infections
Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.
Infections
The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice.
Infections
The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members.
Infections
The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.
Infertility, Female
X-Linked Huwe1 Is Essential for Oocyte Maturation and Preimplantation Embryo Development.
Inflammatory Bowel Diseases
Emerging views of mitophagy in immunity and autoimmune diseases.
Influenza, Human
E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3.
Influenza, Human
Human microRNA-30 inhibits influenza virus infection by suppressing the expression of SOCS1, SOCS3, and NEDD4.
Insulin Resistance
Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome.
Insulin Resistance
Nedd4 Haploinsufficient Mice Display Moderate Insulin Resistance, Enhanced Lipolysis, and Protection against High-fat Diet Induced Obesity.
Intellectual Disability
Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE.
Intellectual Disability
Case Report: Whole Exome Sequencing Revealed Disease-Causing Variants in Two Genes in a Patient With Autism Spectrum Disorder, Intellectual Disability, Hyperactivity, Sleep and Gastrointestinal Disturbances.
Intellectual Disability
Copy-Number Gains of HUWE1 Due to Replication- and Recombination-Based Rearrangements.
Intellectual Disability
De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability.
Intellectual Disability
Erratum to: Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.
Intellectual Disability
Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.
Intellectual Disability
HUWE1 mutation explains phenotypic severity in a case of familial idiopathic intellectual disability.
Intellectual Disability
HUWE1 variants cause dominant X-linked intellectual disability: a clinical study of 21 patients.
Intellectual Disability
Identification of new TRIP12 variants and detailed clinical evaluation of individuals with non-syndromic intellectual disability with or without autism.
Intellectual Disability
Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities.
Intellectual Disability
Novel microduplications at Xp11.22 including HUWE1: clinical and molecular insights into these genomic rearrangements associated with intellectual disability.
Intellectual Disability
Regulation of turnover of tumor suppressor p53 and cell growth by E6-AP, a ubiquitin protein ligase mutated in Angelman mental retardation syndrome.
Intellectual Disability
Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease.
Intellectual Disability
Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with mental retardation.
Intellectual Disability
The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily.
Intellectual Disability
The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development.
Intellectual Disability
Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/?-catenin pathway in a Drosophila model for intellectual disability.
Intellectual Disability
Xp11.22 Microduplications Including HUWE1: Case Report and Literature Review.
Intellectual Disability
[Intellectual disability due to heterozygous c.40C>T variant of TRIP12 gene in a patient].
Intervertebral Disc Degeneration
Ectopic expression of Smurf2 and acceleration of age-related intervertebral disc degeneration in a mouse model.
Intervertebral Disc Degeneration
TGF-? Initiates ?-Catenin-Mediated CTGF Secretory Pathway in Old Bovine Nucleus Pulposus Cells: A Potential Mechanism for Intervertebral Disc Degeneration.
Ischemic Stroke
Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity.
Ischemic Stroke
Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke.
Keloid
A Role for the E3 Ubiquitin Ligase NEDD4 in Keloid Pathogenesis.
Keloid
Admixture mapping identifies a locus at 15q21.2-22.3 associated with keloid formation in African Americans.
Keloid
Association study confirmed susceptibility loci with keloid in the Chinese Han population.
Keloid
NEDD4 Is Involved in Inflammation Development during Keloid Formation.
Keloid
NEDD4 single nucleotide polymorphism rs2271289 is associated with keloids in Chinese Han population.
Keloid
NEDD4-1 and PTEN expression in keloid scarring.
Keloid
Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 (NEDD4) Gene Polymorphism Contributes to Keloid Development in Egyptian Population.
Keloid
Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production.
Keloid
STAT3 operates as a novel transcription factor that regulates NEDD4 in Keloid.
Keloid
The Ubiquitin Proteasome System and Skin Fibrosis.
Language Development Disorders
Erratum to: Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.
Language Development Disorders
Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.
Language Development Disorders
Novel de novo TRIP12 mutation reveals variable phenotypic presentation while emphasizing core features of TRIP12 variations.
Learning Disabilities
Identification of new TRIP12 variants and detailed clinical evaluation of individuals with non-syndromic intellectual disability with or without autism.
Leukemia
HUWE1 cooperates with RAS activation to control leukemia cell proliferation and human hematopoietic stem cells differentiation fate.
Leukemia
Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding.
Leukemia, Myeloid
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.
Leukemia, Myeloid, Acute
RNA-Seq analysis identifies aberrant RNA splicing of TRIP12 in acute myeloid leukemia patients at remission.
Leukemia, T-Cell
PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101 [corrected].
Leukemia, T-Cell
Regulation of human T-cell leukemia virus type 1 (HTLV-1) budding by ubiquitin ligase Nedd4.
Liddle Syndrome
Solution structure of a Nedd4 WW domain-ENaC peptide complex.
Liposarcoma
Inverse association between MDM2 and HUWE1 protein expression levels in human breast cancer and liposarcoma.
Listeriosis
The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.
Liver Cirrhosis
Abnormal expression of Smurf2 during the process of rat liver fibrosis.
Liver Cirrhosis
Smad ubiquitination regulatory factor 2 expression is enhanced in hypertrophic scar fibroblasts from burned children.
Liver Cirrhosis
Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition.
Liver Cirrhosis, Biliary
Emerging views of mitophagy in immunity and autoimmune diseases.
Liver Diseases
Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner.
Liver Diseases
The ménage à trois of autophagy, lipid droplets and liver disease.
Liver Failure
Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration.
Liver Neoplasms
Impaired phosphorylation and ubiquitination by P70 S6 kinase (P70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promotes Tribbles homolog 2 (TRIB2) stability and carcinogenic property in liver cancer.
Liver Neoplasms
NEDD4 promotes cell growth and motility in hepatocellular carcinoma.
Liver Neoplasms
Reciprocal regulation between ?TrCP and Smurf1 suppresses proliferative capacity of liver cancer cells.
Liver Neoplasms
TRIB2 inhibits Wnt/?-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, ?-TrCP, COP1 and Smurf1, in liver cancer cells.
Liver Neoplasms
Ubiquitin E3 ligase SCF(?-TRCP) regulates TRIB2 stability in liver cancer cells.
Liver Neoplasms
[Regulation of Smad ubiquitination regulatory factor 1 expression by NF-?B].
Lung Diseases
Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease.
Lung Diseases
Ubiquitination of heat shock protein 27 is mediated by its interaction with Smad ubiquitination regulatory factor 2 in A549 cells.
Lung Neoplasms
An outlined review for the role of Nedd4-1 and Nedd4-2 in lung disorders.
