Literature summary for 2.3.2.26 extracted from

Tran, H.; Bustos, D.; Yeh, R.; Rubinfeld, B.; Lam, C.; Shriver, S.; Zilberleyb, I.; Lee, M.W.; Phu, L.; Sarkar, A.A.; Zohn, I.E.; Wertz, I.E.; Kirkpatrick, D.S.; Polakis, P.
HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction (2013), J. Biol. Chem., 288, 3753-3767.

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Protein Variants

Protein Variants	Comment	Organism
C2579G	mutation in catalytic cysteine, loss of E3 ligase activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-
HEK-293T cell	-	Homo sapiens	-
hTERT-RPE1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-(ubiquitin)n-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [adenomatous polyposis coli]-L-lysine	adenomatous polyposis coli protein functions as a negative regulator of the Wnt signaling pathway	Homo sapiens	[E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-(ubiquitin)n-[adenomatous polyposis coli]-L-lysine	isoform HECTD1 modifies adenomatous polyposis coli with Lys63 polyubiquitin	?

General Information

General Information	Comment	Organism
physiological function	isoform HectD1 promotes the adenomatous polyposis coli-axin interaction to negatively regulate Wnt signaling. Knockdown of HectD1 diminishes adenomatous polyposis coli ubiquitylation, disrupts the adenomatous polyposis coli-axin interaction, and augments Wnt3a-induced beta-catenin stabilization and signaling	Homo sapiens

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Release 2023.1 (January 2023)