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Literature summary for 2.3.2.26 extracted from

  • Xu, Y.; Anderson, D.; Ye, Y.
    The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation (2016), Cell Discov., 2, 16040 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.26

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q7Z6Z7 isoform Huwe1
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [Ubl4A]-L-lysine Ubl4A, i.e. subunit of the Bag6 chaperone holdase complex. HUWE1 degrades unassembled Ubl4A in the cytoplasm Homo sapiens [E2 ubiquitin-conjugating enzyme]-L-cysteine + [Ubl4A]-N6-ubiquitinyl-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
Huwe1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function HUWE1 is a ubiquitin ligase for substrates bearing unshielded, hydrophobic segments. Many endogenous HUWE1 substrates form multi-protein complexes that function in the nucleus although HUWE1 itself is cytoplasmically localized. Inhibition of nuclear entry enhances HUWE1-mediated ubiquitination and degradation Homo sapiens