Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96PU5 | isoform 2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-(ubiquitin)n-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [Dvl2]-L-lysine | Dvl2 i.e. dishevelled, a central mediator for both Wnt/beta-catenin and Wnt/planar cell polarity pathways | Homo sapiens | [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-(ubiquitin)n-[Dvl2]-L-lysine | isoform NEDD4L mediates polyubiquitination of Dvl2 at Lys6, Lys27, and Lys29 | ? |
Synonyms | Comment | Organism |
---|---|---|
Nedd4L | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform NEDD4L induces Dvl2 polyubiquitination and targets Dvl2 for proteasomal degradation, thereby regulating the cellular beta-catenin level and Rac1, RhoA, and JNK activities | Homo sapiens |