Information on EC 1.21.99.4 - thyroxine 5'-deiodinase

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IUBMB Comments
The enzyme activity has only been demonstrated in the direction of 5'-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type II enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
5DI , 5DII , 5DIII , D1 5'-deiodinase, D2 5'-deiodinase, deiodinase, diiodothyronine 5'-deiodinase, Dio, DIO1, DIO2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
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