Information on EC 4.1.1.15 - Glutamate decarboxylase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
4.1.1.15
-
RECOMMENDED NAME
GeneOntology No.
Glutamate decarboxylase
PATHWAY
KEGG Link
MetaCyc Link
Alanine, aspartate and glutamate metabolism
-
beta-Alanine metabolism
-
Biosynthesis of secondary metabolites
-
Butanoate metabolism
-
GABA shunt
-
glutamate degradation IV
-
glutamate degradation IX (via 4-aminobutyrate)
-
glutamate dependent acid resistance
-
Metabolic pathways
-
Taurine and hypotaurine metabolism
-
SYSTEMATIC NAME
IUBMB Comments
L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
A pyridoxal-phosphate protein. The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
42 kDa biotin-coupled protein
-
exhibits both glutamine synthetase activity and glutamate decarboxylase activity
65 kDa glutamic acid decarboxylase
-
-
-
-
67 kDa glutamic acid decarboxylase
-
-
-
-
Aspartate 1-decarboxylase
-
-
-
-
Aspartic alpha-decarboxylase
-
-
-
-
Cysteic acid decarboxylase
-
-
-
-
Decarboxylase, glutamate
-
-
-
-
ERT D1
-
-
-
-
GAD
-
-
-
-
GAD
Dugesia japonica SSP
-
-
-
GAD
Q05329, Q99259
-
GAD
Lactobacillus brevis CGMCC
-
-
-
GAD
Lactobacillus brevis IFO12005
A9ZM78
-
-
GAD
Lactobacillus brevis Lb85
-
-
-
GAD
Lactobacillus paracasei NFRI 7415
B1B389
-
-
GAD
Lactobacillus plantarum ATCC 14917
-
-
-
GAD
B2ZX20
-
GAD
Mus musculus B6D2, Mus musculus BALB/c
-
-
-
GAD
Q9AR41
-
GAD
A0EJ89
-
GAD-65
-
-
-
-
GAD-67
-
-
-
-
GAD-alpha
-
-
-
-
GAD-beta
-
-
-
-
GAD-gamma
-
-
-
-
GAD1
Q7XJB3
-
GAD1
-
-
GAD1
-
-
GAD2
-
-
GAD3
-
-
GAD65
-
; isoform
GAD65
Q05329
-
GAD65
-
65 kDa isoform of glutamic acid decarboxylase
GAD65
-
65-kDa isoform of GAD
GAD65
-
65-kilodalton isoform of glutamate decarboxylase
GAD65
Rattus norvegicus LEW-1A
-
-
-
GAD65
-
-
GAD67
Q99259
-
GAD67
-
67 kDa form of the glutamic acid decarboxylase
GADCase
-
-
-
-
gamma-Glutamate decarboxylase
-
-
-
-
GDCase
-
-
-
-
glutamate decarboxylase
-
-
glutamate decarboxylase 1
-
-
glutamate decarboxylase 65
-
-
glutamate decarboxylase 67
-
-
Glutamic acid decarboxylase
-
-
-
-
Glutamic acid decarboxylase
-, Q4PRC2
-
Glutamic acid decarboxylase
-
-
Glutamic acid decarboxylase
Dugesia japonica SSP
-
-
-
Glutamic acid decarboxylase
-
-
Glutamic acid decarboxylase
Q7XJB3
-
Glutamic acid decarboxylase
Q05329, Q99259
-
Glutamic acid decarboxylase
-
-
Glutamic acid decarboxylase
B2ZX20
-
Glutamic acid decarboxylase
Mus musculus BALB/c
-
-
-
Glutamic acid decarboxylase
-
-
Glutamic acid decarboxylase
Rattus norvegicus LEW-1A
-
-
-
Glutamic acid decarboxylase
-
-
glutamic acid decarboxylase 65
-
; isoform
glutamic acid decarboxylase 65
-
65 kDa isoform of glutamic acid decarboxylase
glutamic acid decarboxylase 65
-
-
glutamic acid decarboxylase 67
-
-
glutamic acid decarboxylase 67
-
-
glutamic acid decarboxylase 67
-
-
glutamic acid decarboxylase 67
-
-
glutamic acid decarboxylase 67
-
67 kDa form of the glutamic acid decarboxylase
glutamic acid decarboxylase-65
-
-
glutamic acid decarboxylase-67
-
-
glutamic acid decarboxylase67