Lung Neoplasms
Decreased expression of NEDD4L contributes to NSCLC progression and metastasis.
Lung Neoplasms
Erratum to: Identification of the NEDD4L Gene as a Prognostic Marker by Integrated Microarray Analysis of Copy Number and Gene Expression Profiling in Non-small Cell Lung Cancer.
Lung Neoplasms
Exosomes Derived From Macrophages Enhance Aerobic Glycolysis and Chemoresistance in Lung Cancer by Stabilizing c-Myc via the Inhibition of NEDD4L.
Lung Neoplasms
Expression of HERC4 in Lung Cancer and its Correlation with Clinicopathological Parameters.
Lung Neoplasms
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53.
Lung Neoplasms
HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.
Lung Neoplasms
Identification of the NEDD4L Gene as a Prognostic Marker by Integrated Microarray Analysis of Copy Number and Gene Expression Profiling in Non-small Cell Lung Cancer.
Lung Neoplasms
LIMCH1 suppress the growth of lung cancer by interacting with HUWE1 to sustain p53 stability.
Lung Neoplasms
Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer.
Lung Neoplasms
MiR-195 and miR-497 suppress tumorigenesis in lung cancer by inhibiting SMURF2-induced TGF-? receptor I ubiquitination.
Lung Neoplasms
miR-93 promotes TGF-?-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells.
Lung Neoplasms
Nitidine chloride suppresses NEDD4 expression in lung cancer cells.
Lung Neoplasms
Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.
Lung Neoplasms
Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas.
Lung Neoplasms
Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.
Lung Neoplasms
Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKI?.
Lung Neoplasms
Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells.
Lung Neoplasms
Smurf1-positive expression indicates favorable survival for resected non-small cell lung cancer patients.
Lung Neoplasms
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
Lung Neoplasms
The Emerging Roles of the HERC Ubiquitin Ligases in Cancer.
Lung Neoplasms
Ubiquitin ligase SMURF2 enhances epidermal growth factor receptor stability and tyrosine-kinase inhibitor resistance.
Lung Neoplasms
Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.
Lupus Erythematosus, Systemic
Emerging views of mitophagy in immunity and autoimmune diseases.
Lymphatic Metastasis
Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient.
Lymphatic Metastasis
High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma.
Lymphatic Metastasis
NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma.
Lymphatic Metastasis
Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue.
Lymphatic Metastasis
Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma.
Lymphoma
Characterization of ARF-BP1/HUWE1 Interactions with CTCF, MYC, ARF and p53 in MYC-Driven B Cell Neoplasms.
Lymphoma
Knockdown of long noncoding RNA XIST mitigates the apoptosis and inflammatory injury of microglia cells after spinal cord injury through miR-27a/Smurf1 axis.
Lymphoma, B-Cell
Knockdown of long noncoding RNA XIST mitigates the apoptosis and inflammatory injury of microglia cells after spinal cord injury through miR-27a/Smurf1 axis.
Lymphoma, B-Cell
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Lymphoma, B-Cell
Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.
Lymphoma, B-Cell
Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1.
Medulloblastoma
Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors.
Melanoma
Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma.
Melanoma
Emerging views of mitophagy in immunity and autoimmune diseases.
Melanoma
Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells.
Melanoma
NEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma.
Melanoma
NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.
Melanoma
Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma.
Melanoma
Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
Melanoma
The Anti-proliferative Response of Indole-3-carbinol in human melanoma cells is Triggered by an Interaction with NEDD4-1 and Disruption of Wild-type PTEN Degradation.
Melanoma
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.
Melanoma
Ubiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation.
Metabolic Syndrome
Gender flip-flop association between genetic variations of NEDD4L and metabolic syndrome in the Kazakh general population.
Mouth Neoplasms
E3 Ubiquitin Ligases as Molecular Targets in Human Oral Cancers.
Multiple Myeloma
Targeting of the E3 ubiquitin-protein ligase HUWE1 impairs DNA repair capacity and tumor growth in preclinical multiple myeloma models.
Multiple Myeloma
The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma.
Multiple Myeloma
The NEDD4-1 E3 ubiquitin ligase: A potential molecular target for bortezomib sensitivity in multiple myeloma.
Multiple Myeloma
The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.
Multiple Sclerosis
Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.
Multiple System Atrophy
Epigenetic modulation of AREL1 and increased HLA expression in brains of multiple system atrophy patients.
Mumps
Angiomotin-Like 1 Links Paramyxovirus M Proteins to NEDD4 Family Ubiquitin Ligases.
Muscular Atrophy
Long noncoding RNA SMUL suppresses SMURF2 production-mediated muscle atrophy via nonsense-mediated mRNA decay.
Muscular Atrophy
Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice.
Muscular Atrophy
PDLIM7 is a novel target of the ubiquitin ligase Nedd4-1 in skeletal muscle.
Muscular Atrophy
The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice.
Muscular Diseases
VCP/p97 increases BMP signaling by accelerating ubiquitin ligase Smurf1 degradation.
Myocardial Infarction
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Myocardial Ischemia
Characterization of novel lncRNAs in upper thoracic spinal cords of rats with myocardial ischemia-reperfusion injuries.
Myocardial Ischemia
Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs.
Myotonic Dystrophy
Abnormal splicing of NEDD4 in myotonic dystrophy type 2: possible link to statin adverse reactions.
Nasal Polyps
UBE3C genetic variations as potent markers of nasal polyps in Korean asthma patients.
Nasopharyngeal Carcinoma
Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population.
Nasopharyngeal Carcinoma
NEDD4 is involved in acquisition of epithelial-mesenchymal transition in cisplatin-resistant nasopharyngeal carcinoma cells.
Nasopharyngeal Carcinoma
Paeoniflorin exhibits antitumor effects in nasopharyngeal carcinoma cells through downregulation of NEDD4.
Neoplasm Metastasis
A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis.
Neoplasm Metastasis
An outlined review for the role of Nedd4-1 and Nedd4-2 in lung disorders.
Neoplasm Metastasis
Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2.
Neoplasm Metastasis
Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity.
Neoplasm Metastasis
Decreased expression of NEDD4L contributes to NSCLC progression and metastasis.
Neoplasm Metastasis
Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient.
Neoplasm Metastasis
Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas.
Neoplasm Metastasis
High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma.
Neoplasm Metastasis
miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic cancer.
Neoplasm Metastasis
MiR-542-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting UBE3C.
Neoplasm Metastasis
miR-93 promotes TGF-?-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells.
Neoplasm Metastasis
NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma.
Neoplasm Metastasis
NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation.
Neoplasm Metastasis
Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis.
Neoplasm Metastasis
Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue.
