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3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
3,3',5,5'-tetraiodo-L-thyronine + AH2
?
-
-
-
?
3,3',5-triiodo-L-thyronine sulfate + reduced electron acceptor
diiodothyronine + iodide + electron acceptor
-
-
-
?
3,3',5-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
3,3',5-triiodothyronine + AH2
3,5-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5-triiodothyronine + AH2
diiodothyronine + iodide + A + H+
rT3 ORD activity
-
-
?
3,5'-diiodo-L-thyronine + AH2
3-iodothyronine + iodide + A + H+
-
-
-
-
?
3,5,3'-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
assay at pH 7.2
-
-
?
L-3,5',3'-triiodothyronine + AH2
L-3,3'-diiodothyronine + iodide + A + H+
L-3,5'-diiodothyonine + AH2
L-3-iodothyronine + iodide + A + H+
-
-
-
-
?
L-3,5'-diiodothyronine + AH2
L-3-iodothyronine + iodide + A + H+
-
-
-
-
?
L-3,5,3',5'-tetraiodothyronine + AH2
L-3,5,3'-triiodothyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + electron acceptor
3,3',5-triiodothyronine + iodide + reduced electron acceptor
L-thyroxine + reduced acceptor
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
reverse triiodothyronine + AH2
diiodothyronine + iodide + A + H+
sulfated reverse triiodothyronine + AH2
diiodothyronine + iodide + A + H+ + ?
-
-
-
-
?
additional information
?
-
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I, degradation of 3,3',5'-triiodo-L-thyronine
hormonally inactive
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I, degradation of 3,3',5'-triiodo-L-thyronine
hormonally inactive
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
the reaction is catalyzed by the type 1 and 2 deiodinases
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I: degradation of 3,3',5'-triiodo-L-thyronine
hormonally inactive
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I: degradation of 3,3',5'-triiodo-L-thyronine
hormonally inactive
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I, degradation of 3,3',5'-triiodo-L-thyronine
hormonally inactive
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
isoenzyme type I
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
substrate for type 1 iodothyronine deiodinase
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
isoenzyme type I
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
rT3 ORD activity
-
-
?
3,3',5-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
isoenzyme type II and type III
-
-
?
L-3,5',3'-triiodothyronine + AH2
L-3,3'-diiodothyronine + iodide + A + H+
-
5'-deionination by isozyme Dio1
-
-
?
L-3,5',3'-triiodothyronine + AH2
L-3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
L-3,5,3',5'-tetraiodothyronine + AH2
L-3,5,3'-triiodothyronine + iodide + A + H+
-
i.e. thyroxine
triiodothyrosine, a small 3,3'-T2 peak also occurs
-
?
L-3,5,3',5'-tetraiodothyronine + AH2
L-3,5,3'-triiodothyronine + iodide + A + H+
-
i.e. thyroxine
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
isoenzyme Dio1
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
idothyronine 5'-deiodinase type I
-
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
type II
-
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
thyronine 5-deiodinase type
-
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
idothyronine 5'-deiodinase type I
-
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type II
hormonally active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type II
hormonally active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type II
hormonally active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type II
hormonally active
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
outer ring iodothyronine deiodinase activity, T4 ORD activity
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
reaction with dithiothreitol
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
thyronine 5'-deiodinase type II
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
in kidney and liver cells the enzyme can serve as an enzymic barrier to the entry of the prohormone thyroxine and the source of bioactive 3,3',5-triiodothyronine for the cell
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
thyronine 5'-deiodinase type II
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
addition of I125 labelled T4 to measure the production of T3
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
activation and deactivation of thyroid hormone
-
-
r
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
the reaction is catalyzed by the type 1 and 2 deiodinases
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
r
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
assay at pH 7.2
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type II
hormonally active
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
addition of I125 labelled T4 to measure the production of T3, using paper chromatography
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
substrate for type 2 iodothyronine deiodinase
-
-
?
L-thyroxine + electron acceptor
3,3',5-triiodothyronine + iodide + reduced electron acceptor
-
-
-
?
L-thyroxine + electron acceptor
3,3',5-triiodothyronine + iodide + reduced electron acceptor
the enzyme is regulated at the pretranslational level
-
-
?
L-thyroxine + electron acceptor
3,3',5-triiodothyronine + iodide + reduced electron acceptor
-
-
-
?
L-thyroxine + reduced acceptor
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
-
-
-
?
L-thyroxine + reduced acceptor
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
-
-
?
reverse triiodothyronine + AH2
diiodothyronine + iodide + A + H+
-
-
-
-
?
reverse triiodothyronine + AH2
diiodothyronine + iodide + A + H+
-
-
-
r
reverse triiodothyronine + AH2
diiodothyronine + iodide + A + H+
-
-
-
-
?
additional information
?
