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Literature summary for 1.21.99.4 extracted from

  • Ng, L.; Hernandez, A.; He, W.; Ren, T.; Srinivas, M.; Ma, M.; Galton, V.A.; St Germain, D.L.; Forrest, D.
    A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function (2009), Endocrinology, 150, 1952-1960.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.21.99.4

Organism

Organism UniProt Comment Textmining
Mus musculus Q9Z1Y9 wild-type and type 3 deiodinase knockdown mice
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Source Tissue

Source Tissue Comment Organism Textmining
cochlea
-
 Mus musculus
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pup
-
 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5,5'-tetraiodo-L-thyronine + AH2
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 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
type 2 deiodinase
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 Mus musculus

Cofactor

Cofactor Comment Organism Structure
dithiothreitol 20 mM Mus musculus

Expression

Organism Comment Expression
Mus musculus increase of expression levels postnatal until day 8 up

General Information

General Information Comment Organism
physiological function increase of thyroid hormone in cochlea by type 2 deiodinase, resulting in impairment of 3,3',5-triiodo-L-thyronine, before the onset of hearing Mus musculus