Neoplasm Metastasis
Oncogenic UBE3C promotes breast cancer progression by activating Wnt/?-catenin signaling.
Neoplasm Metastasis
PRRG4 promotes breast cancer metastasis through the recruitment of NEDD4 and downregulation of Robo1.
Neoplasm Metastasis
RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis.
Neoplasm Metastasis
SMAD specific E3 ubiquitin protein ligase 1 promotes ovarian cancer cell migration and invasion via the activation of the RhoA/ROCK signaling pathway.
Neoplasm Metastasis
Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promotes Thyroid Cancer Cell Proliferation and Migration via Ubiquitin-Dependent Degradation of Kisspeptin-1.
Neoplasm Metastasis
Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness.
Neoplasm Metastasis
SMURF1 promotes the proliferation, migration and invasion of gastric cancer cells.
Neoplasm Metastasis
Smurf1 regulation of DAB2IP controls cell proliferation and migration.
Neoplasm Metastasis
SMURF1, a promoter of tumor cell progression?
Neoplasm Metastasis
Smurf1-positive expression indicates favorable survival for resected non-small cell lung cancer patients.
Neoplasm Metastasis
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.
Neoplasm Metastasis
SND1 acts downstream of TGF?1 and upstream of Smurf1 to promote breast cancer metastasis.
Neoplasm Metastasis
Structure of the HECT domain of human WWP2.
Neoplasm Metastasis
The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer.
Neoplasm Metastasis
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
Neoplasm Metastasis
The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways.
Neoplasm Metastasis
The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2.
Neoplasm Metastasis
UBE3C Promotes Growth and Metastasis of Renal Cell Carcinoma via Activating Wnt/?-Catenin Pathway.
Neoplasm Metastasis
Ubiquitin ligase SMURF1 functions as a prognostic marker and promotes growth and metastasis of clear cell renal cell carcinoma.
Neoplasm Metastasis
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.
Neoplasm Metastasis
Ubiquitination by HUWE1 in tumorigenesis and beyond.
Neoplasm Metastasis
Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma.
Neoplasm Metastasis
WW domain-mediated regulation and activation of E3 ubiquitin ligase Suppressor of Deltex.
Neoplasms
A conformational switch regulates the ubiquitin ligase HUWE1.
Neoplasms
A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1.
Neoplasms
A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis.
Neoplasms
A Potential Role for HUWE1 in Modulating Cisplatin Sensitivity.
Neoplasms
A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.
Neoplasms
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20.
Neoplasms
A Variant Smurf2 Protects Mice Against Colitis-Associated Colon Cancer by Inducing Transforming Growth Factor ? Signaling.
Neoplasms
Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch.
Neoplasms
Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer.
Neoplasms
An endogenous retrovirus mediating deletion of alpha beta T cells?
Neoplasms
Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway.
Neoplasms
Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif.
Neoplasms
ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.
Neoplasms
ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance.
Neoplasms
Bortezomib attenuates renal interstitial fibrosis in kidney transplantation via regulating the EMT induced by TNF-?-Smurf1-Akt-mTOR-P70S6K pathway.
Neoplasms
Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis.
Neoplasms
Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner.
Neoplasms
Circulating essential metals and lung cancer: Risk assessment and potential molecular effects.
Neoplasms
CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.
Neoplasms
Clinical significance of the ubiquitin ligase E3C in hepatocellular carcinoma revealed by exome sequencing.
Neoplasms
Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer.
Neoplasms
CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1-/- cells.
Neoplasms
Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases.
Neoplasms
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells.
Neoplasms
Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner.
Neoplasms
CRL4BRBBP7 targets HUWE1 for ubiquitination and proteasomal degradation.
Neoplasms
Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity.
Neoplasms
Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway.
Neoplasms
Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells.
Neoplasms
Decreased expression of NEDD4L contributes to NSCLC progression and metastasis.
Neoplasms
Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient.
Neoplasms
Degradation of hDlg and MAGIs by human papillomavirus E6 is E6-AP-independent.
Neoplasms
Deletion of SMURF 1 represses ovarian cancer invasion and EMT by modulating the DAB2IP/AKT/Skp2 feedback loop.
Neoplasms
Derangements in HUWE1/c-MYC pathway confer sensitivity to the BET bromodomain inhibitor GS-626510 in uterine cervical carcinoma.
Neoplasms
Detection of E6-AP as a potential therapeutic target in cervical specimen of HPV-infected women.
Neoplasms
Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1.
Neoplasms
Divergent viral superantigens delete V beta 5+ T lymphocytes.
Neoplasms
DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation.
Neoplasms
Down-regulation of HECTD3 by HER2 inhibition makes serous ovarian cancer cells sensitive to platinum treatment.
Neoplasms
Downregulation of Nedd4L predicts poor prognosis, promotes tumor growth and inhibits MAPK/ERK signal pathway in hepatocellular carcinoma.
Neoplasms
Downregulation of Smurf2 ubiquitin ligase in pancreatic cancer cells reversed TGF-?-induced tumor formation.
Neoplasms
Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.
Neoplasms
E3 ubiquitin ligase SMURF2 prevents colorectal cancer by reducing the stability of the YY1 protein and inhibiting the SENP1/c-myc axis.
Neoplasms
E3 ubiquitin ligase Smurf2: a prognostic factor in microsatellite stable colorectal cancer.
Neoplasms
E3 Ubiquitin Ligase TRIP12: Regulation, Structure, and Physiopathological Functions.
Neoplasms
E6-associated protein (E6-AP) is a dual function coactivator of steroid hormone receptors.
Neoplasms
Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma.
Neoplasms
Ehrlichia chaffeensis TRP120-mediated ubiquitination and proteasomal degradation of tumor suppressor FBW7 increases oncoprotein stability and promotes infection.
Neoplasms
Emerging views of mitophagy in immunity and autoimmune diseases.
Neoplasms
Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci.
Neoplasms
Estradiol promotes rapid degradation of HER3 in ER-positive breast cancer cell line MCF-7.
Neoplasms
Exosomal hsa-miR199a-3p Promotes Proliferation and Migration in Neuroblastoma.
Neoplasms
Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas.
Neoplasms
Generation of SMURF2 knockout human cells using the CRISPR/Cas9 system.
Neoplasms
Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53.
Neoplasms
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Neoplasms
HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation.
Neoplasms
HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.
Neoplasms
HERC4 exerts an anti-tumor role through destabilizing the oncoprotein Smo.
Neoplasms
HERC4 Is Overexpressed in Hepatocellular Carcinoma and Contributes to the Proliferation and Migration of Hepatocellular Carcinoma Cells.
