Literature summary for 2.3.2.26 extracted from

Braganza, A.; Li, J.; Zeng, X.; Yates, N.; Dey, N.; Andrews, J.; Clark, J.; Zamani, L.; Wang, X.; St Croix, C.; OSullivan, R.; Garcia-Exposito, L.; Brodsky, J.; Sobol, R.
UBE3B is a calmodulin-regulated, mitochondrion-associated E3 ubiquitin ligase (2017), J. Biol. Chem., 292, 2470-2484 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
Ca2+	when the concentration of calcium is increased, calmodulin is released from UBE3B, resulting in an increase in ubiquitylation activity	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C1036A	loss of ubiquitylation activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Calmodulin	UBE3B interacts with calmodulin via its N-terminal isoleucine-glutamine motif. Deletion of the motif (amino acids 29-58) results in loss of calmodulin binding and a significant increase in the in vitro ubiquitylation activity of UBE3B. Changes in calcium levels in vitro disrupt the calmodulin-UBE3B interaction	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	mitochondrion-associated protein	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q7Z3V4	isoform UBE3B	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	UBE3B shows HECT E3 ubiquitin ligase activity and exhibits time-dependent auto-ubiquitylation activity	Homo sapiens	?	-	-

Synonyms

Synonyms	Comment	Organism
UBE3B	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	mutating the catalytic cysteine or deleting the entire HECT domain (amino acids 758-1068) results in loss of UBE3B's ubiquitylation activity. Knockdown of UBE3B in human cells induces changes in mitochondrial morphology and physiology, a decrease in mitochondrial volume, and a severe suppression of cellular proliferation	Homo sapiens

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Release 2023.1 (January 2023)