Literature summary for 2.3.2.26 extracted from

Liu, Y.; HuangFu, W.; Huang, H.; Wu, W.; Chen, Y.; Yen, Y.; Huang, H.; Nien, C.; Lai, M.; Pan, S.; Liou, J.
1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma (2017), Eur. J. Med. Chem., 140, 84-91 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-[[(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino]methyl]-N-(pyridin-4-yl)benzamide	compound exhibits remarkable anticancer activity with tumor growth inhibition values of 98.3% and 100% at 25 mg/kg and 50 mg/kg orally daily, respectively, against human RPMI-8226 multiple myeloma xenograft. Treatment with the compound also shows a decrease of Itch level in human RPMI-8226 multiple myeloma cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96J02	isoform Itch	-

Synonyms

Synonyms	Comment	Organism
Itch	-	Homo sapiens

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Release 2023.1 (January 2023)