-
-
selenium-level of cells influences the enzyme activity
-
-
?
additional information
?
-
-
the catalytic cycle of ID-1 involves a ping-pong bisubstrate reaction in which the selenol form of the enzyme (ESeH) reacts with L-thyroxine to form a selenenyl iodide intermediate (ESeI) with release of the deiodinated compound 3,5,3'-triiodo-L-thyronine, and a subsequent reaction between the selenenyl iodide intermediate and possibly a thiol cofactor regenerates the selenol form
-
-
?
additional information
?
-
-
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
-
-
?
additional information
?
-
-
isozyme Dio1 exhibits both phenolic and tyrosyl ring deiodination activity while isozyme Dio2 catalyzes only deiodinations of the phenolic ring, isozyme Dio3 catalyzes only deiodinations of the tyrosyl ring. T3, 3,3'-T2, and 3,5-T2 are also not deiodinated by Dio1 from HepG2 lysates
-
-
?
additional information
?
-
-
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
-
-
?
additional information
?
-
-
L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
3,3',5-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
isoenzyme type II and type III
-
-
?
3,3',5-triiodothyronine + AH2
3,5-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,5'-diiodo-L-thyronine + AH2
3-iodothyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + electron acceptor
3,3',5-triiodothyronine + iodide + reduced electron acceptor
the enzyme is regulated at the pretranslational level
-
-
?
L-thyroxine + reduced acceptor
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
-
-
-
?
additional information
?
-
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
isoenzyme type I
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
isoenzyme type I
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
isoenzyme Dio1
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
idothyronine 5'-deiodinase type I
-
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
idothyronine 5'-deiodinase type I
-
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
thyronine 5'-deiodinase type II
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
in kidney and liver cells the enzyme can serve as an enzymic barrier to the entry of the prohormone thyroxine and the source of bioactive 3,3',5-triiodothyronine for the cell
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
thyronine 5'-deiodinase type II
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
activation and deactivation of thyroid hormone
-
-
r
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
r
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
additional information
?
-
-
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
-
-
?
additional information
?
-
-
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
-
-
?
additional information
?
-
-
L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway
-
-
?
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(2E)-2-(3,4-dihydroxybenzylidene)-4,6-dihydroxy-1-benzofuran-3(2H)-one
-
aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11
(2E)-2-(3,4-dihydroxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one
-
aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11
(2E)-4,6-dihydroxy-2-(4-hydroxy-3-iodobenzylidene)-1-benzofuran-3(2H)-one
-
aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11
(2E)-4,6-dihydroxy-2-(4-hydroxybenzylidene)-1-benzofuran-3(2H)-one
-
aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11
(4-[(E)-(4,6-dihydroxy-3-oxo-1-benzofuran-2(3H)-ylidene)methyl]phenoxy)acetic acid
-
aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11
2-(3,4-dihydroxybenzyl)-4,6-dihydroxy-1-benzofuran-3(2H)-one
-
aurone derivative isolated from plant extract. Comparison with inhibition of 5-deiodinase EC 1.97.1.11
2-amino-3-[4-[(4-hydroxy-3,5-diiodophenyl)thio]-3,5-diiodophenyl]propanoic acid
-
comparison with 5-deiodinase EC 1.97.1.11
3',5'-diiodothyronine
-
comparison with 5-deiodinase EC 1.97.1.11
3,3',5'-triiodo-L-thyronine
3,3',5'-triiodothyronine
-
comparison with 5-deiodinase EC 1.97.1.11
3,3',5,5'-tetraiodo-L-thyronine
-
hypoxia has no effect on inhibition of T4
3,5,3'-triiodo-5'-nitrothyronine
-
comparison with 5-deiodinase EC 1.97.1.11
3,5,5'-triiodo-2'-methylthyronine
-
comparison with 5-deiodinase EC 1.97.1.11
3,5-diiodo-2'-hydroxythyronine
-
comparison with 5-deiodinase EC 1.97.1.11
3,5-diiodo-3',5'-dinitrothyronine
-
comparison with 5-deiodinase EC 1.97.1.11
3,5-diiodo-3'-hydroxythyronine
-
comparison with 5-deiodinase EC 1.97.1.11
3,5-diiodo-4'-amino-3',5'-dimethylthyronine
-
comparison with 5-deiodinase EC 1.97.1.11
Ca2+
-
inhibits expression of isozyme type I in thyroid gland
coumarin
-
anticoagulants
dexamethasone
-
inhibits expression of isozyme type I
ethyl 4-(4-hydroxy-3,5-diiodobenzoyl)phenyl carbonate
-
comparison with 5-deiodinase EC 1.97.1.11
Insulin
-
inhibits enzyme expression in glial cell culture