Neoplasms
High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma.
Neoplasms
Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes.
Neoplasms
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53.
Neoplasms
HUWE1 cooperates with RAS activation to control leukemia cell proliferation and human hematopoietic stem cells differentiation fate.
Neoplasms
HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.
Neoplasms
HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans.
Neoplasms
Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3-H19 Cascade.
Neoplasms
HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.
Neoplasms
HUWE1 upregulation has tumor suppressive effect in human prostate cancer cell lines through c-Myc.
Neoplasms
Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.
Neoplasms
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
Neoplasms
Impact of E6-associated protein on the proliferation and invasion of prostate cancer cells in bone metastasis.
Neoplasms
Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis.
Neoplasms
Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells.
Neoplasms
Integrated bioinformatics analysis of the NEDD4 family reveals a prognostic value of NEDD4L in clear-cell renal cell cancer.
Neoplasms
Integrated molecular analysis to investigate the role of microRNAs in pancreatic tumour growth and progression.
Neoplasms
Interaction of the E6 protein of human papillomavirus with cellular proteins.
Neoplasms
Intestinal knockout of Nedd4 enhances growth of Apc(min) tumors.
Neoplasms
IRAK2 counterbalances oncogenic Smurf1 in colon cancer cells by dictating ER stress.
Neoplasms
Itch: a HECT-type E3 ligase regulating immunity, skin and cancer.
Neoplasms
Knockdown of long noncoding RNA XIST mitigates the apoptosis and inflammatory injury of microglia cells after spinal cord injury through miR-27a/Smurf1 axis.
Neoplasms
KRAS Protein Stability Is Regulated through SMURF2: UBCH5 Complex-Mediated ?-TrCP1 Degradation.
Neoplasms
LIMCH1 suppress the growth of lung cancer by interacting with HUWE1 to sustain p53 stability.
Neoplasms
Low Expression of Smurf1 Enhances the Chemosensitivity of Human Colorectal Cancer to Gemcitabine and Cisplatin in Patient-Derived Xenograft Models.
Neoplasms
LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.
Neoplasms
Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer.
Neoplasms
MicroRNA-125a inhibits tumorigenesis by targeting Smurf1 in colorectal carcinoma.
Neoplasms
MicroRNA-27 Inhibits Autophagy and Promotes Proliferation of Multiple Myeloma Cells by Targeting the NEDD4/Notch1 Axis.
Neoplasms
MicroRNA-424 regulates cisplatin resistance of gastric cancer by targeting SMURF1 based on GEO database and primary validation in human gastric cancer tissues.
Neoplasms
MicroRNA-497 inhibition of ovarian cancer cell migration and invasion through targeting of SMAD specific E3 ubiquitin protein ligase 1.
Neoplasms
MiR-153 promotes breast cancer cell apoptosis by targeting HECTD3.
Neoplasms
MiR-195 and miR-497 suppress tumorigenesis in lung cancer by inhibiting SMURF2-induced TGF-? receptor I ubiquitination.
Neoplasms
MiR-542-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting UBE3C.
Neoplasms
Molecular functions of NEDD4 E3 ubiquitin ligases in cancer.
Neoplasms
Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells.
Neoplasms
Multiple regions of E6AP (UBE3A) contribute to interaction with papillomavirus E6 proteins and the activation of ubiquitin ligase activity.
Neoplasms
NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.
Neoplasms
NEDD4 Depletion Inhibits Hepatocellular Carcinoma Growth via Targeting PTEN.
Neoplasms
NEDD4 E3 ligase: Functions and mechanism in human cancer.
Neoplasms
NEDD4 Family of E3 Ubiquitin Ligases in Breast Cancer: Spotlight on SMURFs, WWPs and NEDD4.
Neoplasms
NEDD4 Induces K48-Linked Degradative Ubiquitination of Hepatitis B Virus X Protein and Inhibits HBV-Associated HCC Progression.
Neoplasms
NEDD4 is involved in acquisition of epithelial-mesenchymal transition in cisplatin-resistant nasopharyngeal carcinoma cells.
Neoplasms
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.
Neoplasms
NEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma.
Neoplasms
NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma.
Neoplasms
NEDD4 promotes cell growth and motility in hepatocellular carcinoma.
Neoplasms
NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.
Neoplasms
NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation.
Neoplasms
NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling.
Neoplasms
Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma.
Neoplasms
NEDD4-1 and PTEN expression in keloid scarring.
Neoplasms
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.
Neoplasms
NEDD4: a promising target for cancer therapy.
Neoplasms
NEDD4: The founding member of a family of ubiquitin-protein ligases.
Neoplasms
NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter.
Neoplasms
Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue.
Neoplasms
NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling.
Neoplasms
Neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) regulates hydrogen peroxide-induced cell proliferation and death through inhibition of Hippo signaling.
Neoplasms
Nitidine chloride suppresses NEDD4 expression in lung cancer cells.
Neoplasms
NMR uncovers direct interaction between human NEDD4-1 and p34(SEI-1).
Neoplasms
Oncogenic function of p34SEI-1 via NEDD4?1?mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway.
Neoplasms
Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas.
Neoplasms
Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation.
Neoplasms
Oncogenic UBE3C promotes breast cancer progression by activating Wnt/?-catenin signaling.
Neoplasms
Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary tumorigenesis.
Neoplasms
Pan-cancer Analysis of NEDD4L and Its Tumor Suppressor Effects in Clear Cell Renal Cell Carcinoma.
Neoplasms
Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
Neoplasms
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Neoplasms
Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response.
Neoplasms
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.
Neoplasms
Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas.
Neoplasms
PTEN is a protein tyrosine phosphatase for IRS1.
Neoplasms
Quantitative Lys-?-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.
Neoplasms
R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc.
Neoplasms
RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis.
Neoplasms
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation.
Neoplasms
Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.
Neoplasms
Regulation of Krüppel-like factor 8 by the NEDD4 E3 ubiquitin ligase.
Neoplasms
Regulation of turnover of tumor suppressor p53 and cell growth by E6-AP, a ubiquitin protein ligase mutated in Angelman mental retardation syndrome.
Neoplasms
Reversible regulation of SATB1 ubiquitination by USP47 and SMURF2 mediates colon cancer cell proliferation and tumor progression.
Neoplasms
Role of altered expression of Nedd4L in the pathogenesis of systemic malignancies.
Neoplasms
SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization.
Neoplasms
SCF?-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway.
Neoplasms
Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors.
Neoplasms
SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease.
Neoplasms
SMAD specific E3 ubiquitin protein ligase 1 promotes ovarian cancer cell migration and invasion via the activation of the RhoA/ROCK signaling pathway.
