Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-3-[4-[(4-hydroxy-3,5-diiodophenyl)thio]-3,5-diiodophenyl]propanoic acid | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
3',5'-diiodothyronine | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
3,3',5'-triiodothyronine | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
3,5,3'-triiodo-5'-nitrothyronine | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
3,5,5'-triiodo-2'-methylthyronine | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
3,5-diiodo-2'-hydroxythyronine | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
3,5-diiodo-3',5'-dinitrothyronine | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
3,5-diiodo-3'-hydroxythyronine | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
3,5-diiodo-4'-amino-3',5'-dimethylthyronine | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
ethyl 4-(4-hydroxy-3,5-diiodobenzoyl)phenyl carbonate | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
N-acetyl-3,5,3'-triiodo-5'-nitrothyronine | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
N-acetyl-3,5-diiodo-3',5'-dinitrothyronine | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
N-acetyl-3,5-diiodo-3'-bromo-5'-nitrothyronine | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
Tetraiodothyroacetic acid | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
[4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
[4-(4-hydroxy-3,5-dinitrophenoxy)-3,5-diiodophenyl]acetic acid | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)-3,5-diiodophenyl]acetic acid | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus | |
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)phenyl]acetic acid | comparison with 5-deiodinase EC 1.97.1.11 | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
L-thyroxine | pH 7.4, 37°C | Rattus norvegicus | |
0.01 | - |
3,5'-diiodo-L-thyronine | pH 7.4, 37°C | Rattus norvegicus | |
0.02 | - |
3,3',5'-triiodo-L-thyronine | pH 7.4, 37°C | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodo-L-thyronine + AH2 | Rattus norvegicus | - |
3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
3,5'-diiodo-L-thyronine + AH2 | Rattus norvegicus | - |
3-iodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | Rattus norvegicus | - |
3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
additional information | Rattus norvegicus | L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodo-L-thyronine + AH2 | - |
Rattus norvegicus | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
3,5'-diiodo-L-thyronine + AH2 | - |
Rattus norvegicus | 3-iodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | - |
Rattus norvegicus | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
additional information | L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway | Rattus norvegicus | ? | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0002 | - |
pH 7.4, 37°C | Rattus norvegicus | Tetraiodothyroacetic acid | |
0.0003 | - |
pH 7.4, 37°C | Rattus norvegicus | 3,3',5'-triiodothyronine | |
0.0003 | - |
pH 7.4, 37°C | Rattus norvegicus | [4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid | |
0.0005 | - |
pH 7.4, 37°C | Rattus norvegicus | [4-(4-hydroxy-3-iodo-5-nitrophenoxy)-3,5-diiodophenyl]acetate | |
0.0008 | - |
pH 7.4, 37°C | Rattus norvegicus | [4-(4-hydroxy-3-iodo-5-nitrophenoxy)phenyl]acetic acid | |
0.001 | - |
pH 7.4, 37°C | Rattus norvegicus | 3',5'-diiodothyronine | |
0.0015 | - |
pH 7.4, 37°C | Rattus norvegicus | N-acetyl-3,5,3'-triiodo-5'-nitrothyronine | |
0.0015 | - |
pH 7.4, 37°C | Rattus norvegicus | [4-(4-hydroxy-3,5-dinitrophenoxy)-3,5-diiodophenyl]acetic acid | |
0.002 | - |
pH 7.4, 37°C | Rattus norvegicus | ethyl 4-(4-hydroxy-3,5-diiodobenzoyl)phenyl carbonate | |
0.003 | - |
- |
Rattus norvegicus | 2-amino-3-[4-[(4-hydroxy-3,5-diiodophenyl)thio]-3,5-diiodophenyl]propanoate | |
0.004 | - |
pH 7.4, 37°C | Rattus norvegicus | N-acetyl-3,5-diiodo-3'-bromo-5'-nitrothyronine | |
0.007 | - |
pH 7.4, 37°C | Rattus norvegicus | 3,5,5'-triiodo-2'-methylthyronine | |
0.007 | - |
pH 7.4, 37°C | Rattus norvegicus | N-acetyl-3,5-diiodo-3',5'-dinitrothyronine | |
0.008 | - |
pH 7.4, 37°C | Rattus norvegicus | 3,5,3'-triiodo-5'-nitrothyronine | |
0.008 | - |
pH 7.4, 37°C | Rattus norvegicus | 3,5-diiodo-2'-hydroxythyronine | |
0.012 | - |
pH 7.4, 37°C | Rattus norvegicus | 3,5-diiodo-4'-amino-3',5'-dimethylthyronine | |
0.013 | - |
pH 7.4, 37°C | Rattus norvegicus | 3,5-diiodo-3'-hydroxythyronine | |
0.014 | - |
pH 7.4, 37°C | Rattus norvegicus | 3,5-diiodo-3',5'-dinitrothyronine |