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Literature summary for 1.21.99.4 extracted from

  • Kanou, Y.; Hishinuma, A.; Tsunekawa, K.; Seki, K.; Mizuno, Y.; Fujisawa, H.; Imai, T.; Miura, Y.; Nagasaka, T.; Yamada, C.; Ieiri, T.; Murakami, M.; Murata, Y.
    Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity (2007), J. Clin. Endocrinol. Metab., 92, 1451-1457.
    View publication on PubMed

Application

Application Comment Organism
medicine thyroglobulin gene mutations induce defective intracellular transport of thyroglobulin leading to increased thyroidal type 2 iodothyronine deiodinase activity, increased thyroidal type 2 deiodinase activity accounts for a relatively high serum free T3 level with a disproportionately low serum free T4 level Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
patients with thyroglobulin transport defect
-

Source Tissue

Source Tissue Comment Organism Textmining
thyroid gland after surgery Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000001
-
healthy control Homo sapiens
0.0000025
-
patient with mutation in thyroglobulin gene Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + AH2 addition of I125 labelled T4 to measure the production of T3 Homo sapiens 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
?

Synonyms

Synonyms Comment Organism
type 2 deiodinase
-
Homo sapiens