Application | Comment | Organism |
---|---|---|
medicine | thyroglobulin gene mutations induce defective intracellular transport of thyroglobulin leading to increased thyroidal type 2 iodothyronine deiodinase activity, increased thyroidal type 2 deiodinase activity accounts for a relatively high serum free T3 level with a disproportionately low serum free T4 level | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
patients with thyroglobulin transport defect | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thyroid gland | after surgery | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000001 | - |
healthy control | Homo sapiens |
0.0000025 | - |
patient with mutation in thyroglobulin gene | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | addition of I125 labelled T4 to measure the production of T3 | Homo sapiens | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type 2 deiodinase | - |
Homo sapiens |