Cloned (Comment) | Organism |
---|---|
overexpression in LLC-PK1 cells | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | integral membrane protein. Once assembled the D1 holoenzyme is sorted to the plasma membrane in both kidney and liver cells, where it can serve as an enzymic barrier to the entry of the prohormone thyroxine and the source of bioactive 3,3',5-triiodothyronine for the cell | Rattus norvegicus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
27000 | - |
2 * 27000 | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | Rattus norvegicus | in kidney and liver cells the enzyme can serve as an enzymic barrier to the entry of the prohormone thyroxine and the source of bioactive 3,3',5-triiodothyronine for the cell | 3,3',5-triiodothyronine + iodide + A + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P24389 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | in kidney and liver cells the enzyme can serve as an enzymic barrier to the entry of the prohormone thyroxine and the source of bioactive 3,3',5-triiodothyronine for the cell | Rattus norvegicus | 3,3',5-triiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + electron acceptor | - |
Rattus norvegicus | 3,3',5-triiodothyronine + iodide + reduced electron acceptor | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 27000 | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
type I iodothyronine deiodinase | - |
Rattus norvegicus |