-
interleukin 1 and interleukin 6
-
interleukins are competing for transcriptional coactivators and inhibit thyronine 5'-deiodinase induction by 3,3',5-triiodothyronine
-
L-thyroxine
-
isozyme type II
N-acetyl-3,5,3'-triiodo-5'-nitrothyronine
-
comparison with 5-deiodinase EC 1.97.1.11
N-acetyl-3,5-diiodo-3',5'-dinitrothyronine
-
comparison with 5-deiodinase EC 1.97.1.11
N-acetyl-3,5-diiodo-3'-bromo-5'-nitrothyronine
-
comparison with 5-deiodinase EC 1.97.1.11
N-bromoacetyl-L-thyroxine
-
i.e. BrAc-3,3',5-triiodothyronine, all isoenzymes
SH-group blocking reagents
-
-
-
Soybean phospholipids
-
competition with microsomal lipids
-
Tetraiodothyroacetic acid
-
comparison with 5-deiodinase EC 1.97.1.11
thyroxine
-
isozyme type II, rapid inactivation in brain
[4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid
-
comparison with 5-deiodinase EC 1.97.1.11
[4-(4-hydroxy-3,5-dinitrophenoxy)-3,5-diiodophenyl]acetic acid
-
comparison with 5-deiodinase EC 1.97.1.11
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)-3,5-diiodophenyl]acetic acid
-
comparison with 5-deiodinase EC 1.97.1.11
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)phenyl]acetic acid
-
comparison with 5-deiodinase EC 1.97.1.11
3,3',5'-triiodo-L-thyronine
-
-
3,3',5'-triiodo-L-thyronine
-
isozyme type II, rapid inactivation in brain
3,3',5'-triiodo-L-thyronine
-
inhibits expression of isozyme type II
6-Propyl-2-thiouracil
-
only type II sensitive to inhibition
6-Propyl-2-thiouracil
-
inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity
6-Propyl-2-thiouracil
-
competes with thiol cofactor; type I mutant with exchange of selenocysteine by cystein is 300fold less sensitive
6-Propyl-2-thiouracil
-
inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity
6-Propyl-2-thiouracil
-
-
6-Propyl-2-thiouracil
-
inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity
aurothioglucose
-
type I, selenium-containing enzyme, competitive
aurothioglucose
-
type I, selenium-containing enzyme, competitive
aurothioglucose
-
type I, selenium-containing enzyme, competitive
aurothioglucose
-
type I, selenium-containing enzyme, competitive
aurothioglucose
-
type I, selenium-containing enzyme, competitive
aurothioglucose
-
type I, selenium-containing enzyme, competitive
aurothioglucose
-
competitive
aurothioglucose
-
type I, selenium-containing enzyme, competitive
aurothioglucose
-
type I, selenium-containing enzyme, competitive
aurothioglucose
-
isoyzme type I
iodoacetate
-
iodoacetate
-
isozyme type I
iopanoic acid
-
both isozyme type I and type II
iopanoic acid
-
both isozyme type I and type II
ipanoic acid
-
-
propylthiouracil
-
-
propylthiouracil
-
native and recombinant enzyme, IC50: 0.005-0.01 mM
propylthiouracil
wild-type and mutant enzymes A131C and A131S are insensitive to propylthiouracil in presence ogf 20 mM dithiothreitol. When tested in presence of 0.2 mM dithiothreitol the Ic50 value for propylthiouracil is reduced to about 0.1 mM
propylthiouracil
-
D1 inhibitor
propylthiouracil
-
partially, uncompetitively
propylthiouracil
-
isozyme type I
additional information
-
no inhibition by propylthiouracil, type II-like enzyme
-
additional information
-
expression and function of the 5-deiodinase and 5-deiodinase isozymes are sensitive to thyroid hormone status, various cytokines and growth factors, severe illness, reactive oxygen species, a variety of hormones and signaling compounds, circadian rythm, and pharmacological agents, and therefore might be useful in sensor function of physiology and pathophysiology
-
additional information
substrate-induced loss of activity of the type 2 deiodinase is due to proteasomal degradation of the enzyme and requires interaction with the catalytic center
-
additional information
-
substrate-induced loss of activity of the type 2 deiodinase is due to proteasomal degradation of the enzyme and requires interaction with the catalytic center
-
additional information
-
the wild type enzyme is insensitive to 6-propyl-2-thiouracil
-
additional information
no inhibition by propylthiouracil
-
additional information
-
no inhibition by propylthiouracil
-
additional information
-
lipopolysaccharide-induced type 2 deiodinase activity is not inhibited by 1 mM 6-propyl-2-thiouracil
-
additional information
-
3,3',5'-triiodothyronine blocks 5'-deiodination of L-thyroxine blocks 5'-deiodination of 3,3',5'-triiodothyronine
-
additional information
-
L-thyroxine inhibited competitively 3,3',5'-triiodothyronine utilization of isoenzyme type II
-
additional information
-
3,3',5'-triiodothyronine blocks 5'-deiodination of L-thyroxine blocks 5'-deiodination of 3,3',5'-triiodothyronine
-
additional information
-
3,3',5'-triiodothyronine blocks 5'-deiodination of L-thyroxine blocks 5'-deiodination of 3,3',5'-triiodothyronine
-
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Goswami, A.; Leonard, J.L.; Rosenberg, I.N.
