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Literature summary for 1.21.99.4 extracted from

  • Louzada, R.A.; Santos, M.C.; Cavalcanti-de-Albuquerque, J.P.; Rangel, I.F.; Ferreira, A.C.; Galina, A.; Werneck-de-Castro, J.P.; Carvalho, D.P.
    Type 2 iodothyronine deiodinase is upregulated in rat slow- and fast-twitch skeletal muscle during cold exposure (2014), Am. J. Physiol. Endocrinol. Metab., 307, E1020-E1029.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information in red oxidative soleus muscle, isoform Dio2 activity increases 2.3fold after 3 days at 4°C together with the brown adipose tissue Dio2 activity, which increases 10fold. Soleus muscle and the brown adipose tissue Dio2 activities return to the control levels after 10 days of cold exposure, when an increase of 2.8fold in Dio2 activity is detected in white glycolytic gastrocnemius but not in red oxidative gastrocnemius fibers. Propranolol does not prevent muscle Dio2 induction, but it impairs the decrease of Dio2 in the brown adipose tissue and soleus after 10 days at 4°C. Serum total and free T3 is increased during cold exposure in rats Rattus norvegicus
propranolol propanolol does not prevent muscle Dio2 induction, but impairs a decrease of Dio2 in the brown adipose tissue and soleus after 10 days at 4°C Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P70551
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-

Source Tissue

Source Tissue Comment Organism Textmining
gastrocnemius after 10 days of cold exposure an increase of 2.8fold in Dio2 activity is detected in white glycolytic gastrocnemius but not in red oxidative gastrocnemius fibers Rattus norvegicus
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muscle in red oxidative soleus muscle, isoform Dio2 activity increases 2.3fold after 3 days at 4°C together with the brown adipose tissue Dio2 activity, which increases 10fold. Soleus muscle and the brown adipose tissue Dio2 activities return to the control levels after 10 days of cold exposure Rattus norvegicus
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Synonyms

Synonyms Comment Organism
DIO2
-
Rattus norvegicus
type II iodothyronine deiodinase
-
Rattus norvegicus

General Information

General Information Comment Organism
physiological function in red oxidative soleus muscle, isoform Dio2 activity increases 2.3fold after 3 days at 4°C together with the brown adipose tissue Dio2 activity, which increases 10fold. Soleus muscle and the brown adipose tissue Dio2 activities return to the control levels after 10 days of cold exposure, when an increase of 2.8fold in Dio2 activity is detected in white glycolytic gastrocnemius but not in red oxidative gastrocnemius fibers. Propranolol does not prevent muscle Dio2 induction, but it impairs the decrease of Dio2 in the brown adipose tissue and soleus after 10 days at 4°C. Serum total and free T3 is increased during cold exposure in rats Rattus norvegicus