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Literature summary for 1.21.99.4 extracted from

  • Dentice, M.; Marsili, A.; Ambrosio, R.; Guardiola, O.; Sibilio, A.; Paik, J.H.; Minchiotti, G.; DePinho, R.A.; Fenzi, G.; Larsen, P.R.; Salvatore, D.
    The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration (2010), J. Clin. Invest., 120, 4021-4030.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.21.99.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,3',5'-triiodothyronine + AH2 Mus musculus
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 Mus musculus
-
 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
-
 Mus musculus
-
muscle
-
 Mus musculus
-
muscle progenitor cell high expression Mus musculus
-
myoblast
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triiodothyronine + AH2
-
 Mus musculus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2
-
 Mus musculus 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Synonyms

Synonyms Comment Organism
DIO2
-
 Mus musculus
type 2 deiodinase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
dithiothreitol
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus type 2 deiodinase is induced in muscle regeneration, forkhead box O3 is a key molecule inducing type 2 deiodinase expression up

General Information

General Information Comment Organism
malfunction after injury regeneration markedly delays in muscles of mice null for the gene encoding type 2 deiodinase, despite normal circulating 3,5,3'-triiodo-L-thyronine concentrations, Dio2-deficient mice show muscle-specific hypothyroidism Mus musculus
physiological function type 2 deiodinase is essential for normal mouse myogenesis and muscle regeneration Mus musculus