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Literature summary for 1.21.99.4 extracted from

  • Poplawski, P.; Wisniewski, J.; Rijntjes, E.; Richards, K.; Rybicka, B.; Kohrle, J.; Piekielko-Witkowska, A.
    Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system (2017), PLoS ONE, 12, e0190179 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-thyroxine + reduced acceptor Homo sapiens
-
 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
KIJ-265T cell
-
 Homo sapiens
-
KIJ-308T cell
-
 Homo sapiens
-
renal cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + reduced acceptor
-
 Homo sapiens 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
 ?

Synonyms

Synonyms Comment Organism
DIO1
-
 Homo sapiens
type 1 iodothyronine deiodinase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme loss enhances proliferation and migration of renal cancer cells Homo sapiens