Neoplasms
Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promotes Thyroid Cancer Cell Proliferation and Migration via Ubiquitin-Dependent Degradation of Kisspeptin-1.
Neoplasms
SMURF1 amplification promotes invasiveness in pancreatic cancer.
Neoplasms
SMURF1 promotes the proliferation, migration and invasion of gastric cancer cells.
Neoplasms
Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility.
Neoplasms
SMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma.
Neoplasms
SMURF1, a promoter of tumor cell progression?
Neoplasms
Smurf1-positive expression indicates favorable survival for resected non-small cell lung cancer patients.
Neoplasms
Smurf1: a link between cell polarity and ubiquitination.
Neoplasms
Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner.
Neoplasms
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.
Neoplasms
SMURF2 prevents detrimental changes to chromatin, protecting human dermal fibroblasts from chromosomal instability and tumorigenesis.
Neoplasms
Smurf2 regulates stability and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin.
Neoplasms
Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.
Neoplasms
Smurf2-Mediated Stabilization of DNA Topoisomerase II? Controls Genomic Integrity.
Neoplasms
SMURF2-mediated ubiquitin signaling plays an essential role in the regulation of PARP1 PARylating activity, molecular interactions, and functions in mammalian cells.
Neoplasms
Somatic mutations in early onset luminal breast cancer.
Neoplasms
Specific recognition of four-way DNA junctions by the C-terminal zinc-binding domain of HPV oncoprotein E6.
Neoplasms
Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activities in vitro.
Neoplasms
Suppression of human tumor cell proliferation by Smurf2-induced senescence.
Neoplasms
Suppression of the Smurf1 Expression Inhibits Tumor Progression in Gliomas.
Neoplasms
Systems biology approach to identification of biomarkers for metastatic progression in gastric cancer.
Neoplasms
Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints.
Neoplasms
Targeting of the E3 ubiquitin-protein ligase HUWE1 impairs DNA repair capacity and tumor growth in preclinical multiple myeloma models.
Neoplasms
The Anti-proliferative Response of Indole-3-carbinol in human melanoma cells is Triggered by an Interaction with NEDD4-1 and Disruption of Wild-type PTEN Degradation.
Neoplasms
The anticancer effects of curcumin via targeting the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway.
Neoplasms
The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/?-catenin pathway by inhibiting the proteasome.
Neoplasms
The correlation between NEDD4L and HIF-1? levels as a gastric cancer prognostic marker.
Neoplasms
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
Neoplasms
The dual function steroid receptor coactivator/ubiquitin protein-ligase integrator E6-AP is overexpressed in mouse mammary tumorigenesis.
Neoplasms
The E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation.
Neoplasms
The E3 ligase HUWE1 mediates TGFBR2 ubiquitination and promotes gastric cancer cell proliferation, migration, and invasion.
Neoplasms
The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer.
Neoplasms
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
Neoplasms
The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling.
Neoplasms
The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer.
Neoplasms
The Effects of WW2/WW3 Domains of Smurf2 Molecule on CD4+CD25+/CD4+ Proportion in Spleen of 4T1 Tumor Bearing BALB/c Mice.
Neoplasms
The Emerging Roles of the HERC Ubiquitin Ligases in Cancer.
Neoplasms
The Epstein-Barr virus protein, latent membrane protein 2A, co-opts tyrosine kinases used by the T cell receptor.
Neoplasms
The expression and clinical significance of HERC4 in breast cancer.
Neoplasms
The HECT E3 Ligase E6AP/UBE3A as a Therapeutic Target in Cancer and Neurological Disorders.
Neoplasms
The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8.
Neoplasms
The HECTD3 E3 ubiquitin ligase suppresses cisplatin-induced apoptosis via stabilizing MALT1.
Neoplasms
The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways.
Neoplasms
The Long Non-Coding RNA MIR503HG Enhances Proliferation of Human ALK-Negative Anaplastic Large-Cell Lymphoma.
Neoplasms
The many substrates and functions of NEDD4-1.
Neoplasms
The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase.
Neoplasms
The NEDD4-1 E3 ubiquitin ligase: A potential molecular target for bortezomib sensitivity in multiple myeloma.
Neoplasms
The Nedd4-like family of E3 ubiquitin ligases and cancer.
Neoplasms
The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2.
Neoplasms
The oncogenic role of human papillomavirus proteins.
Neoplasms
The role of E3 ubiquitin ligase HECTD3 in cancer and beyond.
Neoplasms
The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma.
Neoplasms
The roles of E6-AP and MDM2 in p53 regulation in human papillomavirus-positive cervical cancer cells.
Neoplasms
The structure and regulation of the E3 ubiquitin ligase HUWE1 and its biological functions in cancer.
Neoplasms
The study on copy number alteration of clear cell renal cancer in Chinese population.
Neoplasms
The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.
Neoplasms
The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.
Neoplasms
Tobramycin suppresses HUWE1 degradation to control MCL-1 stability during tumour development.
Neoplasms
Transcription alterations of members of the ubiquitin-proteasome network in prostate carcinoma.
Neoplasms
TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects.
Neoplasms
Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation.
Neoplasms
Tudor tells about new twists in the story tale of SMURFs.
Neoplasms
Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.
Neoplasms
Tumor Necrosis Factor Promotes Runx2 Degradation through Up-regulation of Smurf1 and Smurf2 in Osteoblasts.
Neoplasms
Tumor necrosis factor-? enhances the transcription of Smad ubiquitination regulatory factor 1 in an activating protein-1- and Runx2-dependent manner.
Neoplasms
Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation.
Neoplasms
Tumour suppressive function of HUWE1 in thyroid cancer.
Neoplasms
UBE3C Promotes Growth and Metastasis of Renal Cell Carcinoma via Activating Wnt/?-Catenin Pathway.
Neoplasms
UBE3C promotes proliferation and inhibits apoptosis by activating the ?-catenin signaling via degradation of AXIN1 in gastric cancer.
Neoplasms
Ubiquitin ligase SMURF1 functions as a prognostic marker and promotes growth and metastasis of clear cell renal cell carcinoma.
Neoplasms
Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.
Neoplasms
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.
Neoplasms
Ubiquitin-protein ligase E3C promotes glioma progression by mediating the ubiquitination and degrading of Annexin A7.
Neoplasms
Ubiquitination and the ubiquitin - proteasome system in the pathogenesis and treatment of squamous head and neck carcinoma.
Neoplasms
Ubiquitination by HUWE1 in tumorigenesis and beyond.
Neoplasms
Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy.
