Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamate | Homo sapiens | GAD is the key enzyme of GABA synthesis, alterations of GABAergic neurotransmission are assumed to play a crucial role in the pathophysiology of mood disorders, overview. Increased relative density of GAD-immunoreactive neuropil, suggests the diathesis of GABAergic system specific for depressed suicidal patients | 4-aminobutanoate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes GAD65 and GAD67 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
entorhinal cortex | - |
Homo sapiens | - |
hippocampus | - |
Homo sapiens | - |
laterodorsal thalamic nucleus | - |
Homo sapiens | - |
medial dorsal nucleus of thalamus | - |
Homo sapiens | - |
additional information | quantitative immunohistochemic analysis GAD-immunoreactive neuropils of GAD65 and GAD67 isozymes in brains of depressed and healthy individuals, overview | Homo sapiens | - |
prefrontal cortex | orbitofrontal, anterior cingulate, and dorsolateral | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamate | - |
Homo sapiens | 4-aminobutanoate + CO2 | - |
? | |
L-glutamate | GAD is the key enzyme of GABA synthesis, alterations of GABAergic neurotransmission are assumed to play a crucial role in the pathophysiology of mood disorders, overview. Increased relative density of GAD-immunoreactive neuropil, suggests the diathesis of GABAergic system specific for depressed suicidal patients | Homo sapiens | 4-aminobutanoate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GAD | - |
Homo sapiens |
Glutamic acid decarboxylase | - |
Homo sapiens |