Application | Comment | Organism |
---|---|---|
medicine | functional interaction of NEDD4-like ubiquitin protein ligase NEDL1 with p53 might contribute to the induction of apoptosis in cancerous cells bearing wild-type p53 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q76N89 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
NEDL1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | NEDD4-like ubiquitin protein ligase NEDL1 cooperates with p53 to induce apoptosis. During cisplatin -mediated apoptosis in neuroblastoma SH-SY5Y cells, p53 is induced to accumulate in association with an increase in expression levels of NEDL1. Enforced expression of NEDL1 results in a decrease in number of G418-resistant colonies in SH-SY5Y and U2OS cells bearing wild-type p53, whereas NEDL1 had undetectable effect on p53-deficient H1299 and SAOS-2 cells. Enforced expression of NEDL1 increases the number of U2OS cells with sub-G1 DNA content. NEDL1 binds to the COOH-terminal region of p53 and has an ability to enhance the transcriptional activity of p53. Small interfering RNA-mediated knockdown of the endogenous NEDL1 confers the resistance of U2OS cells to adriamycin. NEDL1 enhances pro-apoptotic activity of p53 in its catalytic activity-independent manner | Homo sapiens |