Neoplasms
Ubiquitination of tumor necrosis factor receptor-associated factor 4 (TRAF4) by Smad ubiquitination regulatory factor 1 (Smurf1) regulates motility of breast epithelial and cancer cells.
Neoplasms
Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
Neoplasms
Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma.
Neoplasms
Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone.
Neoplasms
WW domain-mediated regulation and activation of E3 ubiquitin ligase Suppressor of Deltex.
Neoplasms
X-Linked Huwe1 Is Essential for Oocyte Maturation and Preimplantation Embryo Development.
Nervous System Diseases
Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2.
Nervous System Diseases
The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily.
Nervous System Diseases
The HECT E3 Ligase E6AP/UBE3A as a Therapeutic Target in Cancer and Neurological Disorders.
Nervous System Diseases
Ubiquitin ligase E6-AP and its role in human disease.
Neuroblastoma
A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner.
Neuroblastoma
E3 Ubiquitin Ligase Nedd4 Promotes Japanese Encephalitis Virus Replication by Suppressing Autophagy in Human Neuroblastoma Cells.
Neuroblastoma
Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.
Neuroblastoma
Nedd4 Binding Protein 1 (N4BP1) and TNFAIP3 Interacting Protein 1 (TNIP1) control MHC-1 display in neuroblastoma.
Neuroblastoma
The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway.
Neuroblastoma
The histone deacetylase SIRT2 stabilizes Myc oncoproteins.
Neuroblastoma
Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth.
Neurodegenerative Diseases
Administration of CoQ10 analogue ameliorates dysfunction of the mitochondrial respiratory chain in a mouse model of Angelman syndrome.
Neurodegenerative Diseases
Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy.
Neurodegenerative Diseases
Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke.
Neurodegenerative Diseases
The Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins.
Neurodegenerative Diseases
Upregulation of the E3 ligase NEDD4-1 by Oxidative Stress Degrades IGF-1 Receptor Protein in Neurodegeneration.
Neuroinflammatory Diseases
Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.
Neuroinflammatory Diseases
The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice.
Neuroinflammatory Diseases
The Role of Smurf1 in Neuronal Necroptosis after Lipopolysaccharide-Induced Neuroinflammation.
Nevus
Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
Non-alcoholic Fatty Liver Disease
Non-proteolytic ubiquitin modification of PPAR? by Smurf1 protects the liver from steatosis.
Non-alcoholic Fatty Liver Disease
Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner.
Non-alcoholic Fatty Liver Disease
The ménage à trois of autophagy, lipid droplets and liver disease.
Obesity
A functional variant of NEDD4L is associated with obesity and related phenotypes in a Han population of Southern China.
Obesity
An investigation of obesity susceptibility genes in Northern Han Chinese by targeted resequencing.
Obesity
Nedd4 Haploinsufficient Mice Display Moderate Insulin Resistance, Enhanced Lipolysis, and Protection against High-fat Diet Induced Obesity.
Obesity
The impacts of the interaction of genetic variation, CYP11?2 and NEDD4L, with sodium intake on pediatric obesity with gender difference: a 3-year panel study.
Obesity
[Association of the rs4149601 polymorphism of NEDD4L gene with obesity in Xinjiang Kazakh population].
Osteitis Deformans
VCP/p97 increases BMP signaling by accelerating ubiquitin ligase Smurf1 degradation.
Osteoarthritis
Long noncoding RNA LINC00671 exacerbates osteoarthritis by promoting ONECUT2-mediated Smurf2 expression and extracellular matrix degradation.
Osteoarthritis
Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin.
Osteoarthritis
SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis.
Osteoarthritis
Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.
Osteonecrosis
microRNA-148a-3p in extracellular vesicles derived from bone marrow mesenchymal stem cells suppresses SMURF1 to prevent osteonecrosis of femoral head.
Osteoporosis
Fragile Bones Secondary to SMURF1 Gene Duplication.
Osteoporosis
Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis.
Osteoporosis
Overexpression of miR-195-5p reduces osteoporosis through activating BMP-2/SMAD/Akt/RUNX2 pathway via targeting SMURF1.
Osteoporosis
Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.
Osteoporosis
Silencing long noncoding RNA colon cancer-associated transcript-1 upregulates microRNA-34a-5p to promote proliferation and differentiation of osteoblasts in osteoporosis.
Osteoporosis
SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts.
Osteosarcoma
DNA methylation-mediated downregulation of PTPN3 attenuates to boost TGF-? signaling in osteosarcoma cells.
Osteosarcoma
MiR-542-5p is a negative prognostic factor and promotes osteosarcoma tumorigenesis by targeting HUWE1.
Osteosarcoma
Phospho-Smad1 modulation by Nedd4 E3 ligase in BMP/TGF? signaling.
Osteosarcoma
RLIM interacts with Smurf2 and promotes TGF-? induced U2OS cell migration.
Osteosarcoma
Screening and Interaction Analysis of Key Genes in miR-542-3p Over- Expressed Osteosarcoma Cells by Bioinformatics.
Ovarian Neoplasms
DDB2 modulates TGF-? signal transduction in human ovarian cancer cells by downregulating NEDD4L.
Ovarian Neoplasms
Deletion of SMURF 1 represses ovarian cancer invasion and EMT by modulating the DAB2IP/AKT/Skp2 feedback loop.
Ovarian Neoplasms
Down-regulation of HECTD3 by HER2 inhibition makes serous ovarian cancer cells sensitive to platinum treatment.
Ovarian Neoplasms
Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3-H19 Cascade.
Ovarian Neoplasms
MicroRNA-497 inhibition of ovarian cancer cell migration and invasion through targeting of SMAD specific E3 ubiquitin protein ligase 1.
Ovarian Neoplasms
Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue.
Ovarian Neoplasms
The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency.
Pancreatic Neoplasms
Downregulation of Smurf2 ubiquitin ligase in pancreatic cancer cells reversed TGF-?-induced tumor formation.
Pancreatic Neoplasms
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
Pancreatic Neoplasms
miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic cancer.
Pancreatic Neoplasms
NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter.
Pancreatic Neoplasms
SMURF1 amplification promotes invasiveness in pancreatic cancer.
Pancreatic Neoplasms
The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer.
Pancreatic Neoplasms
The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer.
Pancreatic Neoplasms
The histone deacetylase SIRT2 stabilizes Myc oncoproteins.
Pancreatic Neoplasms
The Nedd4-like family of E3 ubiquitin ligases and cancer.
Papilloma
Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.
Papilloma
Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases.
Paramyxoviridae Infections
Emerging views of mitophagy in immunity and autoimmune diseases.