Q99259
-
Glutamic decarboxylase
-
-
-
-
L-Aspartate-alpha-decarboxylase
-
-
-
-
L-Glutamate alpha-decarboxylase
-
-
-
-
L-Glutamate decarboxylase
-
-
-
-
L-Glutamate decarboxylase
-
-
L-Glutamic acid decarboxylase
-
-
-
-
L-Glutamic acid decarboxylase
-
-
L-Glutamic acid decarboxylase
Q05329, Q99259
-
L-Glutamic acid decarboxylase
-
-
L-Glutamic decarboxylase
-
-
-
-
MGAD
-
-
-
-
p42
-
exhibits both glutamine synthetase activity and glutamate decarboxylase activity
MGAD
-
membrane-associated form of L-glutamate decarboxylase
additional information
-
GAD belongs to a subset of pyridoxal 5'-phosphate-dependent enzymes classified as group 2
CAS REGISTRY NUMBER
COMMENTARY
9024-58-2
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
strain L. Heynh. Ecotype Columbia, 2 isoenzymes: GAD1 and GAD2
-
-
Manually annotated by BRENDA team
GAD2; gene GAD2
UniProt
Manually annotated by BRENDA team
isoform GAD65, comparison with human isoform GAD65
-
-
Manually annotated by BRENDA team
strain SSP
-
-
Manually annotated by BRENDA team
Dugesia japonica SSP
strain SSP
-
-
Manually annotated by BRENDA team
isozyme GADalpha
-
-
Manually annotated by BRENDA team
alcohol dependent and non-alcohol dependent individuals of Irish origin, male and female
-
-
Manually annotated by BRENDA team
coexpression with murine IL-4 in tobacco
-
-
Manually annotated by BRENDA team
GAD65
UniProt
Manually annotated by BRENDA team
GAD67
UniProt
Manually annotated by BRENDA team
gene GAD1 encodes the isozyme GAD67
-
-
Manually annotated by BRENDA team
gene GAD65
-
-
Manually annotated by BRENDA team
isoform GAD65
-
-
Manually annotated by BRENDA team
isoform GAD65 and GAD67
-
-
Manually annotated by BRENDA team
isoform GAD65, comparison with goldfish isoform GAD65
-
-
Manually annotated by BRENDA team
isoform GAD67, patients diagnosed with major unipolar depression
-
-
Manually annotated by BRENDA team
isozymes GAD65 and GAD67
-
-
Manually annotated by BRENDA team
patients with diabetes and thyroid autoimmune diseases
-
-
Manually annotated by BRENDA team
recombinant isoform GAD67
-
-
Manually annotated by BRENDA team
recombinant isoforms GAD65 and GAD67
-
-
Manually annotated by BRENDA team
smaller isoform of glutamate decarboxylase, GAD65
-
-
Manually annotated by BRENDA team
two isozymes Gad65 and GAd67, male and female Graves' disease patients
-
-
Manually annotated by BRENDA team
type 1 diabetes mellitus patients
-
-
Manually annotated by BRENDA team
IFO 12005
-
-
Manually annotated by BRENDA team
strain IFO12005, gene gadB
A9ZM78
UniProt
Manually annotated by BRENDA team
Lactobacillus brevis CGMCC
-
-
-
Manually annotated by BRENDA team
Lactobacillus brevis IFO12005
strain IFO12005, gene gadB
A9ZM78
UniProt
Manually annotated by BRENDA team
Lactobacillus brevis Lb85
-
-
-
Manually annotated by BRENDA team
gene gadB; strain NFRI 7415, gene gadB
UniProt
Manually annotated by BRENDA team
Lactobacillus paracasei NFRI 7415
gene gadB; strain NFRI 7415, gene gadB
UniProt
Manually annotated by BRENDA team
