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Literature summary for 2.3.2.26 extracted from

  • Park, Y.; Yoon, S.K.; Yoon, J.B.
    TRIP12 functions as an E3 ubiquitin ligase of APP-BP1 (2008), Biochem. Biophys. Res. Commun., 374, 294-298.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14669
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[TRIP1-ubiquitin-conjugating enzyme E2]-S-ubiquitin-L-cysteine + [APP-BP1]-L-lysine ubiquitin ligase TRIP12 functions as an E3 enzyme of APP-BP1 and additionally requires an E4 activity for polyubiquitination of APP-BP1. APP-BP1 is part of the ubiquitin-like protein NEDD8 activating enzyme. TRIP12 specifically interacts with the APP-BP1 monomer but not with the APP-BP1/Uba3 heterodimer. Overexpression of TRIP12 enhances the degradation of APP-BP1, whereas knockdown of TRIP12 stabilizes it Homo sapiens [TRIP12-ubiquitin-conjugating enzyme E2]-L-cysteine + [APP-BP1]-N6-ubiquitinyl-L-lysine
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Synonyms

Synonyms Comment Organism
TRIP12
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Homo sapiens