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Literature summary for 2.3.2.26 extracted from

  • Ding, Y.; Zhang, Y.; Xu, C.; Tao, Q.H.; Chen, Y.G.
    HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation (2013), J. Biol. Chem., 288, 8289-8298.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96PU5 isoform 2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-(ubiquitin)n-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [Dvl2]-L-lysine Dvl2 i.e. dishevelled, a central mediator for both Wnt/beta-catenin and Wnt/planar cell polarity pathways Homo sapiens [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-(ubiquitin)n-[Dvl2]-L-lysine isoform NEDD4L mediates polyubiquitination of Dvl2 at Lys6, Lys27, and Lys29 ?

Synonyms

Synonyms Comment Organism
Nedd4L
-
Homo sapiens

General Information

General Information Comment Organism
physiological function isoform NEDD4L induces Dvl2 polyubiquitination and targets Dvl2 for proteasomal degradation, thereby regulating the cellular beta-catenin level and Rac1, RhoA, and JNK activities Homo sapiens