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Ligand [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine

Basic Ligand Information

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Natural Substrate (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.31

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

744643

-

2.3.2.31

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RBR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine

744643

-

2.3.2.33

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine

754893

-

2.3.2.33

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine

754893

-

2.3.2.31

2 entries

2.3.2.33

2 entries

2.3.2.36

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine

760191

-

Substrate in Enzyme-catalyzed Reactions (15 results)

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Show Substrate (15 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.26

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [Dvl2]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [Dvl2]-N6-ubiquitinyl-L-lysine

757214

-

2.3.2.26

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [my-opioid receptor MOR1]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [my-opioid receptor MOR1]-N6-ubiquitinyl-L-lysine

755765

-

2.3.2.26

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [Spo12]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [Spo12]-N6-ubiquitinyl-L-lysine

756723

-

2.3.2.26

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [Ubl4A]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [Ubl4A]-N6-ubiquitinyl-L-lysine

756388

-

2.3.2.27

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [betaC1 protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [betaC1 protein]-N6-ubiquitinyl-L-lysine

757707

-

2.3.2.27

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [FANCD2]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [FANCD2]-N6-ubiquitinyl-L-lysine

755680

-

2.3.2.27

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [KAT1]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [KAT1]-N6-ubiquitinyl-L-lysine

757927

-

2.3.2.27

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [MLO12-Myc]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor MLO12-Myc]-N6-ubiquitinyl-L-lysine

757821

-

2.3.2.27

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [MYB1]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [MYB1]-N6-ubiquitinyl-L-lysine

757490

-

2.3.2.31

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine

744643

-

2.3.2.31

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RBR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine

744643

-

2.3.2.33

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine

754893

-

2.3.2.33

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [F-box protein FBXW7]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [F-box protein FBXW7]-3-O-ubiquitinyl-L-threonine

753182

-

2.3.2.33

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine

753182, 754893

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2.3.2.26

4 entries

2.3.2.27

5 entries

2.3.2.31

2 entries

2.3.2.33

3 entries

2.3.2.36

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine

760191

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Enzyme Kinetic Parameters

References & Links

Literature References (13)

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Show Reference (13 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

744643

-

Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation

2016

Scott, D.; Rhee, D.; Duda, D.; Kelsall, I.; Olszewski, J.; Paulo, J.; de Jong, A.; Ovaa, H.; Alpi, A.; Harper, J.; Schulman, B.

Cell

166

1198-1214

753182

31285543

FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation

2019

Richter, K.T.; Kschonsak, Y.T.; Vodicska, B.; Hoffmann, I.

Cell Death Differ.

27

758-772

754893

29643511

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

2018

Pao, K.C.; Wood, N.T.; Knebel, A.; Rafie, K.; Stanley, M.; Mabbitt, P.D.; Sundaramoorthy, R.; Hofmann, K.; van Aalten, D.M.F.; Virdee, S.

Nature

556

381-385

755680

28535027

Arsenite binds to the RING finger domain of FANCL E3 ubiquitin ligase and inhibits DNA interstrand crosslink repair

2017

Jiang, J.; Bellani, M.; Li, L.; Wang, P.; Seidman, M.M.; Wang, Y.

ACS Chem. Biol.

12

1858-1866

755765

30758996

The HECT ubiquitin E3 ligase Smurf2 degrades my-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells

2019

Dong, S.; Liu, J.; Li, L.; Wang, H.; Ma, H.; Zhao, Y.; Zhao, J.

Am. J. Physiol. Cell Physiol.

316

C632-C640

756388

27867533

The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation

2016

Xu, Y.; Anderson, D.; Ye, Y.

Cell Discov.

2

16040

756723

29683484

The HECT-type ubiquitin ligase Tom1 contributes to the turnover of Spo12, a component of the FEAR network, in G2/M phase

2018

Nakatsukasa, K.; Sone, M.; Alemayehu, D.; Okumura, F.; Kamura, T.

FEBS Lett.

592

1716-1724

757214

29463679

Substrate clustering potently regulates the activity of WW-HECT domain-containing ubiquitin ligases

2018

Mund, T.; Pelham, H.

J. Biol. Chem.

293

5200-5209

757490

29016961

Apple RING finger E3 ubiquitin ligase MdMIEL1 negatively regulates salt and oxidative stresses tolerance

2017

An, J.; Liu, X.; Song, L.; You, C.; Wang, X.; Hao, Y.

J. Plant Biol.

60

137-145

757707

27018391

Tobacco RING E3 ligase NtRFP1 mediates ubiquitination and proteasomal degradation of a geminivirus-encoded betaC1

2016

Shen, Q.; Hu, T.; Bao, M.; Cao, L.; Zhang, H.; Song, F.; Xie, Q.; Zhou, X.

Mol. Plant

9

911-925

757821

29932218

EMR, a cytosolic-abundant ring finger E3 ligase, mediates ER-associated protein degradation in Arabidopsis

2018

Park, J.H.; Kang, C.H.; Nawkar, G.M.; Lee, E.S.; Paeng, S.K.; Chae, H.B.; Chi, Y.H.; Kim, W.Y.; Yun, D.J.; Lee, S.Y.

New Phytol.

220

163-177

757927

28766720

Molecular characterization of rice arsenic-induced RING finger E3 ligase 2 (OsAIR2) and its heterogeneous overexpression in Arabidopsis thaliana

2017

Hwang, S.G.; Chapagain, S.; Han, A.R.; Park, Y.C.; Park, H.M.; Kim, Y.H.; Jang, C.S.

Physiol. Plant.

161

372-384

760191

15994556

Biochemistry Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase

2005

Cadwell, K.; Coscoy, L.

Science

309

127-130

Links to other databases for [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine

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Show Links (1 entry)