Inhibition by coumardin anticoagulants of enzymatic outer ring monodeiodination of iodothyronines
Biochem. Biophys. Res. Commun.
104
1231-1238
1982
Rattus sp.
brenda
Koehrle, J.; Auf'mkolk, M.; Rokos, H.; Hesch, R.D.; Cody, V.
Rat liver iodothyronine monodeiodinase. Evaluation of the iodothyronine ligand-binding site
J. Biol. Chem.
261
11613-11622
1986
Rattus norvegicus
brenda
Auf'mkolk, M.; Koehrle, J.; Hesch, R.D.; Cody, V.
Inhibition of rat liver iodothyronine deiodinase. Interaction of aurones with the iodothyronine ligand-binding site
J. Biol. Chem.
261
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1986
Rattus norvegicus
brenda
Leonard, J.L.; Rosenberg, I.N.
Solubilization of a phospholipid-requiring enzyme, iodothyronine 5-deiodinase, from rat kidney membranes
Biochim. Biophys. Acta
659
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1981
Rattus sp.
brenda
Colquhoun, E.Q.; Thomson, R.M.
Lysosomal thyroid hormone 5-deiodinase
FEBS Lett.
177
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1984
Rattus sp.
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Visser, T.J.
Deiodination of thyroid hormone and the role of glutathione
Trends Biochem. Sci.
5
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1980
Rattus sp.
-
brenda
Auf dem Brinke, D.; Hesch, R.D.; Khrle, J.
Re-examination of the subcellular localization of thyroxine 5-deiodination in rat liver
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180
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1979
Rattus norvegicus
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Ericksen, V.J.; Cavalieri, R.R.; Rosenberg, L.L.
Phenolic and nonphenolic ring iodothyronine deiodinases from rat thyroid gland
Endocrinology
108
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Rattus sp.
brenda
Leonard, J.L.; Siegrist-Kaiser, C.A.; Zuckerman, C.J.
Regulation of type II iodothyronine 5'-deiodinase by thyroid hormone
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Rattus sp.
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Leonard, D.M.; Stachelek, S.J.; Safran, M.; Farwell, A.P.; Kowalik, T.F.; Leonard, J.L.
Cloning, expression, and functional characterization of the substrate binding subunit of rat type II iodothyroine 5'-deiodinase
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275
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2000
Rattus sp.
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Yu, J.; Koenig, R.J.
Regulation of hepatocyte thyroxine 5'-deiodinase by T3 and nuclear receptor coactivators as a model of the sick euthyroid syndrome
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275
38296-38301
2000
Homo sapiens, Mus musculus, Rattus sp.
brenda
Sharifi, J.; St.Germain, D.L.
The cDNA for the type I iodothyroine 5'-deiodinase encodes an enzyme manifesting both high KM and low KM activity
J. Biol. Chem.
267
12539-12544
1992
Rattus sp.
brenda
Safran, M.; Leonard, J.L.
Comparison of the physicochemical properties of type I and type II iodothyroine 5'-deiodinase
J. Biol. Chem.
266
3233-3238
1991
Rattus sp.
brenda
Berry, M.J.; Kieffer, J.D.; Harney, J.W.; Larsen, P.R.
Selenocysteine confers the biochemical properties charateristic of the type I iodothyronine deiodinase
J. Biol. Chem.
266
14155-14158
1991
Rattus sp.
brenda
Garcia-Macias, J.F.; Molinero, P.; Guerrero, J.M.; Osuna, C.
Expression of type II thyroxine 5'-deiodinase from rat harderian gland in Xenopus laevis oocytes
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354
110-112
1994
Homo sapiens, Rattus sp.
brenda
Orozco, A.; Silva, J.E.; Valverde-R, C.
Rainbow trout liver expresses two iodothyronine phenolic ring deiodinase pathways with the characteristics of mammalian types I and II 5'-deiodinases
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138
254-258
1997
Gallus gallus, Oncorhynchus mykiss, Lithobates catesbeianus, Rattus sp.
brenda
Burmeister, L.A.; Pachucki, J.; St.Germain, D.L.