Parkinson Disease
E3 Ubiquitin Ligases in Neurological Diseases: Focus on Gigaxonin and Autophagy.
Parkinson Disease
Enhanced ubiquitin-dependent degradation by Nedd4 protects against ?-synuclein accumulation and toxicity in animal models of Parkinson's disease.
Parkinson Disease
Loss of NEDD4 contributes to RTP801 elevation and neuron toxicity: implications for Parkinson's disease.
Parkinson Disease
Reynosin protects against neuronal toxicity in dopamine-induced SH-SY5Y cells and 6-hydroxydopamine-lesioned rats as models of Parkinson's disease: Reciprocal up-regulation of E6-AP and down-regulation of ?-synuclein.
Parkinson Disease
Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway.
Parkinsonian Disorders
Emerging views of mitophagy in immunity and autoimmune diseases.
Parkinsonian Disorders
Human disorders of ubiquitination and proteasomal degradation.
Pediatric Obesity
The impacts of the interaction of genetic variation, CYP11?2 and NEDD4L, with sodium intake on pediatric obesity with gender difference: a 3-year panel study.
Peripheral Nervous System Diseases
Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli.
Periventricular Nodular Heterotopia
A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.
Periventricular Nodular Heterotopia
Admixed phenotype of NEDD4L associated periventricular nodular heterotopia: A case report.
Periventricular Nodular Heterotopia
Author Correction: A missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria, and cleft palate.
Periventricular Nodular Heterotopia
Familial NEDD4L variant in periventricular nodular heterotopia and in a fetus with hypokinesia and flexion contractures.
Periventricular Nodular Heterotopia
Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.
Periventricular Nodular Heterotopia
Recurrent NEDD4L Variant in Periventricular Nodular Heterotopia, Polymicrogyria and Syndactyly.
Periventricular Nodular Heterotopia
[Clinical and genetic analysis of a patient with periventricular nodular heterotopia 7 caused by NEDD4L gene variant].
Pituitary Neoplasms
Correlation of NEDD4-1 and PTEN expression with the invasive capacity of pituitary adenomas.
Pneumonia
Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice.
Polycythemia
Human disorders of ubiquitination and proteasomal degradation.
Polyendocrinopathies, Autoimmune
Human disorders of ubiquitination and proteasomal degradation.
Polymicrogyria
A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.
Polymicrogyria
Author Correction: A missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria, and cleft palate.
Polymicrogyria
Recurrent NEDD4L Variant in Periventricular Nodular Heterotopia, Polymicrogyria and Syndactyly.
Pre-Eclampsia
Novel SNPs of WNK1 and AKR1C3 are associated with preeclampsia.
Progeria
Smurf2 regulates stability and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin.
Prostatic Hyperplasia
Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia.
Prostatic Neoplasms
A Feedback Loop between the Androgen Receptor and a NEDD4-binding Protein, PMEPA1, in Prostate Cancer Cells.
Prostatic Neoplasms
Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells.
Prostatic Neoplasms
Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2.
Prostatic Neoplasms
Diosgenin inhibits the expression of NEDD4 in prostate cancer cells.
Prostatic Neoplasms
E3 ubiquitin protein ligase, E6-associated protein (E6-AP) regulates PI3K-Akt signaling and prostate cell growth.
Prostatic Neoplasms
HUWE1 upregulation has tumor suppressive effect in human prostate cancer cell lines through c-Myc.
Prostatic Neoplasms
IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way.
Prostatic Neoplasms
Impact of E6-associated protein on the proliferation and invasion of prostate cancer cells in bone metastasis.
Prostatic Neoplasms
LncRNA SNHG3 sponges miR-577 to up-regulate SMURF1 expression in prostate cancer.
Prostatic Neoplasms
Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer.
Prostatic Neoplasms
Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.
Prostatic Neoplasms
Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia.
Prostatic Neoplasms
R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc.
Prostatic Neoplasms
Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN.
Prostatic Neoplasms
The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling.
Pseudohypoaldosteronism
Molecular pathogenesis of renal pseudohypoaldosteronism type 1.
Pseudohypoaldosteronism
Pseudohypoaldosteronism type 1 and the genes encoding prostasin, alpha-spectrin, and Nedd4.
Psoriasis
E3 ubiquitin ligase NEDD4L negatively regulates keratinocyte hyperplasia by promoting GP130 degradation.
Pulmonary Arterial Hypertension
MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.
Pulmonary Arterial Hypertension
MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1.
Pulmonary Arterial Hypertension
Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
Atrophy and hypertrophy signaling in the diaphragm of patients with COPD.
Pulmonary Disease, Chronic Obstructive
Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks.
Pulmonary Disease, Chronic Obstructive
Cellular Markers of Muscle Atrophy in Chronic Obstructive Pulmonary Disease (COPD).
Pulmonary Edema
MicroRNA 16 modulates epithelial sodium channel in human alveolar epithelial cells.
Pulmonary Fibrosis
NADPH oxidase DUOX1 sustains TGF-?1 signalling and promotes lung fibrosis.
Pulmonary Fibrosis
The effects of miR-27a-3p-mediated Smurf2 on bleomycin A5-induced pulmonary fibrosis in rats.
Rabies
ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response.
Renal Insufficiency, Chronic
A variant in the NEDD4L gene associates with hypertension in chronic kidney disease in the southeastern Han Chinese population.
Renal Insufficiency, Chronic
cMet agonistic antibody prevents acute kidney injury to chronic kidney disease transition by suppressing Smurf1 and activating Smad7.
Reperfusion Injury
Associations between Huwe1 and autophagy in rat cerebral neuron oxygen?glucose deprivation and reperfusion injury.
Reperfusion Injury
Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells.
Reperfusion Injury
Inhibition of Smurf2 translation by miR-322/503 protects from ischemia reperfusion injury by modulating EZH2/Akt/GSK3? signaling.
Reperfusion Injury
Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion.
RNA Virus Infections
Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome.
Sarcoma
miR-4319 inhibited the development of thyroid cancer by modulating FUS-stabilized SMURF1.
Sarcoma
Suppression of human tumor cell proliferation by Smurf2-induced senescence.
Sarcoma, Avian
An LYPSL late domain in the Gag protein contributes to the efficient release and replication of Rous sarcoma virus.
Sarcoma, Avian
Avian sarcoma virus and human immunodeficiency virus, type 1 use different subsets of ESCRT proteins to facilitate the budding process.
Sarcoma, Avian
Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells.
Sarcoma, Avian
Role of Nedd4 and ubiquitination of Rous sarcoma virus Gag in budding of virus-like particles from cells.
Sarcoma, Avian
The functionally exchangeable L domains in RSV and HIV-1 Gag direct particle release through pathways linked by Tsg101.
