Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | in red oxidative soleus muscle, isoform Dio2 activity increases 2.3fold after 3 days at 4°C together with the brown adipose tissue Dio2 activity, which increases 10fold. Soleus muscle and the brown adipose tissue Dio2 activities return to the control levels after 10 days of cold exposure, when an increase of 2.8fold in Dio2 activity is detected in white glycolytic gastrocnemius but not in red oxidative gastrocnemius fibers. Propranolol does not prevent muscle Dio2 induction, but it impairs the decrease of Dio2 in the brown adipose tissue and soleus after 10 days at 4°C. Serum total and free T3 is increased during cold exposure in rats | Rattus norvegicus | |
propranolol | propanolol does not prevent muscle Dio2 induction, but impairs a decrease of Dio2 in the brown adipose tissue and soleus after 10 days at 4°C | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P70551 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastrocnemius | after 10 days of cold exposure an increase of 2.8fold in Dio2 activity is detected in white glycolytic gastrocnemius but not in red oxidative gastrocnemius fibers | Rattus norvegicus | - |
muscle | in red oxidative soleus muscle, isoform Dio2 activity increases 2.3fold after 3 days at 4°C together with the brown adipose tissue Dio2 activity, which increases 10fold. Soleus muscle and the brown adipose tissue Dio2 activities return to the control levels after 10 days of cold exposure | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
DIO2 | - |
Rattus norvegicus |
type II iodothyronine deiodinase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | in red oxidative soleus muscle, isoform Dio2 activity increases 2.3fold after 3 days at 4°C together with the brown adipose tissue Dio2 activity, which increases 10fold. Soleus muscle and the brown adipose tissue Dio2 activities return to the control levels after 10 days of cold exposure, when an increase of 2.8fold in Dio2 activity is detected in white glycolytic gastrocnemius but not in red oxidative gastrocnemius fibers. Propranolol does not prevent muscle Dio2 induction, but it impairs the decrease of Dio2 in the brown adipose tissue and soleus after 10 days at 4°C. Serum total and free T3 is increased during cold exposure in rats | Rattus norvegicus |