Thyroid hormones inhibit type 2 iodothyronine deiodinase in the rat cerebral cortex by both pre- and posttranslational mechanisms
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138
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1997
Rattus sp.
brenda
Santini, F.; Chopra, I.J.; Hurd, R.E.; Chua Teco, G.N.
A study of the characteristics of hepatic iodothyronine 5'-monodeiodinase in various vertebrate species
Endocrinology
131
830-834
1992
Bos taurus, Cavia porcellus, Gallus gallus, Ovis aries, Homo sapiens, Mus musculus, Rattus sp., Sus scrofa
brenda
Santini, F.; Chopra, I.J.; Hurd, R.E.; Solomon, D.H.; Chua Teco, G.N.
A study of the characteristics of the rat placental iodothyronine 5'-monodeiodinase: evidence that it is distinct from the rat hepatic iodothyronine 5'-monoiodinase
Endocrinology
130
2325-2332
1992
Rattus norvegicus
brenda
Mori, Y.; Nishikawa, M.; Toyoda, N.; Yonemoto, T.; Matsubara, H.; Inada, M.
Iodothyronine 5'-deiodinase activity in cultured rat myocardial cells: characteristics and effects of triiodothyronine and angiotensin II
Endocrinology
128
3105-3112
1991
Rattus sp.
brenda
Molinero, P.; Osuna, C.; Guerrero, J.M.
Type II thyroxine 5'-deiodinase in the rat thymus
J. Endocrinol.
146
105-111
1995
Rattus sp.
brenda
Osuna, C.; Orta, J.M.; Rubio, A.; Molinero, P.; Guerrero, J.M.
Thyroxine type II 5'-deiodinase activity in pineal and harderian glands is enhanced by hypothyroidism but is independent of serum thyroxine concentrations during hyperthyroidism
Int. J. Biochem.
25
1041-1046
1993
Rattus sp.
brenda
Goswami, A.; Rosenberg, I.N.
Reconstitution of a purified and partially active low KM iodothyronine 5'-deiodinase with phospholipids
Biochem. Int.
27
257-263
1992
Rattus sp.
brenda
Darras, V.M.; Berghman, L.R.; Vanderpooten, A.; Kuhn, E.R.
Growth hormone acutely decreases type III iodothyronine deiodinase in chicken liver
FEBS Lett.
310
5-8
1992
Gallus gallus
brenda
Bates, J.M.; Spate, V.L.; Morris, J.S.; St.Germain, D.L.; Galton, V.A.
Effects of selenium deficiency on tissue selenium content, deiodinase activity, and thyroid hormone economy in the rat during development
Endocrinology
141
2490-2500
2000
Rattus norvegicus
brenda
Koehrle, J.
Iodothyronine deiodinases
Methods Enzymol.
347
125-167
2002
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus, vertebrata
brenda
Steinsapir, J.; Bianco, A.C.; Buettner, C.; Harney, J.; Larsen, P.R.
Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center
Endocrinology
141
1127-1135
2000
Homo sapiens (Q92813), Homo sapiens
brenda
Buettner, C.; Harney, J.W.; Larsen, P.R.
The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase
Endocrinology
141
4606-4612
2000
Homo sapiens (Q92813), Homo sapiens
brenda
Kuiper, G.G.; Klootwijk, W.; Visser, T.J.
Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor
Endocrinology
143
1190-1198
2002
Homo sapiens (Q92813), Homo sapiens
brenda
Kuiper, G.G.; Wassen, F.; Klootwijk, W.; Van Toor, H.; Kaptein, E.; Visser, T.J.
Molecular basis for the substrate selectivity of cat type I iodothyronine deiodinase
Endocrinology
144
5411-5421
2003
Felis catus
brenda
Curcio-Morelli, C.; Gereben, B.; Zavacki, A.M.; Kim, B.W.; Huang, S.; Harney, J.W.; Larsen, P.R.; Bianco, A.C.
In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases
Endocrinology
144
937-946
2003
Homo sapiens (P49895), Homo sapiens (Q92813), Homo sapiens
brenda
Shepherdley, C.A.; Richardson, S.J.; Evans, B.K.; Kuehn, E.R.; Darras, V.M.
Characterization of outer ring iodothyronine deiodinases in tissues of the saltwater crocodile (Crocodylus porosus)
Gen. Comp. Endocrinol.
125
387-398
2002
Crocodylus porosus
brenda
Brzezinska-Slebodzinska, E.; Slebodzinski, A.B.; Kowalska, K.
Evidence for the presence of 5'-deiodinase in mammalian seminal plasma and for the increase in enzyme activity in the prepubertal testis
Int. J. Androl.
23
218-224
2000
Sus scrofa
brenda
Leonard, J.L.; Visser, T.J.; Leonard, D.M.
