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Literature summary for 1.21.99.4 extracted from

  • Visser, T.J.
    Deiodination of thyroid hormone and the role of glutathione (1980), Trends Biochem. Sci., 5, 222-224.
No PubMed abstract available
Search for more literature for 1.21.99.4

Activating Compound

Activating Compound Comment Organism Structure
EDTA
-
 Rattus sp.
reduced thiols e.g. dithiothreitol Rattus sp.
reduced thiols e.g. ethanethiol, glutathione Rattus sp.

Inhibitors

Inhibitors Comment Organism Structure
2-Thiouracil
-
 Rattus sp.
6-Propyl-2-thiouracil inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity Rattus sp.
additional information 3,3',5'-triiodothyronine blocks 5'-deiodination of L-thyroxine blocks 5'-deiodination of 3,3',5'-triiodothyronine Rattus sp.
SH-group blocking reagents
-
 Rattus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,3',5'-triiodothyronine + AH2 Rattus sp. isoenzyme type I 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5-triiodothyronine + AH2 Rattus sp. isoenzyme type II and type III 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5-triiodothyronine + AH2 Rattus sp.
-
 3,5-diiodothyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 Rattus sp. thyronine 5'-deiodinase type II 3,3',5-triiodothyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 Rattus sp. idothyronine 5'-deiodinase type I 3,3',5'-triiodothyronine + iodide + A + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
 overview
-

Reaction

Reaction Comment Organism Reaction ID
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor reaction mechanism of thyronine 5'-deiodinase Rattus sp.
a
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor type III, inner (tyrosyl) ring deiodination Rattus sp.
a
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor type II, outer ring (phenolic) deiodination Rattus sp.
a
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor type I, outer ring (phenolic) deiodination Rattus sp.
a

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus sp.
-
liver
-
 Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triiodothyronine + AH2 isoenzyme type I Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5-triiodothyronine + AH2
-
 Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5-triiodothyronine + AH2 isoenzyme type II and type III Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5-triiodothyronine + AH2
-
 Rattus sp. 3,5-diiodothyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 thyronine 5'-deiodinase type II Rattus sp. 3,3',5-triiodothyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 thyronine 5-deiodinase type Rattus sp. 3,3',5'-triiodothyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 idothyronine 5'-deiodinase type I Rattus sp. 3,3',5'-triiodothyronine + iodide + A + H+
-
 ?

Synonyms

Synonyms Comment Organism
iodothyronine 5'-deiodinase iodothyronine 5'-deiodinase type Rattus sp.
iodothyronine 5-deiodinase iodothyronine 5-deiodinase type Rattus sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Rattus sp.

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8
-
 Rattus sp.