Literature summary for 2.3.2.26 extracted from

Rossi, M.; Rotblat, B.; Ansell, K.; Amelio, I.; Caraglia, M.; Misso, G.; Bernassola, F.; Cavasotto, C.; Knight, R.; Ciechanover, A.; Melino, G.
High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy (2014), Cell Death Dis., 5, e935.

No PubMed abstract available

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Application

Application	Comment	Organism
medicine	antidepressant drug clomipramine specifically blocks ITCH auto-ubiquitylation, as well as p73 ubiquitylation. Treating a panel of breast, prostate and bladder cancer cell lines with clomipramine, or its homologs, leads to reduced cancer cell growth, and synergize with gemcitabine or mitomycin in killing cancer cells by blocking autophagy	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
chlorpromazine	minimum inhibitory concentration is 0.3 mM	Homo sapiens
chlorprothixene	minimum inhibitory concentration is 0.3 mM	Homo sapiens
clomipramine	antidepressant drug, specifically blocks isoform ITCH auto-ubiquitylation, as well as p73 ubiquitylation. Treating a panel of breast, prostate and bladder cancer cell lines with clomipramine, or its homologs, leads to reduced cancer cell growth, and synergize with gemcitabine or mitomycin in killing cancer cells by blocking autophagy. Minimum inhibitory concentration is 0.3 mM	Homo sapiens
norclomipramine	minimum inhibitory concentration is 0.3 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96J02	-	-

Synonyms

Synonyms	Comment	Organism
Itch	-	Homo sapiens

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Release 2023.1 (January 2023)