Sarcoma, Avian
Tsg101 can replace Nedd4 function in ASV Gag release but not membrane targeting.
Seizures
A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.
Seizures
The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily.
Sepsis
E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation.
Silicosis
MiR-411-3p alleviates Silica-induced pulmonary fibrosis by regulating Smurf2/TGF-? signaling.
Skin Diseases
NEDD4 Is Involved in Inflammation Development during Keloid Formation.
Spasms, Infantile
A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.
Spinal Cord Injuries
microRNA-125b and its downstream Smurf1/KLF2/ATF2 axis as important promoters on neurological function recovery in rats with spinal cord injury.
Spinal Cord Injuries
Up-regulation of Smurf1 after spinal cord injury in adult rats.
Spinocerebellar Ataxias
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.
Spinocerebellar Ataxias
Pentanucleotide repeat-primed PCR for genetic diagnosis of spinocerebellar ataxia type 31.
Squamous Cell Carcinoma of Head and Neck
SMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects.
Starvation
Hepatic PPAR? function is controlled by polyubiquitination and proteasome-mediated degradation via the coordinated actions of PAQR3 and HUWE1.
Starvation
Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.
Starvation
The HECT E3 ubiquitin ligase NEDD4 interacts with and ubiquitylates SQSTM1 for inclusion body autophagy.
Starvation
The ubiquitin-protein ligase Nedd4 targets Notch1 in skeletal muscle and distinguishes the subset of atrophies caused by reduced muscle tension.
Starvation
ULK1 ubiquitylation is regulated by phosphorylation on its carboxy terminus.
Stomach Neoplasms
Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient.
Stomach Neoplasms
Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas.
Stomach Neoplasms
LINC00355 induces gastric cancer proliferation and invasion through promoting ubiquitination of P53.
Stomach Neoplasms
MicroRNA-424 regulates cisplatin resistance of gastric cancer by targeting SMURF1 based on GEO database and primary validation in human gastric cancer tissues.
Stomach Neoplasms
miR-1254 inhibits cell proliferation, migration, and invasion by down-regulating Smurf1 in gastric cancer.
Stomach Neoplasms
SMURF1 promotes the proliferation, migration and invasion of gastric cancer cells.
Stomach Neoplasms
The correlation between NEDD4L and HIF-1? levels as a gastric cancer prognostic marker.
Stomach Neoplasms
The E3 ligase HUWE1 mediates TGFBR2 ubiquitination and promotes gastric cancer cell proliferation, migration, and invasion.
Stomach Neoplasms
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
Stomach Neoplasms
UBE3C promotes proliferation and inhibits apoptosis by activating the ?-catenin signaling via degradation of AXIN1 in gastric cancer.
Stroke
Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity.
Stroke
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.
Stroke
Identification of Co-expressed Genes Between Atrial Fibrillation and Stroke.
Syndactyly
A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.
Syndactyly
Familial NEDD4L variant in periventricular nodular heterotopia and in a fetus with hypokinesia and flexion contractures.
Syndactyly
Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.
Syndactyly
Recurrent NEDD4L Variant in Periventricular Nodular Heterotopia, Polymicrogyria and Syndactyly.
Thyroid Neoplasms
miR-4319 inhibited the development of thyroid cancer by modulating FUS-stabilized SMURF1.
Thyroid Neoplasms
REG? potentiates TGF-?/Smad signal dependent epithelial-mesenchymal transition in thyroid cancer cells.
Thyroid Neoplasms
Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promotes Thyroid Cancer Cell Proliferation and Migration via Ubiquitin-Dependent Degradation of Kisspeptin-1.
Thyroid Neoplasms
Tumour suppressive function of HUWE1 in thyroid cancer.
Trauma, Nervous System
Up-regulation of Smurf1 after spinal cord injury in adult rats.
Triple Negative Breast Neoplasms
Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.
Triple Negative Breast Neoplasms
MiR-153 promotes breast cancer cell apoptosis by targeting HECTD3.
Triple Negative Breast Neoplasms
The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L.
Triple Negative Breast Neoplasms
Transcriptome-wide analysis and modelling of prognostic alternative splicing signatures in invasive breast cancer: a prospective clinical study.
Tuberculosis
The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.
Tuberculosis
The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.
Tuberculosis, Meningeal
The impact of common Smurf1 gene variants on the risk, clinical characteristics and short-term prognosis of tuberculous meningitis.
Tuberculosis, Pulmonary
The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.
Ureteral Obstruction
Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis.
Ureteral Obstruction
HUWE1 promotes EGFR ubiquitination and degradation to protect against renal tubulointerstitial fibrosis.
Urinary Bladder Neoplasms
Inhibition of NEDD4 inhibits cell growth and invasion and induces cell apoptosis in bladder cancer cells.
Urinary Bladder Neoplasms
The Nedd4-like family of E3 ubiquitin ligases and cancer.
Uterine Cervical Neoplasms
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells.
Uterine Cervical Neoplasms
Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53.
Uterine Cervical Neoplasms
The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase.
Uterine Cervical Neoplasms
The roles of E6-AP and MDM2 in p53 regulation in human papillomavirus-positive cervical cancer cells.
Uterine Cervical Neoplasms
Tristetraprolin and E6-AP: Killing the messenger in cervical cancer.
Uterine Cervical Neoplasms
[RNA interference of HERC4 inhibits proliferation, apoptosis and migration of cervical cancer Hela cells].
Vascular Calcification
Nedd4 Deficiency in Vascular Smooth Muscle Promotes Vascular Calcification by Stabilizing pSmad1.
Vesicular Stomatitis
Budding of PPxY-containing rhabdoviruses is not dependent on host proteins TGS101 and VPS4A.
Vesicular Stomatitis
ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response.
Vesicular Stomatitis
Smurf1 restricts the antiviral function mediated by USP25 through promoting its ubiquitination and degradation.
Virus Diseases
Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.
Virus Diseases
E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3.
Virus Diseases
E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3.
Virus Diseases
E3 Ubiquitin Ligase Nedd4 Promotes Japanese Encephalitis Virus Replication by Suppressing Autophagy in Human Neuroblastoma Cells.
Virus Diseases
Human microRNA-30 inhibits influenza virus infection by suppressing the expression of SOCS1, SOCS3, and NEDD4.
Virus Diseases
Huwe1, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity.
Virus Diseases
Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense.
Virus Diseases
The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.
von Hippel-Lindau Disease
Human disorders of ubiquitination and proteasomal degradation.
Wolfram Syndrome
The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum.
Xeroderma Pigmentosum
Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation.
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