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Literature summary for 1.21.99.4 extracted from

  • Bassett, J.H.; Boyde, A.; Howell, P.G.; Bassett, R.H.; Galliford, T.M.; Archanco, M.; Evans, H.; Lawson, M.A.; Croucher, P.; St Germain, D.L.; Galton, V.A.; Williams, G.R.
    Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts (2010), Proc. Natl. Acad. Sci. USA, 107, 7604-7609.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-thyroxine + AH2 Mus musculus
-
 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
osteoblast the enzyme is restricted to mature primary osteoblasts Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + AH2
-
 Mus musculus 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Synonyms

Synonyms Comment Organism
type 2 iodothyronine deiodinase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
dithiothreitol
-
 Mus musculus

General Information

General Information Comment Organism
malfunction bones from adult type 2 iodothyronine deiodinase-knockout mice have reduced toughness and are brittle, displaying an increased susceptibility to fracture. This phenotype is characterized by a 50% reduction in bone formation and a generalized increase in skeletal mineralization Mus musculus
physiological function type 2 iodothyronine deiodinase plays a role in the optimization of bone strength and mineralization and is essential for normal osteoblast function Mus musculus