Lactobacillus plantarum ATCC 14917
-
-
-
Manually annotated by BRENDA team
serovars 1/2a and 4b
-
-
Manually annotated by BRENDA team
strain LO28, having a GAD system consisting of enzyme plus a glutamate/gamma-aminobutyrate antiporter. Enzyme/transporter pair GAD2/T2 is primarily responsible for surviving severe acid challenge, enzyme GAD1 plays a major role in growth at mildly acidic pH-values
-
-
Manually annotated by BRENDA team
strain LO28, having a GAD system consisting of enzyme plus a glutamate/gamma-aminobutyrate antiporter. Enzyme/transporter pair GAD2/T2 is primarily responsible for surviving severe acid challenge, enzyme GAD1 plays a major role in growth at mildly acidic pH-values
-
-
Manually annotated by BRENDA team
male monkeys
-
-
Manually annotated by BRENDA team
isoform GAD65
-
-
Manually annotated by BRENDA team
Balb/c mice
-
-
Manually annotated by BRENDA team
C57BL/6 mice
-
-
Manually annotated by BRENDA team
gene GAD67
-
-
Manually annotated by BRENDA team
male C57BI/6 mice, genes GAD65 and GAD67 encoding the 65-kDa and the 67-kDa isozymes of glutamic acid decarboxylase
-
-
Manually annotated by BRENDA team
male FVB/NJ mice
SwissProt
Manually annotated by BRENDA team
strain B6D2
-
-
Manually annotated by BRENDA team
Mus musculus B6D2
strain B6D2
-
-
Manually annotated by BRENDA team
Mus musculus BALB/c
Balb/c mice
-
-
Manually annotated by BRENDA team
spleen from Dasypus novemcinctus infected with Mycobacterium leprae
-
-
Manually annotated by BRENDA team
no activity in Lactococcus lactis subsp. cremoris
-
-
-
Manually annotated by BRENDA team
-
Swissprot
Manually annotated by BRENDA team
cultivar Shangshi Jing 315
-
-
Manually annotated by BRENDA team
expression in Bifidobacterium longum
-
-
Manually annotated by BRENDA team
isoform GAD2
UniProt
Manually annotated by BRENDA team
gene PH0937
-
-
Manually annotated by BRENDA team
isoforms GAD65 and GAD67
-
-
Manually annotated by BRENDA team
isoforms GAD65 and GAD67, expression in Sf9/baculovirus system
-
-
Manually annotated by BRENDA team
isozymes GAD67 and GAD65, encoded by different genes
-
-
Manually annotated by BRENDA team
male sprague-dawley rats
-
-
Manually annotated by BRENDA team
male Wistar rats
-
-
Manually annotated by BRENDA team
strain LEW-1A and BB/OK
-
-
Manually annotated by BRENDA team
Rattus norvegicus LEW-1A
strain LEW-1A and BB/OK
-
-
Manually annotated by BRENDA team
serotypes Typhimurium and Enteritidis
-
-
Manually annotated by BRENDA team
ssp. thermophilus Y2, gene gadB
UniProt
Manually annotated by BRENDA team
inbred line DH4866
-
-
Manually annotated by BRENDA team
kcat/KM VALUE [1/mMs-1]
kcat/KM VALUE [1/mMs-1] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
10.08
-
L-glutamate
P69910
mutant enzyme DELTAHT, in 0.2 M pyridine/HCl buffer, pH 4.6, at 37°C
12211
10.71
-
L-glutamate
P69910
wild type enzyme, in 0.2 M pyridine/HCl buffer, pH 4.6, at 37°C
12211
13.74
-
L-glutamate
P69910
mutant enzyme H465A, in 0.2 M pyridine/HCl buffer, pH 4.6, at 37°C
12211