Characterization of the subunit structure of the catalytically active type I iodothyronine deiodinase
J. Biol. Chem.
276
2600-2607
2001
Rattus norvegicus (P24389)
brenda
Curcio, C.; Baqui, M.M.; Salvatore, D.; Rihn, B.H.; Mohr, S.; Harney, J.W.; Larsen, P.R.; Bianco, A.C.
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line
J. Biol. Chem.
276
30183-30187
2001
Homo sapiens (Q92813), Homo sapiens
brenda
Verhoelst, C.H.; Van Der Geyten, S.; Darras, V.M.
Renal and hepatic distribution of type I and type III iodothyronine deiodinase protein in chicken
J. Endocrinol.
181
85-90
2004
Gallus gallus, Gallus gallus (O42411)
brenda
Kuiper, G.G.; Klootwijk, W.; Visser, T.J.
Expression of recombinant membrane-bound type I iodothyronine deiodinase in yeast
J. Mol. Endocrinol.
34
865-878
2005
Rattus norvegicus (P24389)
brenda
Song, S.; Sorimachi, K.; Adachi, K.; Oka, T.
Biochemical and molecular biological evidence for the presence of type II iodothyronine deiodinase in mouse mammary gland
Mol. Cell. Endocrinol.
160
173-181
2000
Mus musculus (Q9Z1Y9), Mus musculus
brenda
Yasuo, S.; Yoshimura, T.; Ebihara, S.; Korf, H.W.
Temporal dynamics of type 2 deiodinase expression after melatonin injections in Syrian hamsters
Endocrinology
148
4385-4392
2007
Mesocricetus auratus
brenda
Lamirand, A.; Mercier, G.; Ramauge, M.; Pierre, M.; Courtin, F.
Hypoxia stabilizes type 2 deiodinase activity in rat astrocytes
Endocrinology
148
4745-4753
2007
Rattus norvegicus
brenda
Fekete, C.; Freitas, B.C.; Zeoeld, A.; Wittmann, G.; Kadar, A.; Liposits, Z.; Christoffolete, M.A.; Singru, P.; Lechan, R.M.; Bianco, A.C.; Gereben, B.
Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain
Endocrinology
148
4865-4874
2007
Rattus norvegicus
brenda
Kanou, Y.; Hishinuma, A.; Tsunekawa, K.; Seki, K.; Mizuno, Y.; Fujisawa, H.; Imai, T.; Miura, Y.; Nagasaka, T.; Yamada, C.; Ieiri, T.; Murakami, M.; Murata, Y.
Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity
J. Clin. Endocrinol. Metab.
92
1451-1457
2007
Homo sapiens
brenda
Araujo, R.L.; de Andrade, B.M.; de Figueiredo, A.S.; da Silva, M.L.; Marassi, M.P.; Pereira, V.d.o.s..S.; Bouskela, E.; Carvalho, D.P.
Low replacement doses of thyroxine during food restriction restores type 1 deiodinase activity in rats and promotes body protein loss
J. Endocrinol.
198
119-125
2008
Rattus norvegicus
brenda
Ng, L.; Hernandez, A.; He, W.; Ren, T.; Srinivas, M.; Ma, M.; Galton, V.A.; St Germain, D.L.; Forrest, D.
A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function
Endocrinology
150
1952-1960
2009
Mus musculus (Q9Z1Y9)
brenda
Boelen, A.; Kwakkel, J.; Wieland, C.W.; St Germain, D.L.; Fliers, E.; Hernandez, A.
Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae
Endocrinology
150
1984-1990
2009
Mus musculus (Q61153), Mus musculus (Q9Z148), Mus musculus
brenda
Aerts, G.; Arrojo E Drigo, R.; Van Herck, S.L.; Sammels, E.; Mirebeau-Prunier, D.; Gereben, B.; Zeoeld, A.; Harney, J.W.; Huang, S.A.; Mulcahey, M.A.; Van der Geyten, S.; Van den Bergh, G.; Arckens, L.; Darras, V.M.; Zavacki, A.M.
Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells
Endocrinology
150
5171-5180
2009
Homo sapiens (P49895), Homo sapiens (Q92813)
brenda
Celi, F.S.; Coppotelli, G.; Chidakel, A.; Kelly, M.; Brillante, B.A.; Shawker, T.; Cherman, N.; Feuillan, P.P.; Collins, M.T.
The role of type 1 and type 2 5-deiodinase in the pathophysiology of the 3,5,3-triiodothyronine toxicosis of McCune-Albright syndrome
J. Clin. Endocrinol. Metab.
93
2383-2389
2008
Homo sapiens
brenda
Ohguchi, H.; Tanaka, T.; Uchida, A.; Magoori, K.; Kudo, H.; Kim, I.; Daigo, K.; Sakakibara, I.; Okamura, M.; Harigae, H.; Sasaki, T.; Osborne, T.F.; Gonzalez, F.J.; Hamakubo, T.; Kodama, T.; Sakai, J.
Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9
Mol. Cell. Biol.
28
3917-3931
2008
Mus musculus (Q61153), Mus musculus
brenda
Zavacki, A.M.; Arrojo E Drigo, R.; Freitas, B.C.; Chung, M.; Harney, J.W.; Egri, P.; Wittmann, G.; Fekete, C.; Gereben, B.; Bianco, A.C.
The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase
Mol. Cell. Biol.
29
5339-5347
2009
Homo sapiens
brenda
Meyer, E.L.; Goemann, I.M.; Dora, J.M.; Wagner, M.S.; Maia, A.L.
Type 2 iodothyronine deiodinase is highly expressed in medullary thyroid carcinoma
Mol. Cell. Endocrinol.
289
16-22
2008
Homo sapiens
brenda
Macek Jilkova, Z.; Pavelka, S.; Flachs, P.; Hensler, M.; Kus, V.; Kopecky, J.
Modulation of type I iodothyronine 5-deiodinase activity in white adipose tissue by nutrition: possible involvement of leptin
Physiol. Res.
59
561-569
2010
Mus musculus
brenda
Lopez-Juarez, A.; Delgado, G.; Aceves, C.; Anguiano, B.
Type 1 deiodinase activity and generation of triiodothyronine (T3) in prostate of sexually active rats
Prostate
69
1651-1659
2009
Rattus norvegicus
brenda
Piekielko-Witkowska, A.; Master, A.; Wojcicka, A.; Boguslawska, J.; Brozda, I.; Tanski, Z.; Nauman, A.
Disturbed expression of type 1 iodothyronine deiodinase splice variants in human renal cancer
Thyroid
19
1105-1113
2009
Homo sapiens (P49895), Homo sapiens
brenda
Goto, K.; Sonoda, D.; Shimada, K.; Sase, S.; Kawashima, T.
Modeling of the 5'-deiodination of thyroxine by iodothyronine deiodinase: Chemical corroboration of a selenenyl iodide intermediate
Angew. Chem.
49
545-547
2010
Homo sapiens
brenda
Manna, D.; Mugesh, G.
A chemical model for the inner-ring deiodination of thyroxine by iodothyronine deiodinase
Angew. Chem.
49
9246-9249
2010
Homo sapiens
-
brenda
Kornasiewicz, O.; Debski, M.; Stepnowska, M.; Sza?as, A.; Bar-Andziak, E.; Krawczyk, M.
The enzymatic activity of type 1 iodothyronine deiodinase (D1) is low in liver hemangioma: a preliminary study
Arch. Immunol. Ther. Exp.
58
77-80
2010
Homo sapiens
brenda
Wang, Y.Y.; Morimoto, S.; Du, C.K.; Lu, Q.W.; Zhan, D.Y.; Tsutsumi, T.; Ide, T.; Miwa, Y.; Takahashi-Yanaga, F.; Sasaguri, T.
Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy
Cardiovasc. Res.
87
636-646
2010
Mus musculus
brenda
Goemann, I.; Gereben, B.; Harney, J.; Zhu, B.; Maia, A.; Larsen, P.
Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells
Endocrinology
151
821-829
2010
Homo sapiens
brenda
Ito, M.; Toyoda, N.; Nomura, E.; Takamura, Y.; Amino, N.; Iwasaka, T.; Takamatsu, J.; Miyauchi, A.; Nishikawa, M.
Type 1 and type 2 iodothyronine deiodinases in the thyroid gland of patients with 3,5,3'-triiodothyronine-predominant Graves' disease
Eur. J. Endocrinol.
164
95-100
2011
Homo sapiens
brenda
Dentice, M.; Marsili, A.; Ambrosio, R.; Guardiola, O.; Sibilio, A.; Paik, J.H.; Minchiotti, G.; DePinho, R.A.; Fenzi, G.; Larsen, P.R.; Salvatore, D.
The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration
J. Clin. Invest.
120
4021-4030
2010
Mus musculus
brenda
Lamirand, A.; Ramauge, M.; Pierre, M.; Courtin, F.
Bacterial lipopolysaccharide induces type 2 deiodinase in cultured rat astrocytes
J. Endocrinol.
208
183-192
2012
Rattus norvegicus
brenda
Pavelka, S.
Radiometric enzyme assays: development of methods for extremely sensitive determination of types 1, 2 and 3 iodothyronine deiodinase enzyme activities
J. Radioanal. Nucl. Chem.
286
861-865
2010
Rattus norvegicus
-
brenda
Bassett, J.H.; Boyde, A.; Howell, P.G.; Bassett, R.H.; Galliford, T.M.; Archanco, M.; Evans, H.; Lawson, M.A.; Croucher, P.; St Germain, D.L.; Galton, V.A.; Williams, G.R.
Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts
Proc. Natl. Acad. Sci. USA
107
7604-7609
2010
Mus musculus
brenda
Piehl, S.; Heberer, T.; Balizs, G.; Scanlan, T.S.; Kohrle, J.
Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates
Rapid Commun. Mass Spectrom.
22
3286-3296
2008
Homo sapiens, Mus musculus
brenda
Ramadan, W.; Marsili, A.; Huang, S.; Larsen, P.R.; Silva, J.E.
Type-2 iodothyronine 5-deiodinase in skeletal muscle of C57BL/6 mice. I. Identity, subcellular localization, and characterization
Endocrinology
152
3082-3092
2011
Mus musculus, Mus musculus C57BL/6
brenda
Barca-Mayo, O.; Liao, X.H.; DiCosmo, C.; Dumitrescu, A.; Moreno-Vinasco, L.; Wade, M.S.; Sammani, S.; Mirzapoiazova, T.; Garcia, J.G.; Refetoff, S.; Weiss, R.E.
Role of type 2 deiodinase in response to acute lung injury (ALI) in mice
Proc. Natl. Acad. Sci. USA
108
E1321-E1329
2011
Mus musculus
brenda
Louzada, R.A.; Santos, M.C.; Cavalcanti-de-Albuquerque, J.P.; Rangel, I.F.; Ferreira, A.C.; Galina, A.; Werneck-de-Castro, J.P.; Carvalho, D.P.
Type 2 iodothyronine deiodinase is upregulated in rat slow- and fast-twitch skeletal muscle during cold exposure
Am. J. Physiol. Endocrinol. Metab.
307
E1020-E1029
2014
Rattus norvegicus (P70551)
brenda
Kornasiewicz, O.; Debski, M.; Grat, M.; Lenartowicz, B.; Stepnowska, M.; Szalas, A.; Bar-Andziak, E.; Krawczyk, M.
Enzymatic activity of type 1 iodothyronine deiodinase in selected liver tumors
Arch. Med. Sci.
10
801-805
2014
Homo sapiens (P49895), Homo sapiens
brenda
Aoki, T.; Tsunekawa, K.; Araki, O.; Ogiwara, T.; Nara, M.; Sumino, H.; Kimura, T.; Murakami, M.
Type 2 iodothyronine deiodinase activity is required for rapid stimulation of PI3K by thyroxine in human umbilical vein endothelial cells
Endocrinology
156
4312-4324
2015
Homo sapiens (Q9C0K2), Homo sapiens
brenda
Wu, T.; Shi, X.; Zhou, Z.; Wang, L.; Wang, M.; Wang, L.; Huang, M.; Yang, C.; Song, L.
An iodothyronine deiodinase from Chlamys farreri and its induced mRNA expression after LPS stimulation
Fish Shellfish Immunol.
33
286-293
2012
Azumapecten farreri (H6U5U5), Azumapecten farreri
brenda
Yamauchi, I.; Sakane, Y.; Yamashita, T.; Hirota, K.; Ueda, Y.; Kanai, Y.; Yamashita, Y.; Kondo, E.; Fujii, T.; Taura, D.; Sone, M.; Yasoda, A.; Inagaki, N.
Effects of growth hormone on thyroid function are mediated by type 2 iodothyronine deiodinase in humans
Endocrine
59
353-363
2018
Homo sapiens
brenda
Awad, H.; Alrefaie, Z.
An evidence for the transcriptional regulation of iodothyronine deiodinase 2 by progesterone in ovarectomized rats
J. Physiol. Biochem.
70
331-339
2014
Rattus norvegicus
brenda
Poplawski, P.; Rybicka, B.; Boguslawska, J.; Rodzik, K.; Visser, T.J.; Nauman, A.; Piekielko-Witkowska, A.
Induction of type 1 iodothyronine deiodinase expression inhibits proliferation and migration of renal cancer cells
Mol. Cell. Endocrinol.
442
58-67
2017
Homo sapiens
brenda
Sakane, Y.; Kanamoto, N.; Yamauchi, I.; Tagami, T.; Morita, Y.; Miura, M.; Sone, M.; Yasoda, A.; Kimura, T.; Nakao, K.; Inagaki, N.
Regulation of type 1 iodothyronine deiodinase by LXRalpha
PLoS ONE
12
e0179213
2017
Homo sapiens
brenda
Poplawski, P.; Wisniewski, J.; Rijntjes, E.; Richards, K.; Rybicka, B.; Kohrle, J.; Piekielko-Witkowska, A.
Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system
PLoS ONE
12
e0190179
2017
Homo sapiens
brenda