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Enzyme Kinetic Parameters
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Ligand [acceptor protein]-N6-ubiquitinyl-L-lysine

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Basic Ligand Information

Molecular Formula

BRENDA Name

InChIKey

[acceptor protein]-N6-ubiquitinyl-L-lysine

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (9 results)

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Show Natural Product (9 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.31

[E2 ubiquitin-conjugating enzyme cullin-1]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme cullin-1]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme cullin-2]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme cullin-2]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme cullin-3]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme cullin-3]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme cullin-4A]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme cullin-4A]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme cullin-5]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme cullin-5]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme UbcH5]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme UbcH5]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme UBCH7]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme UBCH7]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [RBR-type E3 ubiquitin transferase]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

9 entries

Substrate in Enzyme-catalyzed Reactions (9 results)

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EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.B12

[CHIP U-box-E4-ubiquitin-carrier protein Ubc4]-S-ubiquitinyl-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine = [CHIP U-box-E4-ubiquitin-carrier protein Ubc4]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-ubiquitinyl-L-lysine

726851

2.3.2.B12

[CHIP U-box-E4-ubiquitin-carrier protein UbH5C4]-S-ubiquitinyl-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine = [CHIP U-box-E4-ubiquitin-carrier protein UbcH5C]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-ubiquitinyl-L-lysine

726851

2.3.2.B12

[CYC4 U-box-E4-ubiquitin-carrier protein Ubc2B]-S-ubiquitinyl-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine = [CYC4 U-box-E4-ubiquitin-carrier protein Ubc2B]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-ubiquitinyl-L-lysine

726851

2.3.2.B12

[CYC4 U-box-E4-ubiquitin-carrier protein Ubc3]-S-ubiquitinyl-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine = [CYC4 U-box-E4-ubiquitin-carrier protein Ubc3]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-ubiquitinyl-L-lysine

726851

2.3.2.B12

[CYC4 U-box-E4-ubiquitin-carrier protein UbcH7]-S-ubiquitinyl-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine = [CYC4 U-box-E4-ubiquitin-carrier protein UbcH7]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-ubiquitinyl-L-lysine

726851

2.3.2.B12

[PRP19 U-box-E4-ubiquitin-carrier protein Ubc3]-S-ubiquitinyl-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine = [PRP19 U-box-E4-ubiquitin-carrier protein Ubc3]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-ubiquitinyl-L-lysine

726851

2.3.2.B12

[UFD2a U-box-E4-ubiquitin-carrier protein Ubc4]-S-ubiquitinyl-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine = [U-box-E4-ubiquitin-carrier protein]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-ubiquitinyl-L-lysine

726851

2.3.2.B12

[UFD2b U-box-E4-ubiquitin-carrier protein Ubc4]-S-ubiquitinyl-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine = [UFD2b U-box-E4-ubiquitin-carrier protein Ubc4]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-ubiquitinyl-L-lysine

726851

2.3.2.B12

[UFD2b U-box-E4-ubiquitin-carrier protein UbH5C]-S-ubiquitinyl-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine = [UFD2b U-box-E4-ubiquitin-carrier protein UbcH5C]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-ubiquitinyl-L-lysine

726851

2.3.2.B12

9 entries

Product in Enzyme-catalyzed Reactions (20 results)

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EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.26

[[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.27

[ACRE276-RING domain-E3-ubiquitin-carrier protein HubC5B]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [ACRE276-RING domain-E3-ubiquitin-carrier protein]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.27

[E2 ubiquitin-conjugating enzyme Ube2B]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme Ube2B]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.27

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [H2B]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.27

[PUB54-RING domain-ubiquitin-carrier protein Ubc13]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [PUB54-RING domain-ubiquitin-carrier protein Ubc13]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.27

[PUB54-RING domain-ubiquitin-carrier protein Ubc4/5]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [PUB54-RING domain-ubiquitin-carrier protein Ubc4/5]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.27

[TEB4-UBC7]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [TEB4-UBC7]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.27

[Ubc13]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [Ubc13]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme cullin-1]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme cullin-1]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme cullin-2]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme cullin-2]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme cullin-3]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme cullin-3]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme cullin-5]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme cullin-5]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme UbcH5C]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme UbcH5C]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme UbcH5]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme UbcH5]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme UBCH7]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme UBCH7]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [RBR-type E3 ubiquitin transferase]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[Ubc13]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [Ubc13]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

2.3.2.31

[UBCH5]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [UBCH5]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

Enzyme Kinetic Parameters

References & Links

Literature References (1)

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Show Reference (1 entry)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

726851

12646216

U-box proteins as a new family of ubiquitin ligases

2003

Hatakeyama, S.; Nakayama, K.I.

Biochem. Biophys. Res. Commun.

302

635-645

Links to other databases for [acceptor protein]-N6-ubiquitinyl-L-lysine

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EXTERNAL LINKS